Challenges and advances in validating enzyme design proposals: The case of kemp eliminase catalysis

Biochemistry

Volumn 50, Issue 18, 2011, Pages 3849-3858

  Frushicheva, Maria P ^a   Cao, Jie ^a   Warshel, Arieh ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC EFFECTS; DESIGN PROPOSAL; ENZYME CATALYSIS; KEY FACTORS; LINEAR FREE ENERGY RELATIONSHIPS; OVER CURRENT; PREORGANIZATION; RECENT PROGRESS; SCREENING TOOL; VALENCE BONDS;

CATALYSIS; CATALYSTS; DESIGN;

ENZYMES;

ENZYME; KEMP ELIMINASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPUTER AIDED DESIGN; ELIMINATION REACTION; LINEAR ENERGY TRANSFER; LINEAR FREE ENERGY RELATIONSHIP; MATHEMATICAL COMPUTING; MUTATION; PRIORITY JOURNAL; STATIC ELECTRICITY;

4-CHLORO-7-NITROBENZOFURAZAN; ANIMALS; BIOCHEMISTRY; CARBOXYLIC ACIDS; CATALYSIS; ENZYMES; HUMANS; HYDROGEN-ION CONCENTRATION; INTRAMOLECULAR OXIDOREDUCTASES; LYASES; MICE; MODELS, CHEMICAL; PROTEIN CONFORMATION; PROTEIN ENGINEERING; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 79955625862     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200063a     Document Type: Article

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