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Volumn 8, Issue 4, 2007, Pages 351-358

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSCRIPTION FACTOR FOXP3;

EID: 34248598295     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1444     Document Type: Article
Times cited : (480)

References (52)
  • 1
    • 0029659049 scopus 로고    scopus 로고
    • Evidence for a thymus-dependent form of tolerance that is not based on elimination or energy of reactive T cells
    • Le Douarin, N. et al. Evidence for a thymus-dependent form of tolerance that is not based on elimination or energy of reactive T cells. Immunol. Rev. 149, 35-53 (1996).
    • (1996) Immunol. Rev , vol.149 , pp. 35-53
    • Le Douarin, N.1
  • 2
    • 0029835613 scopus 로고    scopus 로고
    • Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium
    • Modigliani, Y. et al. Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium. Eur. J. Immunol. 26, 1807-1815 (1996).
    • (1996) Eur. J. Immunol , vol.26 , pp. 1807-1815
    • Modigliani, Y.1
  • 3
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: More questions than answers. Nat. Rev. Immunol. 2, 389-400 (2002).
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 4
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • Maloy, K.J. & Powrie, F. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2, 816-822 (2001).
    • (2001) Nat. Immunol , vol.2 , pp. 816-822
    • Maloy, K.J.1    Powrie, F.2
  • 5
    • 2442484053 scopus 로고    scopus 로고
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22, 531-562 (2004).
    • (2004) Annu. Rev. Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 6
    • 7144259082 scopus 로고    scopus 로고
    • Regulatory CD4 T cells: Expression of IL-2Rα chain, resistance to clonal deletion and IL-2 dependency
    • Papiemik, M., de Moraes, M.L., Pontoux, C., Vasseur, F. & Penit, C. Regulatory CD4 T cells: Expression of IL-2Rα chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol. 10, 371-378 (1998).
    • (1998) Int. Immunol , vol.10 , pp. 371-378
    • Papiemik, M.1    de Moraes, M.L.2    Pontoux, C.3    Vasseur, F.4    Penit, C.5
  • 7
    • 0033136302 scopus 로고    scopus 로고
    • + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
    • + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162, 5317-5326 (1999).
    • (1999) J. Immunol , vol.162 , pp. 5317-5326
    • Itoh, M.1
  • 8
    • 33645102841 scopus 로고    scopus 로고
    • An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
    • Hsieh, C.S., Zheng, Y., Liang, Y., Fontenot, J.D. & Rudensky, A.Y. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7, 401-410 (2006).
    • (2006) Nat. Immunol , vol.7 , pp. 401-410
    • Hsieh, C.S.1    Zheng, Y.2    Liang, Y.3    Fontenot, J.D.4    Rudensky, A.Y.5
  • 10
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou, I., Sarukhan, A., Klein, L. & von Boehmer, H. Origin of regulatory T cells with known specificity for antigen. Nat Immunol. 3, 756-763 (2002).
    • (2002) Nat Immunol , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    von Boehmer, H.4
  • 11
    • 33744786828 scopus 로고    scopus 로고
    • + regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage
    • + regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage. Proc. Natl. Acad. Sci. USA 103, 8453-8458 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 8453-8458
    • Cabarrocas, J.1
  • 12
    • 0035320679 scopus 로고    scopus 로고
    • + regulatory T cells induced by an agonist self-peptide
    • + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2, 301-306 (2001).
    • (2001) Nat. Immunol , vol.2 , pp. 301-306
    • Jordan, M.S.1
  • 13
    • 0036568942 scopus 로고    scopus 로고
    • + regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression
    • + regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J. Immunol. 168, 4399-4405 (2002).
    • (2002) J. Immunol , vol.168 , pp. 4399-4405
    • Kawahata, K.1
  • 14
    • 0041806547 scopus 로고    scopus 로고
    • In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro
    • Klein, L., Khazaie, K. & von Boehmer, H. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA 100, 8886-8891 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8886-8891
    • Klein, L.1    Khazaie, K.2    von Boehmer, H.3
  • 15
    • 2942724435 scopus 로고    scopus 로고
    • + regulatory T cell repertoire formation in response to varying expression of a neo-self-antigen. J. Immunol. 173, 236-244 (2004).
    • + regulatory T cell repertoire formation in response to varying expression of a neo-self-antigen. J. Immunol. 173, 236-244 (2004).
  • 18
    • 25844504653 scopus 로고    scopus 로고
    • Developmental regulation of Foxp3 expression during ontogeny
    • Fontenot, J.D., Dooley, J.L., Farr, A.G. & Rudensky, A.Y. Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 202, 901-906 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 901-906
    • Fontenot, J.D.1    Dooley, J.L.2    Farr, A.G.3    Rudensky, A.Y.4
  • 19
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2, 1032-1039 (2001).
    • (2001) Nat. Immunol , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 20
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • Anderson, M.S. et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 298, 1395-1401 (2002).
