Industrial biocatalysis today and tomorrow

Nature

Volumn 409, Issue 6817, 2001, Pages 258-268

  Schmid, A ^a   Dordick, J S ^b   Hauer, B ^c   Kiener, A ^d   Wubbolts, M ^e   Witholt, B ^a  

^a ETH ZURICH   (Switzerland)

^b RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^c BASF SE   (Germany)

^d LONZA AG   (Switzerland)

^e DSM Deutschland GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ORGANIC COMPOUND; ORGANIC SOLVENT;

AQUEOUS SOLUTION; CATALYSIS; ENZYME MECHANISM; PRIORITY JOURNAL; REACTION ANALYSIS; REVIEW; SOLUBILITY; SYNTHESIS;

CATALYSIS; CHEMICAL INDUSTRY; ENZYMES; FATTY ACIDS; FORECASTING; GERMANY; NETHERLANDS; OLIGOSACCHARIDES; SOLVENTS; STEROIDS; SWITZERLAND;

EID: 0035843170     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35051736     Document Type: Review

References (94)

1. Industrial scale production and application of immobilized glucose isomerase
2. Review of biocatalysis in the production of chiral fine chemicals
3. Enzymes in polymer science: An introduction
4. Application of nitrile converting enzymes for the production of useful compounds
5. Chemical versus biochemical conversion: When and how to use biocatalysts
6. Directed evolution of biocatalysts
7. DNA shuffling by random fragmentation and reassembly: In vitro recombination for molecular evolution
8. Enzymology in monophasic organic media
9. Asymmetric transformations catalyzed by enzymes in organic solvents
10. Studying enzyme activity in supercritical fluids
11. Crosslinked enzyme crystals of lipases as catalysts for kinetic resolution of acids and alcohols
12. Enzyme-catalyzed synthesis of sugar-containing monomers and linear polymers
13. Salts dramatically enhance activity of enzymes suspended in organic solvents
14. Optimizing the salt-induced activation of enzymes in organic solvents: Effects of lyophilization time and water content
15. On the salt-induced activation of lyophilized enzymes in organic solvents: Effect of salt kosmotropicity on enzyme activity
16. Effects of crown ethers and sm all amounts of cosolvent on the activity and enantioselectivity of α-chymotrypsin in organic solvents
17. Induction of catalytic activity in proteins by lyophilization in the presence ora transition state analogue
18. Inhibitor-induced enzyme activation in organic solvents
19. Synthesis of water soluble Paclitaxel derivatives by enzymatic acylation
20. Aqueous-like activity of α-chymotrypsin dissolved in nearly anhydrous organic solvents
21. Biocatalytic plastics as active and stable materials for biotransformations
22. Activity and stability of enzymes incorporated into acrylic polymers
23. Biocatalytic solvent-free polymerization to produce high molecular weight polyesters
24. Efficient production of optically active styrene epoxides in two-liquid phase cultures
25. Biosynthesis of synthons in two-liquid phase media
26. Preparative scale production of 3-substituted catechols using a novel monooxygenase from Pseudomonas azelaica HBP1
27. Synthesis of 1,2-epoxyoctane by Pseudomonas oleovorans during growth in a two phase system containing high concentrations of 1-octene
28. Practical approach to high yield enzymatic stereospecific organic synthesis in multiphase systems
29. Pseudomonas oleovorans as a tool in bioconversions of organic substrates: Growth, morphology and conversion characteristics in different two-phase systems
30. Bioconversion of n-octane to octanoic acid by a recombinant Escherichia coli cultured in a two-liquid phase bioreactor
31. Rules for optimization of biocatalysts in organic solvents
32. Whole cell biocatalysis in nonconventional media
33. Microbial conversion of indene to indanol: A key intermediate in the synthesis of Crixivan
34. Developments toward large scale bacterial bioprocesses in the presence of bulk amounts of organic solvents
35. Integrated two-liquid phase bioconversion and productrecovery processes for the oxidation of alkanes: Process design and economic evaluation
36. Towards a biocatalyst for (S)-styrene oxide production: Characterization of the styrene degradation pathway of Pseudomonas sp. strain VLB120
37. Enzymatic oxidation of methyl groups on aromatic heterocycles: A versatile method for the preparation of heteroaromatic carboxylic acids
38. Biocatalysis in the gas phase
