Reconstructing a missing link in the evolution of a recently diverged phosphotriesterase by active-site loop remodeling

Biochemistry

Volumn 51, Issue 31, 2012, Pages 6047-6055

  Afriat Jurnou, Livnat ^a   Jackson, Colin J ^b   Tawfik, Dan S ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIFUNCTIONAL; ENZYMATIC FUNCTIONS; ENZYME FUNCTIONS; HOMOSERINE; HOMOSERINE LACTONES; LACTONASE; ORGANOPHOSPHATE PESTICIDES; PHOSPHOTRIESTERASES; PHYLOGENETIC ANALYSIS; POINT MUTATIONS; QUORUM-SENSING; SEQUENCE IDENTITY;

BIOCHEMISTRY; CHEMISTRY;

DEGRADATION;

ARYLDIALKYLPHOSPHATASE; GLUCONOLACTONASE; HOMOSERINE; PHOSPHOTRIESTERASE;

ANALYTIC METHOD; ARTICLE; CHEMICAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; LOOP REMODELING; NONHUMAN; PHYLOGENY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORIC TRIESTER HYDROLASES; PHYLOGENY; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 84864645362     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300694t     Document Type: Article

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