Alteration of enzyme specificity by computational loop remodeling and design

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 23, 2009, Pages 9215-9220

  Murphy, Paul M ^a,b   Bolduc, Jill M ^c   Gallaher, Jasmine L ^d   Stoddard, Barry L ^c   Baker, David ^a,d  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Computational protein design; Loop modeling

Indexed keywords

GUANINE DEAMINASE;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; WILD TYPE;

ALGORITHMS; CRYSTALLOGRAPHY, X-RAY; GUANINE DEAMINASE; HUMANS; MODELS, MOLECULAR; PROTEIN ENGINEERING; SUBSTRATE SPECIFICITY; TRIAZINES;

EID: 67249107701     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0811070106     Document Type: Article

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