Structural origins of efficient proton abstraction from carbon by a catalytic antibody

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 14, 2005, Pages 4984-4989

  Debler, Erik W ^a   Ito, Shuichiro ^a   Seebeck, Florian P ^b   Heine, Andreas ^a,c   Hilvert, Donald ^b   Wilson, Ian A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ETH ZURICH   (Switzerland)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Base catalysis; Crystal structure; Medium effects; Orientation effects; Proton transfer

Indexed keywords

ANTIBODY; BENZIMIDAZOLE DERIVATIVE; BENZISOXAZOLE DERIVATIVE; CARBON; CARBOXYLIC ACID; GLUTAMIC ACID; GUANIDINE; HAPTEN; NITRILE; OXAZOLE DERIVATIVE; OXYGEN; PROTON; SALICYLIC ACID DERIVATIVE; SALICYLONITRILE DERIVATIVE; TRYPTOPHAN; UNCLASSIFIED DRUG; WATER;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; HYDROGEN BOND; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTON TRANSPORT; SOLVATION;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, CATALYTIC; BENZIMIDAZOLES; BINDING SITES, ANTIBODY; CARBON; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; HAPTENS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTONS; RECOMBINANT FUSION PROTEINS; VARIATION (GENETICS);

EID: 17044431448     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0409207102     Document Type: Article

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