Simulating the effect of DNA polymerase mutations on transition-state energetics and fidelity: Evaluating amino acid group contribution and allosteric coupling for ionized residues in human pol β

Biochemistry

Volumn 45, Issue 23, 2006, Pages 7036-7048

  Xiang, Yun ^a   Oelschlaeger, Peter ^a   Florián, Jan ^b   Goodman, Myron F ^a   Warshel, Arieh ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APPROXIMATION THEORY; BINDING ENERGY; CATALYSIS; DNA; IONIZATION; MUTAGENESIS;

DNA POLYMERASE; LINEAR RESPONSE APPROXIMATION (LRA); MUTATIONAL EFFECTS; TRANSITION-STATE ENERGETICS;

ENZYMES;

AMINO ACID; DNA; DNA DIRECTED DNA POLYMERASE BETA; DNA POLYMERASE; MAGNESIUM ION;

ALLOSTERISM; AMINO ACID ANALYSIS; ARTICLE; BASE PAIRING; BINDING SITE; CALCULATION; CATALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DESIGN; ENERGY TRANSFER; ENZYME ANALYSIS; GENE MUTATION; HUMAN; IONIZATION; LINEAR RESPONSE APPROXIMATION; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; STEADY STATE; THERMODYNAMICS; TRANSITION STATE BINDING ENERGY;

EID: 33745052090     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060147o     Document Type: Article

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