Computational protein engineering: Bridging the gap between rational design and laboratory evolution

International Journal of Molecular Sciences

Volumn 13, Issue 10, 2012, Pages 12428-12460

  Barrozo, Alexandre ^a   Borstnar, Rok ^a,b   Marloie, Gaël ^a   Kamerlin, Shina Caroline Lynn ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

Author keywords

Computational enzymology; De novo enzyme design; Directed evolution; Enzyme redesign; Protein engineering

Indexed keywords

ALLOSTERISM; CATALYSIS; CHEMICAL BOND; COMPUTER MODEL; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME STABILITY; HYDROPHOBICITY; LABORATORY; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PROCESS DESIGN; PROCESS DEVELOPMENT; PROTEIN ENGINEERING; REVIEW; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; BIOLOGY; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; ENZYME ACTIVE SITE; GENETICS; KINETICS; METABOLISM; QUANTUM THEORY;

ENZYME;

CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; DIRECTED MOLECULAR EVOLUTION; ENZYMES; KINETICS; MOLECULAR DYNAMICS SIMULATION; PROTEIN ENGINEERING; QUANTUM THEORY;

EID: 84867777175     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms131012428     Document Type: Review

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