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1
  • 23
    • 23844558032 scopus 로고    scopus 로고
    • The cellular mechanism of Aire control of T cell tolerance
    • Anderson, M.S. et al. The cellular mechanism of Aire control of T cell tolerance. Immunity 23, 227-239 (2005).
    • (2005) Immunity , vol.23 , pp. 227-239
    • Anderson, M.S.1
  • 24
    • 25844526684 scopus 로고    scopus 로고
    • Central tolerance: Learning self-control in the thymus
    • Hogquist, K.A., Baldwin, T.A. & Jameson, S.C. Central tolerance: learning self-control in the thymus. Nat. Rev. Immunol. 5, 772-782 (2005).
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 772-782
    • Hogquist, K.A.1    Baldwin, T.A.2    Jameson, S.C.3
  • 25
    • 2442567829 scopus 로고    scopus 로고
    • Back to central tolerance
    • Mathis, D. & Benoist, C. Back to central tolerance. Immunity 20 509-516 (2004).
    • (2004) Immunity , vol.20 , pp. 509-516
    • Mathis, D.1    Benoist, C.2
  • 26
    • 34248594710 scopus 로고    scopus 로고
    • A central role for central tolerance
    • Kyewski, B. & Klein, L. A central role for central tolerance. Annu. Rev. Immunol 20, 509-516 (2004).
    • (2004) Annu. Rev. Immunol , vol.20 , pp. 509-516
    • Kyewski, B.1    Klein, L.2
  • 27
    • 0342360011 scopus 로고    scopus 로고
    • On the intrathymic intercellular transfer of self-determinants
    • Viret, C., Barlow, A.K. & Janeway, C.A., Jr. On the intrathymic intercellular transfer of self-determinants. Immunol. Today 20 8-10 (1999).
    • (1999) Immunol. Today , vol.20 , pp. 8-10
    • Viret, C.1    Barlow, A.K.2    Janeway Jr., C.A.3
  • 28
    • 0028590184 scopus 로고
    • Presentation and intercellular transfer of self antigen within the thymic microenvironment: Expression of the Eα peptide-l-Ab complex by isolated thymic stromal cells
    • Humblet, C., Rudensky, A. & Kyewski, B. Presentation and intercellular transfer of self antigen within the thymic microenvironment: Expression of the Eα peptide-l-Ab complex by isolated thymic stromal cells. Int. Immunol. 6, 1949-1958 (1994).
    • (1994) Int. Immunol , vol.6 , pp. 1949-1958
    • Humblet, C.1    Rudensky, A.2    Kyewski, B.3
  • 29
    • 7244227645 scopus 로고    scopus 로고
    • Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
    • Gallegos, A.M. & Bevan, M.J. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 200, 1039-1049 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 1039-1049
    • Gallegos, A.M.1    Bevan, M.J.2
  • 30
    • 24144480562 scopus 로고    scopus 로고
    • + regulatory T cells in human thymus
    • + regulatory T cells in human thymus. Nature 436, 1181-1185 (2005).
    • (2005) Nature , vol.436 , pp. 1181-1185
    • Watanabe, N.1
  • 31
    • 33646162855 scopus 로고    scopus 로고
    • A unified theory of central tolerance in the thymus
    • Liu, Y.J. A unified theory of central tolerance in the thymus. Trends Immunol. 27, 215-221 (2006).
    • (2006) Trends Immunol , vol.27 , pp. 215-221
    • Liu, Y.J.1
  • 32
    • 29244435493 scopus 로고    scopus 로고
    • Inducing and expanding regulatory T cell populations by foreign antigen
    • Kretschmer, K. et al. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6, 1219-1227 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 1219-1227
    • Kretschmer, K.1
  • 33
    • 0035399985 scopus 로고    scopus 로고
    • +CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen
    • +CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 167, 188-195 (2001).
    • (2001) J. Immunol , vol.167 , pp. 188-195
    • Thorstenson, K.M.1    Khoruts, A.2
  • 35
    • 0035856960 scopus 로고    scopus 로고
    • Thymus medulla consisting of epithelial islets each derived from a single progenitor
    • Rodewald, H.R., Paul, S., Haller, C., Bluethmann, H. & Blum, C. Thymus medulla consisting of epithelial islets each derived from a single progenitor. Nature 414, 763-768 (2001).
    • (2001) Nature , vol.414 , pp. 763-768
    • Rodewald, H.R.1    Paul, S.2    Haller, C.3    Bluethmann, H.4    Blum, C.5
  • 36
    • 0031048826 scopus 로고    scopus 로고
    • Quantitative impact of thymic clonal deletion on the T cell repertoire
    • van Meerwijk, J.P. et al. Quantitative impact of thymic clonal deletion on the T cell repertoire. J. Exp. Med. 185, 377-383 (1997).
    • (1997) J. Exp. Med , vol.185 , pp. 377-383
    • van Meerwijk, J.P.1
  • 37
    • 22344449972 scopus 로고    scopus 로고
    • Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
    • Derbinski, J. et al. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J. Exp. Med. 202, 33-45 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 33-45
    • Derbinski, J.1
  • 38
    • 0028359368 scopus 로고
    • + single positive cells with a class II major histocompatibility complex-restricted receptor
    • + single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180, 25-34 (1994).
