Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 34, 2011, Pages 14115-14120

  Adamczyk, Andrew J ^a   Cao, Jie ^a   Kamerlin, Shina C L ^b   Warshel, Arieh ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE;

ARTICLE; CALCULATION; CATALYSIS; COMPUTER SIMULATION; ELECTROSTATIC PRECIPITATION; ENTROPY; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME MECHANISM; MOLECULAR BIOLOGY; MUTATION; PRIORITY JOURNAL; REPRODUCIBILITY; SURFACE PROPERTY;

BIOCATALYSIS; ENTROPY; MODELS, MOLECULAR; PLIABILITY; PROTEIN CONFORMATION; STATIC ELECTRICITY; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 80052149070     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1111252108     Document Type: Article

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