A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

Nature Genetics

Volumn 38, Issue 6, 2006, Pages 617-619

  Smyth, Deborah J ^a   Cooper, Jason D ^a   Bailey, Rebecca ^a   Field, Sarah ^a   Burren, Oliver ^a   Smink, Luc J ^a   Guja, Cristian ^b   Ionescu Tirgoviste, Constantin ^b   Widmer, Barry ^c   Dunger, David B ^c   Savage, David A ^d   Walker, Neil M ^a   Clayton, David G ^a   Todd, John A ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b Nutrition and Metabolic Diseases 'N Paulescu'   (Romania)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GENE PRODUCT; GRANCALCIN; HELICASE; HLA ANTIGEN CLASS 2; INSULIN; INTERFERON; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; PROTEIN TYROSINE PHOSPHATASE; SEPRASE; UNCLASSIFIED DRUG; VIRUS RNA; VOLTAGE GATED POTASSIUM CHANNEL;

APOPTOSIS; ARTICLE; CASE CONTROL STUDY; CHROMOSOME 10P; CHROMOSOME 2Q; CONTROLLED STUDY; CPG ISLAND; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; IFIH1 GENE; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; NORWAY; PRIORITY JOURNAL; ROMANIA; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS; UNITED KINGDOM; VIRUS INFECTION;

EID: 33745240931     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1800     Document Type: Article

References (15)

1. Cucca, F. et al. Hum. Mol. Genet. 10, 2025-2037 (2001).
2. Bell, G.I., Horita, S. & Karam, J.H. Diabetes 33, 176-183 (1984).
3. Barratt, B.J. et al. Diabetes 53, 1884-1889 (2004).
4. Nistico, L. et al. Hum. Mol. Genet. 5, 1075-1080 (1996).
5. Ueda, H. et al. Nature 423, 506-511 (2003).
6. Bottini, N. et al. Nat. Genet. 36, 337-338 (2004).
7. Smyth, D. et al. Diabetes 53, 3020-3023 (2004).
8. Vella, A. et al. Am. J. Hum. Genet. 76, 773-779 (2005).
9. Hardenbol, P. et al. Genome Res. 15, 269-275 (2005).
10. Clayton, D.G. et al. Nat. Genet. 37, 1243-1246 (2005).
11. Wang, W.Y., Barratt, B.J., Clayton, D.G. & Todd, J.A. Nat. Rev. Genet. 6, 109-118 (2005).
12. Power, C. & Elliott, J. Int. J. Epidemiol. 35, 34-41 (2006).
13. Andrejeva, J. et al. Proc. Natl. Acad. Sci. USA 101, 17264-17269 (2004).
14. Knip, M. et al. Diabetes 54, S125-S136 (2005).
15. Weinberg, C.R., Wilcox, A.J. & Lie, R.T. Am. J. Hum. Genet. 62, 969-978 (1998).