Testing electrostatic complementarity in enzyme catalysis: Hydrogen bonding in the ketosteroid isomerase oxyanion hole

PLoS Biology

Volumn 4, Issue 4, 2006, Pages 501-519

  Kraut, Daniel A ^a   Sigala, Paul A ^a   Pybus, Brandon ^b   Liu, Corey W ^a   Ringe, Dagmar ^b   Petsko, Gregory A ^b   Herschlag, Daniel ^a  

^a STANFORD UNIVERSITY   (United States)

^b BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHENOL DERIVATIVE; PROTON; STEROID DELTA ISOMERASE; ANION; HYDROXYBENZOIC ACID DERIVATIVE; ISOMERASE; OXYGEN; PHENOLIC ACID;

ARTICLE; BINDING AFFINITY; CATALYSIS; ELECTRICITY; ENTHALPY; ENZYME MECHANISM; GEOMETRY; HYDROGEN BOND; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PKA; PROTON NUCLEAR MAGNETIC RESONANCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMAMONAS TESTOSTERONI; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN TERTIARY STRUCTURE; PSEUDOMONAS PUTIDA; SOLUTION AND SOLUBILITY; X RAY CRYSTALLOGRAPHY;

ANIONS; BINDING SITES; CARBON-CARBON DOUBLE BOND ISOMERASES; CATALYSIS; COMAMONAS TESTOSTERONI; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; HYDROGEN BONDING; HYDROXYBENZOIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OXYGEN; PROTEIN STRUCTURE, TERTIARY; PSEUDOMONAS PUTIDA; SOLUTIONS; SUBSTRATE SPECIFICITY;

EID: 33646262869     PISSN: 15457885     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.0040099     Document Type: Article

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