A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins

Human Molecular Genetics

Volumn 10, Issue 19, 2001, Pages 2025-2037

  Cucca, Francesco ^a   Lampis, Rosannna ^a   Congia, Mauro ^a   Angius, Efisio ^b   Nutland, Sarah ^c   Bain, Stephen C ^d   Barnett, Anthony H ^d   Todd, John A ^c,e  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b BROTZU HOSPITAL   (Italy)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^e ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; EPITOPE; HLA ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; IA ANTIGEN; IE ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ALLELE; ALLOTYPE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHILD; CONTROLLED STUDY; CORRELATION FUNCTION; CRYSTAL STRUCTURE; DISEASE PREDISPOSITION; DISEASE RESISTANCE; GENETIC CONSERVATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTECTION; PROTEIN BINDING; PROTEIN STRUCTURE; PUBLICATION; RISK; SEQUENCE HOMOLOGY; SPECIES;

ANIMALIA; MURINAE;

EID: 0034777837     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.19.2025     Document Type: Article

References (66)

1. Assessing the role of HLA-linked and unlinked determinants of disease
2. Genetic analysis of type 1 diabetes using whole genome approaches
3. HLA/MHC: Genes, Molecules and Function
4. The role of HLA class II genes in insulin-dependent diabetes mellitus: Molecular analysis of 180 Caucasian, multiplex families
5. HLA and insulin-dependent diabetes. A protective perspective
6. Insulin-dependent diabetes mellitus
7. Molecular basis for HLA-DQ associations with IDDM
8. Molecular basis of celiac disease
9. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
10. A unified hypothesis for the complex genetics of HLA associations with IDDM
11. Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of IDDM
12. Molecular modelling of HLA-DQ suggests a mechanism of resistance in type 1 diabetes
13. A mechanism for the major histocompatibility complex-linked resistance to autoimmunity
14. Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response
15. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
16. Crystal structure of I-Ak in complex with a dominant epitope of lysozyme
17. Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues
18. A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes
19. Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice
20. A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus
21. The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase
22. The peptide binding motif of the disease associated HLA-DQ (alpha 1*0501, beta 1*0201) molecule
23. Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase
24. Prevention of diabetes in NOD mice by a mutated I-Ab transgene
25. X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II
26. Effect of natural polymorphism at residue 86 of the HLA-DR beta chain on peptide binding
27. Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice
28. The British Diabetic Association - Warren Repository
29. Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in Sardinia
30. Family cell lines available for research
31. Structure of the human class I histocompatibility antigen, HLA-A2
32. HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM
33. A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles
34. HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families
35. The distribution of DR4 haplotypes in Sardinia suggests a primary association of type I diabetes with DRB1 and DQB1 loci
36. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes
37. The NOD mouse: Recessive diabetogenic gene in the major histocompatibility complex
38. The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique
39. Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain
40. Direct evidence for the contribution of the unique I-A NOD to the development of insulitis in non-obese diabetic mice
41. Prevention of diabetes in non-obese diabetic I-Ak transgenic mice
42. An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells
43. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities
44. Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs
45. Autoreactivity of T cells from nonobese diabetic mice: An I-Ag7-dependent reaction
46. Peripheral-antigen-expressing cells in thymic medulla: Factors in self-tolerance and autoimmunity
47. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
48. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
49. A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin
50. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
51. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library
52. HLA associations in type 1 diabetes among patients not carrying high risk DR3-DQ2 or DR4-DQ8 haplotypes
53. The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese
54. Genetics of IDDM: Evidence for complex inheritance with HLA
55. Allelic sequence variation of the HLA-DQ loci: Relationship to serology and to insulin-dependent diabetes susceptibility
56. HLA-DR typing using DNA amplification by the polymerase chain reaction and sequential hybridization to sequence-specific oligonucleotide probes
57. Rapid typing of HLA-DQB1 DNA polymorphism using nonradioactive oligonucleotide probes and amplified DNA
58. HLA-DQB1*0305 and -DQB1*0304 alleles among Sardinians. Evolutionary and practical implications for oligotyping
59. Ten HLA-DR4 alleles defined by sequence polymorphisms within the DRB1 first domain
60. The PCR-SSP Manager computer program: A tool for maintaining sequence alignments and automatically updating the specificities of PCR-SSP primers and primer mixes
61. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
62. The HLA-DPB1-associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1
63. Detecting disease-predisposing variants: The haplotype method
64. The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases
65. Mapping disease genes: Family-based association studies
66. Structures of an MHC class II molecule with covalently bound single peptides