Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders

Brain

Volumn 122, Issue 1, 1999, Pages 27-39

  Dalmau, Josep ^a,c   Gultekin, S Humayun ^a,b   Voltz, Raymond ^a   Hoard, Rita ^a   DesChamps, Thomas ^a   Balmaceda, Casilda ^d   Batchelor, Tracy ^e   Gerstner, Elizabeth ^a   Eichen, Joseph ^a   Frennier, Jennifer ^a   Posner, Jerome B ^a,c   Rosenfeld, Myrna R ^a,b,c  

^a Box 226   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d New York Presbyterian Hospital Columbia University Medical Center   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Antineuronal antibody; Brain testis proteins; Cerebellar degeneration; Ma1; Paraneoplastic

Indexed keywords

AUTOANTIBODY; CD8 ANTIGEN; COMPLEMENTARY DNA; NERVE PROTEIN; PHOSPHOPROTEIN; PROTEIN;

ADULT; ARTICLE; AUTOPSY; BRAIN STEM; BREAST CANCER; CASE REPORT; CELL LOSS; CELL NUCLEUS; CEREBELLUM DISEASE; COLON CANCER; CYTOPLASM; DNA LIBRARY; DNA SEQUENCE; DYSPHAGIA; FEMALE; GERM CELL; GLIOSIS; HUMAN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MALE; MUSCLE WEAKNESS; NEUROLOGIC DISEASE; NORTHERN BLOTTING; NUCLEOLUS; NUCLEOTIDE SEQUENCE; PARANEOPLASTIC SYNDROME; PAROTID GLAND CANCER; PRIORITY JOURNAL; PURKINJE CELL; SERUM; T LYMPHOCYTE; TESTIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS; BASE SEQUENCE; BRAIN; BRAIN DISEASES; CLONING, MOLECULAR; EPITOPES; FEMALE; HUMANS; IMMUNE SERA; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NEOPLASMS; PARANEOPLASTIC SYNDROMES; RATS; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; TESTIS;

EID: 0032957526     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/122.1.27     Document Type: Article

References (47)