    • (1994) J. Exp. Med , vol.180 , pp. 25-34
    • Kirberg, J.1
  • 39
    • 0031058466 scopus 로고    scopus 로고
    • Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
    • Brocker, T., Riedinger, M. & Karjalainen, K. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J. Exp. Med. 185, 541-550 (1997).
    • (1997) J. Exp. Med , vol.185 , pp. 541-550
    • Brocker, T.1    Riedinger, M.2    Karjalainen, K.3
  • 40
    • 0030587960 scopus 로고    scopus 로고
    • Kinetics of generation and persistence on membrane class II molecules of a viral peptide expressed on foreign and self proteins
    • Bot, A., Bot, S., Antohi, S., Karjalainen, K. & Bona, C. Kinetics of generation and persistence on membrane class II molecules of a viral peptide expressed on foreign and self proteins. J. Immunol. 157 3436-3442 (1996).
    • (1996) J. Immunol , vol.157 , pp. 3436-3442
    • Bot, A.1    Bot, S.2    Antohi, S.3    Karjalainen, K.4    Bona, C.5
  • 41
    • 33745848463 scopus 로고    scopus 로고
    • Agonist ligands expressed by thymic epithelium enhance positive selection of regulatory T lymphocytes from precursors with a normally diverse TCR repertoire
    • Ribot, J., Romagnoli, P. & van Meerwijk, J.P. Agonist ligands expressed by thymic epithelium enhance positive selection of regulatory T lymphocytes from precursors with a normally diverse TCR repertoire. J. Immunol. 177, 1101-1107 (2006).
    • (2006) J. Immunol , vol.177 , pp. 1101-1107
    • Ribot, J.1    Romagnoli, P.2    van Meerwijk, J.P.3
  • 42
    • 33745516115 scopus 로고    scopus 로고
    • Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium
    • Rossi, S.W., Jenkinson, W.E., Anderson, G. & Jenkinson, E.J. Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium. Nature 441, 988-991 (2006).
    • (2006) Nature , vol.441 , pp. 988-991
    • Rossi, S.W.1    Jenkinson, W.E.2    Anderson, G.3    Jenkinson, E.J.4
  • 43
    • 33745532385 scopus 로고    scopus 로고
    • Formation of a functional thymus initiated by a postnatal epithelial progenitor cell
    • Bleul, C.C. et al. Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature 441, 992-996 (2006).
    • (2006) Nature , vol.441 , pp. 992-996
    • Bleul, C.C.1
  • 44
    • 16444377660 scopus 로고    scopus 로고
    • Dependence of self-tolerance on TRAF6-directed development of thymic stroma
    • Akiyama, T. et al. Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308, 248-251 (2005).
    • (2005) Science , vol.308 , pp. 248-251
    • Akiyama, T.1
  • 45
    • 33748460821 scopus 로고    scopus 로고
    • TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis
    • King, C.G. et al. TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat. Med. 12, 1088-1092 (2006).
    • (2006) Nat. Med , vol.12 , pp. 1088-1092
    • King, C.G.1
  • 46
    • 0034857910 scopus 로고    scopus 로고
    • Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance
    • Klein, L., Roettinger, B. & Kyewski, B. Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance. Eur. J. Immunol. 31, 2476-2486 (2001).
    • (2001) Eur. J. Immunol , vol.31 , pp. 2476-2486
    • Klein, L.1    Roettinger, B.2    Kyewski, B.3
  • 48
    • 0033682056 scopus 로고    scopus 로고
    • + immunoregulatory T cells that control autoimmune diabetes
    • + immunoregulatory T cells that control autoimmune diabetes. Immunity 12, 431-440 (2000).
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 49
    • 13944260538 scopus 로고    scopus 로고
    • Tai, X., Cowan, M., Feigenbaum, L. & Singer, A. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6 152-162 (2005).
    • Tai, X., Cowan, M., Feigenbaum, L. & Singer, A. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6 152-162 (2005).
  • 50
    • 0033526862 scopus 로고    scopus 로고
    • Several different cell surface molecules control negative selection of medullary thymocytes
    • Kishimoto, H. & Sprent, J. Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190, 65-73 (1999).
    • (1999) J. Exp. Med , vol.190 , pp. 65-73
    • Kishimoto, H.1    Sprent, J.2
  • 51
    • 9244244736 scopus 로고    scopus 로고
    • Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    • van Santen, H.M., Benoist, C. & Mathis, D. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 200, 1221-1230 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 1221-1230
    • van Santen, H.M.1    Benoist, C.2    Mathis, D.3
  • 52
    • 33646181015 scopus 로고    scopus 로고
    • Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: Role of TSLP
    • Jiang, Q., Su, H., Knudsen, G., Helms, W. & Su, L. Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: Role of TSLP. BMC Immunol. 7, 6 (2006).
    • (2006) BMC Immunol , vol.7 , pp. 6
    • Jiang, Q.1    Su, H.2    Knudsen, G.3    Helms, W.4    Su, L.5


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