Bystander CD8 T cell-mediated demyelination after viral infection of the central nervous system

Journal of Immunology

Volumn 169, Issue 3, 2002, Pages 1550-1555

  Haring, Jodie S ^a   Pewe, Lecia L ^a   Perlman, Stanley ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BYSTANDER EFFECT; CENTRAL NERVOUS SYSTEM INFECTION; CONTROLLED STUDY; DEMYELINATION; DISEASE COURSE; DISEASE EXACERBATION; ENCEPHALITIS; HEPATITIS VIRUS; IMMUNOSTIMULATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RELAPSE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

EID: 0036681780     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.3.1550     Document Type: Article

References (40)

1. Molecule mimicry by herpes simplex virus-type 1: Autoimmune disease after viral infection
2. Studies on autoimmunity for T-cell-mediated β-cell destruction
3. Relation of antecedent illness to development of diabetes in children
4. Chlamydia infections and heart disease linked through antigenic mimicry
5. Role of bacterial infection in exacerbation of multiple sclerosis
6. Clinical viral infections and multiple sclerosis
7. Clinical relapses and disease activity on magnetic resonance imaging associated with viral upper respiratory tract infections in multiple sclerosis
8. Influence of infection on exacerbations of multiple sclerosis
9. Multiple sclerosis
10. Viruses as triggers of autoimmunity: Facts and fantasies
11. Mouse hepatitis virus
12. Pathogenesis of coronavirus-induced infections: Review of pathological and immunological aspects
13. Macrophage infiltration, but not apoptosis, is correlated with immune-mediated demyelination following murine infection with a neurotropic coronavirus
14. Pathogenesis of mouse hepatitis virus-induced demyelination
15. CD4 and CD8 T cells have redundant but not identical roles in virus-induced demyelination
16. Traffic of hematogenous cells through the central nervous system
17. T-cell apoptosis in inflammatory brain lessions: Destruction of T cells does not depend on antigen recognition
18. Naive T lymphocytes traffic to inflamed central nervous system, but require antigen recognition for activation
19. In situ tolerance with the central nervous system as mechanism for preventing autoimmunity
20. Selection of CTL escape mutants in mice infected with a neurotropic coronavirus: Qualitative estimate of TCR diversity in the infected CNS
21. Immune response to the immunodominant epitope of mouse hepatitis virus is polyclonal, but functionally monospecific in C57BL/6 mice
22. High magnitude, virus-specific CD4 T-cell response in the central nervous system of coronavirus-infected mice
23. Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis
24. Depletion of blood-bome macrophages does not reduce demyelination in mice infected with a neurotropic coronavirus
25. Activation of cerebral cytokine gene expression and its correlation with onset of reactive astrocyte and acute-phase response gene expression in scrapie
26. Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor
27. Dynamic regulation of α- and β-chemokine expression in the central nervous system during mouse hepatitis vires-induced demyelinating disease
28. Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus
29. Evolution of the T cell repertoire during primary, memory, and recall responses to viral infection
30. + T cell development
31. + T-cells and RANTES in virus-induced central nervous system inflammation and demyelination
32. The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease
33. Expression of Mig (monokine induced by interferon-γ) is important in T lymphocyte recruitment and host defense following viral infection of the central nervous system
34. Assessment of animal models for MS and demyelinating disease in the design of rational therapy
35. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients
36. Bystander activation involving T lymphocytes in herpetic stromal keratitis
37. + T cells in a model for multiple sclerosis
38. Cutting edge: CD8 T cell-mediated demyelination is IFN-γ dependent in mice infected with a neurotropic coronavirus
39. + T cells
40. Cytokines and immunity to viral infections