Opposing effects of HLA class I molecules in tuning autoreactive CD8 + T cells in multiple sclerosis

Nature Medicine

Volumn 14, Issue 11, 2008, Pages 1227-1235

  Friese, Manuel A ^a,b   Jakobsen, Karen B ^a   Friis, Lone ^a   Etzensperger, Ruth ^a   Craner, Matthew J ^a   McMahon, Róisín M ^a   Jensen, Lise T ^c   Huygelen, Véronique ^a   Jones, E Yvonne ^a   Bell, John I ^a   Fugger, Lars ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CLONE; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; HUMAN; HUMAN CELL; LYMPHOCYTIC INFILTRATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MICE; MICE, TRANSGENIC; MULTIPLE SCLEROSIS; RECEPTORS, ANTIGEN, T-CELL; THYMUS GLAND;

MUS;

EID: 55549104692     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.1881     Document Type: Article

References (50)

1. Sospedra, M. & Martin, R. Immunology of multiple sclerosis. Annu. Rev. Immunol. 23, 683-747 (2005).
2. Hafler, D.A. et al. Risk alleles for multiple sclerosis identified by a genomewide study. N. Engl. J. Med. 357, 851-862 (2007).
3. Olerup, O. & Hillert, J. HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation. Tissue Antigens 38, 1-15 (1991).
4. van Oosten, B.W. et al. Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: results of a randomized, double-blind, placebo-controlled, MR-monitored phase II trial. Neurology 49, 351-357 (1997).
5. Segal, B.M. et al. Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study. Lancet Neurol. 7, 796-804 (2008).
6. Coles, A.J. et al. Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis. Ann. Neurol. 46, 296-304 (1999).
7. Polman, C.H. et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 354, 899-910 (2006).
8. H1 model for multiple sclerosis: a critical [correction of crucial] re-appraisal. Trends Immunol. 25, 132-137 (2004).
9. + T cells in multiple sclerosis and its animal models. Curr. Drug Targets Inflamm. Allergy 4, 239-245 (2005).
10. + T cells in multiple sclerosis: a new target for therapy? Brain 128, 1747-1763 (2005).
11. Hauser, S.L. et al. Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann. Neurol. 19, 578-587 (1986).
12. Booss, J., Esiri, M.M., Tourtellotte, W.W. & Mason, D.Y. Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. J. Neurol. Sci. 62, 219-232 (1983).
13. + T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J. Exp. Med. 192, 393-404 (2000).
14. Junker, A. et al. Multiple sclerosis: T cell receptor expression in distinct brain regions. Brain 130, 2789-2799 (2007).
15. + T cells in a model for multiple sclerosis. J. Exp. Med. 194, 669-676 (2001).
16. + T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J. Immunol. 166, 7579-7587 (2001).
17. -/- mice. Science 256, 1210-1213 (1992).
18. + T cells in murine experimental allergic encephalomyelitis. Science 256, 1213-1215 (1992).
19. - T cells in an autoimmune disease model. J. Clin. Invest. 112, 1037-1048 (2003).
20. Sawcer, S. et al. A high-density screen for linkage in multiple sclerosis. Am. J. Hum. Genet. 77, 454-467 (2005).
21. Haines, J.L. et al. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group. Hum. Mol. Genet. 7, 1229-1234 (1998).
22. Jersild, C. et al. Histocompatibility determinants in multiple sclerosis, with special reference to clinical course. Lancet 2, 1221-1225 (1973).
23. Marrosu, M.G. et al. Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia. Hum. Mol. Genet. 10, 2907-2916 (2001).
24. Rubio, J.P. et al. Genetic dissection of the human leukocyte antigen region by use of haplotypes of Tasmanians with multiple sclerosis. Am. J. Hum. Genet. 70, 1125-1137 (2002).
25. Burfoot, R.K. et al. SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. Tissue Antigens 71, 42-50 (2008).
26. Fogdell-Hahn, A., Ligers, A., Gronning, M., Hillert, J. & Olerup, O. Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease. Tissue Antigens 55, 140-148 (2000).
27. Harbo, H.F. et al. Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis. Tissue Antigens 63, 237-247 (2004).
28. Brynedal, B. et al. HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis. PLoS ONE 2, e664 (2007).
29. Lincoln, M.R. et al. A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. Nat. Genet. 37, 1108-1112 (2005).
30. Chao, M.J. et al. Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium. Hum. Mol. Genet. 16, 1951-1958 (2007).
31. Risch, N. & Merikangas, K. The future of genetic studies of complex human diseases. Science 273, 1516-1517 (1996).
32. Koeleman, B.P., Dudbridge, F., Cordell, H.J. & Todd, J.A. Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the Conditional Extended Transmission/ Disequilibrium Test. Ann. Hum. Genet. 64, 207-213 (2000).
33. Gregersen, J.W. et al. Functional epistasis on a common MHC haplotype associated with multiple sclerosis. Nature 443, 574-577 (2006).
34. + cytotoxic T lymphocytes restricted by HLA-A3: evidence for cross-reactivity with an environmental microorganism. J. Neuroimmunol. 73, 7-14 (1997).
35. Klein, L., Klugmann, M., Nave, K.A., Tuohy, V.K. & Kyewski, B. Shaping of the autoreactive T cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 6, 56-61 (2000).
36. Serafini, B. et al. Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J. Exp. Med. 204, 2899-2912 (2007).
37. Alam, S.M. & Gascoigne, N.R. Posttranslational regulation of TCR Vα allelic exclusion during T cell differentiation. J. Immunol. 160, 3883-3890 (1998).
38. McGargill, M.A., Derbinski, J.M. & Hogquist, K.A. Receptor editing in developing T cells. Nat. Immunol. 1, 336-341 (2000).
39. Sim, B.C. et al. Thymic skewing of the CD4/CD8 ratio maps with the T cell receptor α-chain locus. Curr. Biol. 8, 701-704 (1998).
40. + multiple sclerosis. Eur. J. Immunol. 28, 3329-3335 (1998).
41. Vandenbark, A.A. et al. Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice. J. Immunol. 171, 127-133 (2003).
42. McMahon, E.J., Bailey, S.L., Castenada, C.V., Waldner, H. & Miller, S.D. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat. Med. 11, 335-339 (2005).
43. + T lymphocytes. Nature 421, 852-856 (2003).
44. Shedlock, D.J. & Shen, H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300, 337-339 (2003).
45. Sun, J.C. & Bevan, M.J. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300, 339-342 (2003).
46. Hogquist, K.A., Baldwin, T.A. & Jameson, S.C. Central tolerance: learning self-control in the thymus. Nat. Rev. Immunol. 5, 772-782 (2005).
47. Liston, A., Lesage, S., Wilson, J., Peltonen, L. & Goodnow, C.C. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4, 350-354 (2003).
48. + T lymphocytes from β2 microglobulin (β2m) HLA-A2.1 monochain transgenic H-2Db β2m double knockout mice. J. Exp. Med. 185, 2043-2051 (1997).
49. Vitiello, A., Marchesini, D., Furze, J., Sherman, L.A. & Chesnut, R.W. Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex. J. Exp. Med. 173, 1007-1015 (1991).
50. Madsen, L. et al. Mice lacking all conventional MHC class II genes. Proc. Natl. Acad. Sci. USA 96, 10338-10343 (1999).