On the generation of catalytic antibodies by transition state analogues

ChemBioChem

Volumn 4, Issue 4, 2003, Pages 277-285

  Barbany, Montserrat ^a   Gutiérrez de Terán, Hugo ^a   Sanz, Ferran ^a   Villà Freixa, Jordi ^a   Warshel, Arieh ^b  

^a INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Catalytic antibodies; Langevin dipoles; Molecular interaction potentials; Structure activity relationships; Transition states

Indexed keywords

CATALYTIC ANTIBODY; CATALYTIC ANTIBODY 1F7; CHORISMATE MUTASE; ENZYME; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTIBODY DETECTION; ARTICLE; CATALYSIS; CONCEPT FORMATION; DIAGNOSTIC APPROACH ROUTE; DIPOLE; DRUG DESIGN; ELECTRICITY; ENERGY; ENZYME RELEASE; LANGEVIN DIPOLE; MATHEMATICAL ANALYSIS; MOLECULAR INTERACTION; MOLECULAR STABILITY; PHASE TRANSITION; POLARIZATION; PRIORITY JOURNAL; PROBLEM SOLVING; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REACTION ANALYSIS; SURFACE CHARGE; THREE DIMENSIONAL IMAGING; TRANSITION STATE ANALOG;

ANTIBODIES, CATALYTIC; CHEMISTRY, PHYSICAL; DRUG STABILITY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0242515838     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200390048     Document Type: Article

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