1. Adams MD, Kerlavage AR. Fleischmann RD. Fuldner RA, Bult CJ, Lee NH, et al. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Nature 1995; 377 (6547 Suppl): 3-174.
2. Anderson NE, Rosenblum MK, Posner JB. Paraneoplastic cerebellar degeneration: clinical-immunological correlations. Ann Neurol 1988; 24: 559-67.
3. Boel P, Wildmann C, Sensi ML, Brasseur R, Renauld JC, Coulie P, et al. BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. Immunity 1995; 2: 167-75.
4. Boon T, van der Bruggen P. Human tumor antigens recognized by T lymphocytes. [Review]. J Exp Med 1996; 183: 725-9.
5. Buckanovich RJ, Posner JB, Darnell RB. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. Neuron 1993; 11: 657-72.
6. Budde-Steffen C, Anderson NE, Rosenblum MK, Graus F, Ford D, Synek BJ, et al. An anti-neuronal autoantibody in paraneoplastic opsoclonus. Ann Neurol 1988; 23: 528-31.
7. Carpentier AF, Voltz RD, Deschamps T, Posner JB, Dalmau J, Rosenfeld MR. Absence of HuD gene mutations in paraneoplastic small cell lung cancer tissue. Neurology 1998; 4: 2819-24.
8. Cattoretti G, Pileri S, Parravicini C, Becker MH, Poggi S, Bifulco C, et al. Antigen unmasking on formalin-fixed, paraffin-embedded tissue sections [see comments]. J Pathol 1993; 171: 83-98. Comment in: J Pathol 1993; 171: 79-80, Comment in: J Pathol 1995; 176: 217-8.
9. Cattoretti G, Pileri S, Parravicini C, Becker MH, Poggi S, Bifulco C, et al. Antigen unmasking on formalin-fixed, paraffin-embedded tissue sections [see comments]. J Pathol 1993; 171: 83-98. Comment in: J Pathol 1993; 171: 79-80, Comment in: J Pathol 1995; 176: 217-8.
10. Cattoretti G, Pileri S, Parravicini C, Becker MH, Poggi S, Bifulco C, et al. Antigen unmasking on formalin-fixed, paraffin-embedded tissue sections [see comments]. J Pathol 1993; 171: 83-98. Comment in: J Pathol 1993; 171: 79-80, Comment in: J Pathol 1995; 176: 217-8.
11. Connor F, Wright E, Denny P, Koopman P, Ashworth A. The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse. Nucleic Acids Res 1995; 23: 3365-72.
12. Corradi JP, Yang C, Darnell JC, Dalmau J, Darnell RB. A post-transcriptional regulatory mechanism restricts expression of the paraneoplastic cerebellar degeneration antigen cdr2 to immune privileged tissues. J Neurosci 1997; 17: 1406-15.
13. Cross SH, Charlton JA, Nan X, Bird AP. Purification of CpG islands using a methylated DNA binding column. Nat Genet 1994; 6: 236-44.
14. Dalmau JO, Posner JB. Paraneoplastic syndromes affecting the nervous system. Semin Oncol 1997; 24: 318-28.
15. Dalmau J, Furneaux HM, Gralla RJ, Kris MG, Posner JB. Detection of the Anti-Hu antibody in the serum of patients with small cell lung cancer - a quantitative western blot analysis. Ann Neurol 1990; 27: 544-52.
16. Dalmau J, Graus F, Rosenblum MK, Posner JB. Anti-Hu-associated paraneoplastic encephalomyelitis/sensory neuronopathy. A clinical study of 71 patients. Medicine (Baltimore) 1992; 71: 59-72.
17. Dropcho EJ, Chen Y-T, Posner JB, Old LJ. Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration. Proc Natl Acad Sci USA 1987; 84: 4552-6.
18. Fathallah-Shaykh H, Wolf S, Wong E, Posner JB, Furneaux HM, et al. Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration. Proc Natl Acad Sci USA 1991; 88: 3451-4.
19. Furneaux HM, Rosenblum MK, Dalmau J, Wong E, Woodruff P, Graus F, et al. Selective expression of Purkinje-cell antigens in tumor tissue from patients with paraneoplastic cerebellar degeneration. N Engl J Med 1990; 322: 1844-51.
20. Gaugler B, van den Eynde B, van der Bruggen P, Romero R, Gaforio JJ, De Plaen E, et al. Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. J Exp Med 1994; 179: 921-30.
21. Graus F, Cordon-Cardo C, Posner JB. Neuronal antinuclear antibody in sensory neuronopathy from lung cancer. Neurology 1985; 35: 538-43.
22. Graus F, Dalmau J, Valldeoriola F, Ferrer I, Reñé R, Marin C, et al. Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin's disease. J Neuroimmunol 1997; 74: 55-61.
23. Greenlee JE. Is paraneoplastic cerebellar degeneration an immune-mediated condition? [abstract]. Ann Neurol 1982; 12: 103.