39. An integrated process for the production of toxic catechols from toxic phenols based on a designer biocatalyst
40. Preparation of optically active N-benzyl3-hydroxy-pyrrolidine by enzymatic hydroxylation
41. Medium chain length alkane solvent-cell transfer rates in two-liquid phase, Pseudomonas oleovorans cultures
42. Developments toward large-scale bacterial bioprocesses in the presence of bulk amounts of organic solvents
43. Production of enantiopure styrene oxide by recombinant Escherichia coli synthesizing a two-component styrene monooxygenase
44. Engineering of a stable whole-cell biocatalyst capable of (S)-styrene oxide formation for continuous two-liquid-phase applications
45. Application of in sim product-removal techniques to biocatalytic processes
46. Bioconversions of aliphatic compounds by Pseudomonas oleovorans in multiphase bioreactors: Background and economic potential
47. Alkanol removal from the apolar phase ora two-liquid fermentation system. 2. Effect of fermentation medium on distillation
48. Alkanol removal from the apolar phase ora two-liquid fermentation system. 1. Comparison of a less volatile and more volatile in situ extraction solvent for separation of 1-octanol by distillation
49. Optically active amines via lipase-catalyzed methoxyacetylation
50. The development of enzymes for the preparation of chemicals
51. Enzyme product with L-α-aminoacylamidase activity
52. Biocatalytic production of unnatural amino acids
53. DSM gets the biocatalysis bug
54. Preparation and use of enantiomerically pure Cα-tetrasubstituted α-amino acids
55. Enzymic resolution of α,α-disubstituted α-amino acid esters and amides
56. Synthesis of optically pure α-alkylated α-amino acids and a single-step method for enantiomeric excess determination
57. Synthesis of racemic α-amino carboxamides via Lewis acid-mediated reactions of αmethoxyglycinamide derivatives with allylsilanes: Enzymic resolution to optically active α-amino acids
58. Application of enzymes in industrial organic synthesis
59. Biocatalysis and process integration in the synthesis of semisynthetic antibiotics
60. Immobilized Streptomyces clavuligerus NP1 cells for biotransformation of penicillin G into deacetoxycephalosporin G
61. Penicillin acylase in the industrial production of β-lactam antibiotics
62. Enzymatic hydroxylations in industrial application
63. Bioconversion of 2-cyanopyrazine to 5-hydroxypvrazine-2carboxylic acid with Agrobacterium sp. DSM 6336
64. Quantitative structure-activity relationships for the in-vitro antimycobacterial activity for pyrazinoic acid esters
65. Epibatidine: A novel (chloropyridyl) azabicydoheptane with potent analgesic activity from an Ecuadoran poison frog
66. Renewable functionalized pyridines derived from microbial metabolites of the alkaloid (S)-nicotine
67. Preparation of (S)-piperazine-2-carboxylic acid, (R)- piperazine-2-carboxylic acid, and (S)-piperidine-2-carboxylic acid by kinetic resolution of the corresponding racemic carboxamides with stereoselective amidases in whole bacterial cells
68. A direct electrode driven P450 cycle for biocatalysis
69. Biosynthesis and regulation of microbial polyunsaturated fatty acid production
70. Large scale production of UDP-galactose and globotriose by coupling metabolically engineered bacteria
71. Printing proteins as microarrays for high-throughput function determination
72. Combinatorial biocatalysis: A natural approach to drug discovery
73. Biocatalytic combinatorial synthesis
74. Chiral compounds synthesized by biocatalytic reductions
75. Cofactor regeneration in biocatalysis in organic media
76. Cofactor regeneration for enzyme catalysed synthesis
77. Cofactor-bound cross linked enzyme crystals (CLEC) of alcohol dehydrogenase
78. Formate driven, non-enzymatic NAD(P)H regeneration for the alcohol dehydrogenase catalyzed stereoselective reduction of 4-phenylbutanone
79. First synthetic application ora monooxygenase employing indirect electrochemical NADH-regeneration
80. Artificial electron carriers for preparative biocatalytic redox reactions forming reversibly carbon hydrogen bonds with enzymes present in strict or facultative anaerobes
81. In vitro ATP regeneration from polyphosphate and AMP by polyphosphate: AMP phosphotransferase and adenylate kinase from Acinetobacter johnsonii 210A