Activation-induced cell death in T lymphocytes from multiple sclerosis patients

Journal of Neuroimmunology

Volumn 272, Issue 1-2, 2014, Pages 51-55

  Moreno, Montserrat ^a   Negrotto, Laura ^a   Río, Jordi ^a   Moubarak, Rana ^b   Martín, Isabel ^a   Bustamante, Marta F ^a   Comella, Joan X ^b   Vidal Jordana, Angela ^a   Pérez Boza, Jennifer ^a   Montalban, Xavier ^a   Comabella, Manuel ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Activation induced cell death; Apoptosis; Caspase 3; Fas; Multiple sclerosis; T lymphocytes

Indexed keywords

CASPASE 3; FAS ANTIGEN;

ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MALE; MIDDLE AGED; MOLECULAR DYNAMICS; MULTIPLE SCLEROSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ACTIVATION-INDUCED CELL DEATH; APOPTOSIS; CASPASE 3; FAS; MULTIPLE SCLEROSIS; T LYMPHOCYTES;

ADULT; ANTIGENS, CD; ANTIGENS, CD95; APOPTOSIS; CASPASE 3; CELLS, CULTURED; FEMALE; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PHYTOHEMAGGLUTININS; T-LYMPHOCYTES;

EID: 84901976684     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2014.04.007     Document Type: Article

References (21)

1. Bilinska M., Frydecka I., Podemski R., Teodorowska R., Gruszka E. Expression of Fas antigen on T cell subpopulations in peripheral blood of patients with relapsing-remitting multiple sclerosis. Med. Sci. Monit. 2001, 7:251-255.
2. Bilinska M., Frydecka I., Podemski R. Fas receptor expression on peripheral blood T lymphocytes in patients with secondary progressive multiple sclerosis. Pol. Merkur Lekarski 2003, 14:421-424.
3. Chan A., Weilbach F.X., Toyka K.V., Gold R. Mitoxantrone induces cell death in peripheral blood leucocytes of multiple sclerosis patients. Clin. Exp. Immunol. 2005, 139:152-158.
4. Comabella M., Khoury S.J. Immunopathogenesis of multiple sclerosis. Clin. Immunol. 2012, 142:2-8.
5. Comi C., Leone M., Bonissoni S., DeFranco S., Bottarel F., Mezzatesta C., Chiocchetti A., Perla F., Monaco F., Dianzani U. Defective T cell fas function in patients with multiple sclerosis. Neurology 2000, 55:921-927.
6. Garcia-Merino A., Barcenilla H., Diaz D., Monserrat J., Prieto A., Alvarez-Mon M. IFNbeta therapy progressively normalizes the increased ex vivo T lymphocyte apoptosis observed in active patients with multiple sclerosis. Clin. Immunol. 2009, 132:195-202.
7. Ichikawa H., Ota K., Iwata M. Increased Fas antigen on T cells in multiple sclerosis. J. Neuroimmunol. 1996, 71:125-129.
8. Ju S.T., Panka D.J., Cui H., Ettinger R., el Khatib M., Sherr D.H., Stanger B.Z., Marshak-Rothstein A. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 1995, 373:444-448.
9. Julia E., Edo M.C., Horga A., Montalban X., Comabella M. Differential susceptibility to apoptosis of CD4+ T cells expressing CCR5 and CXCR3 in patients with MS. Clin. Immunol. 2009, 133:364-374.
10. Kurtzke J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983, 33:1444-1452.
11. Macchi B., Matteucci C., Nocentini U., Caltagirone C., Mastino A. Impaired apoptosis in mitogen-stimulated lymphocytes of patients with multiple sclerosis. Neuroreport 1999, 10:399-402.
12. McFarland H.F., Martin R. Multiple sclerosis: a complicated picture of autoimmunity. Nat. Immunol. 2007, 8:913-919.
13. Okuda Y., Apatoff B.R., Posnett D.N. Apoptosis of T cells in peripheral blood and cerebrospinal fluid is associated with disease activity of multiple sclerosis. J. Neuroimmunol. 2006, 171:163-170.
14. Pender M.P. Activation-induced apoptosis of autoreactive and alloreactive T lymphocytes in the target organ as a major mechanism of tolerance. Immunol. Cell Biol. 1999, 77:216-223.
15. Petcu I., Savu D., Thierens H., Nagels G., Vral A. In vitro radiosensitivity of peripheral blood lymphocytes in multiple sclerosis patients. Int. J. Radiat. Biol. 2006, 82:793-803.
16. Polman C.H., Reingold S.C., Banwell B., Clanet M., Cohen J.A., Filippi M., Fujihara K., Havrdova E., Hutchinson M., Kappos L., Lublin F.D., Montalban X., O'Connor P., Sandberg-Wollheim M., Thompson A.J., Waubant E., Weinshenker B., Wolinsky J.S. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann. Neurol. 2011, 69:292-302.
17. Prieto A., Diaz D., Barcenilla H., Castrillo C., Monserrat J., Merino A.G., Alvarez-Mon M. Increased spontaneous ex vivo apoptosis and subset alterations in peripheral blood T cells from patients with multiple sclerosis. J. Clin. Immunol. 2006, 26:101-112.
18. Rieks M., Hoffmann V., Aktas O., Juschka M., Spitzer I., Brune N., Schimrigk S., Przuntek H., Pohlau D. Induction of apoptosis of CD4+ T cells by immunomodulatory therapy of multiple sclerosis with glatiramer acetate. Eur. Neurol. 2003, 50:200-206.
19. Ruggieri M., Avolio C., Scacco S., Pica C., Lia A., Zimatore G.B., Papa S., Livrea P., Trojano M. Glatiramer acetate induces pro-apoptotic mechanisms involving Bcl-2, Bax and Cyt-c in peripheral lymphocytes from multiple sclerosis patients. J. Neurol. 2006, 253:231-236.
20. Sharief M.K. Impaired Fas-independent apoptosis of T lymphocytes in patients with multiple sclerosis. J. Neuroimmunol. 2000, 109:236-243.
21. Zhang J., Xu X., Liu Y. Activation-induced cell death in T cells and autoimmunity. Cell. Mol. Immunol. 2004, 1:186-192.