24. Greenlee JE, Brashear HR. Antibodies to cerebellar Purkinje cells in patients with paraneoplastic cerebellar degeneration and ovarian carcinoma. Ann Neurol 1983; 14: 609-13.
25. Haas GG Jr, D'Cruz OJ, De Bault LE. Distribution of human leukocyte antigen-ABC and -D/DR antigens in the unfixed human testis. Am J Reprod Immunol Microbiol 1988; 18: 47-51.
26. Henson RA, Hoffman HL, Urich H. Encephalomyelitis with carcinoma. Brain 1965; 88: 449-64.
27. Kozak M. An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. [Review]. Nucleic Acids Res 1987; 15: 8125-48.
28. Lang B, Vincent A. Autoimmunity to ion-channels and other proteins in paraneoplastic disorders. [Review]. Curr Opin Immunol 1996; 8: 865-71.
29. Lang B, Newsom-Davis J, Wray D, Vincent A, Murray N. Autoimmune aetiology for myasthenic (Eaton-Lambert) syndrome. Lancet 1981; 2: 224-6.
30. Lee LG, Connell CR, Woo SL, Cheng RD, McArdle BF, Fuller CW, et al. DNA sequencing with dye-labeled terminators and T7 DNA polymerase: effect of dyes and dNTPs on incorporation of dye-terminators and probability analysis of termination fragments. Nucleic Acids Res 1992; 20: 2471-83.
31. Luque FA, Furneaux HM, Ferziger R, Rosenblum MK, Wray SH, Schold SC, et al. Anti-Ri: an antibody associated with paraneoplastic opsoclonus and breast cancer. Ann Neurol 1991; 29: 241-51.
32. 3F12 SAP kinase. Brain Res Mol Brain Res 1996; 35: 47-57.
33. McLay RN, Banks WA, Kastin AJ. Granulocyte macrophage-colony stimulating factor crosses the blood-testis barrier in mice. Biol Reprod 1997; 57: 822-6.
34. Neumann H, Schmidt H, Cavalie A, Jenne D, Wekerle H. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha. J Exp Med 1997; 185: 305-16.
35. w18 deletion region expresses in germ cells and embryonic nervous system. Dev Biol 1993; 155: 409-22.
36. Peterson K, Rosenblum MK, Kotanides H, Posner JB. Paraneoplastic cerebellar degeneration. I. A clinical analysis of 55 anti-Yo antibody-positive patients. Neurology 1992; 42: 1931-7.
37. Posner JB, editor. Paraneoplastic syndromes. In: Posner JB. Neurologic complications of cancer. Philadelphia: FA. Davis; 1995. p. 353-85.
38. Sakai K, Mitchell DJ, Tsukamoto T, Steinman L. Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration [published erratum appears in Ann Neurol 1991; 30; 738]. Ann Neurol 1990; 28: 692-8.
39. Shillito P, Molenaar PC, Vincent A, Leys K, Zheng W, van den Berg RJ, et al. Acquired neuromyotonia: evidence for autoantibodies directed against K+ channels of peripheral nerves [see comments]. Ann Neurol 1995; 38: 714-22. Comment in: Ann Neurol 1995; 38: 701-2.
40. Shillito P, Molenaar PC, Vincent A, Leys K, Zheng W, van den Berg RJ, et al. Acquired neuromyotonia: evidence for autoantibodies directed against K+ channels of peripheral nerves [see comments]. Ann Neurol 1995; 38: 714-22. Comment in: Ann Neurol 1995; 38: 701-2.
41. Szabo A, Dalmau J, Manley G, Rosenfeld M, Wong E, Henson J, et al. HuD, a paraneoplastic encephalomyelitis antigen, contains RNA binding domains and is homologous to Elav and Sex-lethal. Cell 1991; 67: 325-33.
42. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979; 76: 4350-4.
43. Trotter JL, Hendin BA, Osterland CK. Cerebellar degeneration with Hodgkin disease. An immunological study. Arch Neurol 1976; 33: 660-1.
44. Van den Eynde B, Peelers O, De Backer O, Gaugler B, Lucas S, Boon T. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. J Exp Med 1995; 182: 689-98.
45. van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, van den Eynde B, et al. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 1991; 254: 1643-7.
46. Verschuuren J, Dalmau J. Paraneoplastic neurologic disorders. In: Antel J, Birnbaum G, Hartung H-P, editors. Clinical neuroimmunology. Maiden (MA): Blackwell Science; 1998. p. 148-71.
47. Voltz R, Gultekin HS, Posner JB, Rosenfeld MR, Dalmau J. Sera of patients with testicular cancer and paraneoplastic limbic/brainstem encephalitis harbor an antineuronal antibody (anti-Ta) that recognizes a novel neuronal protein [abstract]. J Neurol 1998; 245: 379.