Improving catalytic function by ProSAR-driven enzyme evolution

Nature Biotechnology

Volumn 25, Issue 3, 2007, Pages 338-344

  Fox, Richard J ^a   Davis, S Christopher ^a   Mundorff, Emily C ^a   Newman, Lisa M ^a   Gavrilovic, Vesna ^a   Ma, Steven K ^a   Chung, Loleta M ^a   Ching, Charlene ^a   Tam, Sarena ^a   Muley, Sheela ^a   Grate, John ^a   Gruber, John ^a   Whitman, John C ^a   Sheldon, Roger A ^b   Huisman, Gjalt W ^a  

^a R and D Project Development and Management   (United States)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CHOLESTEROL; DRUG PRODUCTS; MUTAGENESIS;

BIOCATALYTIC PROCESS; ENZYME OPTIMIZATION; PROTEIN SEQUENCE ACTIVITY RELATIONSHIPS (PROSAR); VOLUMETRIC PRODUCTIVITY;

ENZYME KINETICS;

ATORVASTATIN;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; DRUG SYNTHESIS; ENZYME DEGRADATION; GENE FUNCTION; GENETIC VARIABILITY; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENCE ANALYSIS; STATISTICAL ANALYSIS;

ALGORITHMS; ANTICHOLESTEREMIC AGENTS; BACTERIA; CATALYSIS; DIRECTED MOLECULAR EVOLUTION; HEPTANOIC ACIDS; HYDROLASES; KINETICS; MOLECULAR SEQUENCE DATA; PROTEINS; PYRROLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS);

EID: 33947095042     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1286     Document Type: Article

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