Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

Nature Medicine

Volumn 3, Issue 10, 1997, Pages 1133-1136

  Miller, Stephen D ^a   Vanderlugt, Carol L ^a   Begolka, Wendy Smith ^a   Pao, Winnie ^a   Yauch, Robert L ^a   Neville, Katherine L ^a   Katz Levy, Yael ^a   Carrizosa, Ana ^b   Kim, Byung S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN PROTEIN; PROTEOLIPID PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CENTRAL NERVOUS SYSTEM INFECTION; DEMYELINATING DISEASE; ETIOLOGY; FEMALE; IMMUNOPATHOGENESIS; MOUSE; MULTIPLE SCLEROSIS; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PICORNAVIRUS; PRIORITY JOURNAL; RNA VIRUS INFECTION; VIRUS PATHOGENESIS;

AMINO ACID SEQUENCE; ANIMALS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CROSS REACTIONS; DEMYELINATING DISEASES; EPITOPES; FEMALE; INFLAMMATION; KINETICS; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; MYELIN PROTEINS; MYELIN PROTEOLIPID PROTEIN; POLIOMYELITIS; SELF TOLERANCE; T-LYMPHOCYTES; THEILOVIRUS;

EID: 0030796646     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1097-1133     Document Type: Article

References (20)

1. Wekerle, H. Immunopathogenesis of multiple sclerosis. Acta Neurol. 13, 197-204 (1991).
2. Kurtzke, J.F. Epidemiologic evidence for multiple sclerosis as an infection. Clin. Microbiol. Rev. 6, 382-427 (1993).
3. Miller, S.D. & Gerety, S.J. Immunologic aspects of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. Semin. Virol. 1, 263-272 (1990).
4. Clatch, R.J., Lipton, H.L. & Miller, S.D. Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: Correlation with clinical signs, J. Immunol. 136, 920-927 (1986).
5. Clatch, R.J., Miller, S.D., Metzner, R., Dal Canto, M.C. & Lipton, H.L. Monocytes/ macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV). Virology 176, 244-254 (1990).
6. + T cell-mediated pathology. J. Immunol. 156, 4050-4058 (1996).
7. Fujinami, R.S. & Oldstone, M.B. Amino acid homology between the encephalito-genic site of myelin basic protein and virus: Mechanism for autoimmunity. Science 230, 1043-1045 (1985).
8. Wucherpfennig, K.W. & Strominger, J.L. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein. Cell 80, 695-705 (1995).
9. Lehmann, P.V., Forsthuber, T., Miller, A. & Sercarz, E.E. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358, 155-157 (1992).
10. McRae, B.L., Vanderlugt, C.L., Dal Canto, M.C. & Miller, S.D. Functional evidence for epitope spreading in the relapsing pathology of EAE in the SJL/J mouse. J. Exp. Med. 182, 75-85 (1995).
11. Ota, K. et al. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 346, 183-187 (1990).
12. Bernard, C.C. & de Rosbo, N.K. Immunopathological recognition of autoantigens in multiple sclerosis. Acta Neurol. 13, 171-178 (1991).
13. Scherer, M.T., Ignatowicz, L., Winslow, G.M., Kappler, J.W. & Marrack, P. Super-antigens: Bacterial and viral proteins that manipulate the immune system. Annu. Rev. Cell Biol. 9, 101-128 (1993).
14. Miller, S.D., Clatch, R.J., Pevear, D.C., Trotter, J.L. & Lipton, H.L. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Cross-specificity among TMEV substrains and related picornaviruses, but not myelin proteins. J. Immunol. 138, 3776-3784 (1987).
15. Kennedy, M.K. et al. Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides. J. Immunol. 144, 909-915 (1990).
16. Karpus, W.J., Pope, J.C., Peterson, J.D., Dal Canto, M.C. & Miller, S.D. Inhibition of Theiler's virus-mediated demyelination by peripheral immune tolerance induction, J. Immunol. 155, 947-957 (1995).
17. Miller, S.D. et al. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. III. Failure of neuroantigenspecific immune tolerance to affect the clinical course of demyelination. J. Neuroimmunol. 26, 9-23 (1990).
18. Yu, M., Johnson, J.M. & Tuohy, V.K. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: A basis for peptide-specific therapy after onset of clinical disease. J. Exp. Med. 183, 1777-1788 (1996).
19. Rose, N.R. & Hill, S.L. The pathogenesis of postinfectious myocarditis. Clin. Immunol. Immunopathol. 80, S92-S99 (1996).
20. Kyu, B. et al. Cardiac persistence of cardioviral RNA detected by polymerase chain reaction in a murine model of dilated cardiomyopathy. Circulation 86, 522-530 (1992).