Exploring protein fitness landscapes by directed evolution

Nature Reviews Molecular Cell Biology

Volumn 10, Issue 12, 2009, Pages 866-876

  Romero, Philip A ^a   Arnold, Frances H ^a  

^a California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CYTOCHROME P450; ENZYME; PROTEIN;

ADAPTATION; AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; BACTERIUM; BIODIVERSITY; CROSS LINKING; DIRECTED MOLECULAR EVOLUTION; EPISTASIS; EVOLUTION; FOSSIL; GENE MUTATION; GENETIC VARIABILITY; HIGH THROUGHPUT SCREENING; LANDSCAPE; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEOMICS; REVIEW;

ANIMALS; DIRECTED MOLECULAR EVOLUTION; HUMANS; MUTATION; PROTEINS;

EID: 70450242805     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm2805     Document Type: Review

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