T cell response to two immunodominant proteolipid protein (PLP) peptides in multiple sclerosis patients and healthy controls

Multiple Sclerosis

Volumn 1, Issue 5, 1996, Pages 270-278

  Pelfrey, C M ^a,c   Tranquill, L R ^a   Vogt, A B ^b   McFarland, H F ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Cytotoxic t lymphocytes; HLA DR2; Myelin basic protein; Proteolipid protein

Indexed keywords

EPITOPE; HLA DR ANTIGEN; NEUROPEPTIDE; PROTEOLIPID PROTEIN;

AMINO ACID SEQUENCE; ANTIBODY PRODUCTION; ARTICLE; BINDING COMPETITION; BLOOD; CASE CONTROL STUDY; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; MULTIPLE SCLEROSIS; REFERENCE VALUE; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANTIBODY FORMATION; BINDING, COMPETITIVE; CASE-CONTROL STUDIES; HLA-DR ANTIGENS; HUMANS; IMMUNODOMINANT EPITOPES; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; MYELIN PROTEOLIPID PROTEIN; NEUROPEPTIDES; REFERENCE VALUES; T-LYMPHOCYTES;

EID: 0030112686     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/135245859600100503     Document Type: Article

References (24)

1. Martin R, McFarland HF, McFarlin DE. (1992) Immunological aspects of demyelinating diseases. Ann Rev Immunol 10: 153-187.
2. Zamvil SS, Steinman L. (1990) The T lymphocyte in experimental allergic encephalomyelitis. Annu Rev Immunol 8: 579-621.
3. Lees MB, Macklin WB. (1988) Myelin proteolipid protein. In: Marangos PJ, Campbell IC, Cohen RM eds. Neuronal and Glial Proteins: Structure, Function and Clinical Application. Orlando: Academic Press, pp 267-294.
4. Selmaj K et al. (1991) Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin. J Immunol 147: 1522-1529.
5. Yamamura T et al. (1986) Experimental allergic encephalomyelitis induced by proteolipid apoprotein in Lewis rats. J Neuroimmunol 12: 143-153.
6. Yoshimura T et al. (1985) Chronic experimental allergic encephalomyelitis in guinea pigs induced by proteolipid protein. J Neurol Sci 69: 47-58.
7. Trotter JL et al. (1987) Myelin proteolipid protein induces demyelinating disease in mice. J Neurol Sci 79: 173-188.
8. Puckett C et al. (1987) Myelin-specific proteolipid protein is expressed in myelinating Schwann cells but is not incorporated into myelin sheaths. J Neurosci Res 18: 511-518.
9. Agrawal HC, Agrawal D. (1991) Proteolipid protein and DM-20 are synthesized by Schwann cells, present in myelin membrane, but they are not fatty acylated. Neurochem Res 16: 855-858.
10. Trotter JL, Lieberman L, Margolis FL, Agrawal HC. (1981) Radioimmunoassay for central nervous system myelin-specific proteolipid protein. J Neurochem 36: 1256-1262.
11. Kennedy MK et al. (1990) Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides. J Immunol 144: 909-915.
12. Tabira T. (1988) Autoimmune demyelination in the central nervous system. Ann N Y Acad Sci 540: 187-201.
13. Johnson D et al. (1986) Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis. J Neuroimmunol 13: 99-108.
14. Ota K et al. (1990) T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 346: 183-187.
15. Kerlero de Rosbo N et al. (1993) Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J Clin Invest 92: 2602-2608.
16. Hafler DA, Benjamin DS, Burks J, Weiner HL. (1987) Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis. J Immunol 139: 68-72.
17. Trotter JL, Hickey WF, van der Veen RC, Sulze L. (1991) Peripheral blood mononuclear cells from multiple sclerosis patients recognize myelin proteolipid protein and selected peptides. J Neuroimmunol 33: 55-62.
18. Sun JB et al. (1991) Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur J Immunol 21: 1461-1468.
19. Pelfrey CM, Trotter JL, Tranquill LR, McFarland HF. (1993) Identification of a novel T cell epitope of human proteolipid protein (residues 40-60) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients. J Neuroimmunol 46: 33-42.
20. Zhang J et al. (1994) Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med 179: 973-984.
21. Pelfrey CM, Trotter JL, Tranquill LR, McFarland HF. (1994) Identification of a second T cell epitope of human proteolipid protein (residues 89-106) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients. J Neuroimmunol 53: 153-161.
22. Chou YK et al. (1992) Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis. J Neuroimmunol 38: 105-113.
23. Martin R et al. (1990) Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. J Immunol 145: 540-548.
24. Diehl AJ, Schaich M, Budzinski RM, Stoffel W. (1986) Individual exons encode the integral membrane domains of human proteolipid protein. Proc Natl Acad Sci USA 83: 9807-9811.