Surface sites for engineering allosteric control in proteins

Science

Volumn 322, Issue 5900, 2008, Pages 438-442

  Lee, Jeeyeon ^a   Natarajan, Madhusudan ^b   Nashine, Vishal C ^a   Socolich, Michael ^b   Vo, Tina ^b   Russ, William P ^b   Benkovic, Stephen J ^a   Ranganathan, Rama ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CHIMERIC PROTEIN; DIHYDROFOLATE REDUCTASE; PROTEIN PAS; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

AMINO ACID; CATALYSIS; ENZYME ACTIVITY; PROTEIN; SIGNALING; STATISTICAL ANALYSIS; SURFACE;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; BINDING SITES; CATALYSIS; ESCHERICHIA COLI; FLAVOPROTEINS; KINETICS; LIGANDS; LIGHT; MODELS, MOLECULAR; NADP; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE;

ESCHERICHIA COLI;

EID: 54249105941     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1159052     Document Type: Article

References (37)

1. F. M. Richards, W. A. Lim, Q. Rev. Biophys. 26, 423 (1993).
2. J. Tsai, R. Taylor, C. Chothia, M. Gerstein, J. Mol. Biol. 290, 253 (1999).
3. J. F. Swain, L. M. Gierasch, Curr. Opin. Struct. Biol. 16, 102 (2006).
4. S. J. Benkovic, S. Hammes-Schiffer, Science 301, 1196 (2003).
5. S. Hammes-Schiffer, S. J. Benkovic, Annu. Rev. Biochem. 75, 519 (2006).
6. K. Henzler-Wildman, D. Kern, Nature 450, 964 (2007).
7. I. Luque, S. A. Leavitt, E. Freire, Annu. Rev. Biophys. Biomol. Struct. 31, 235 (2002).
8. S. W. Lockless, R. Ranganathan, Science 286, 295 (1999).
9. G. M. Suel, S. W. Lockless, M. A. Wall, R. Ranganathan, Nat. Struct. Biol. 10, 59 (2003).
10. A. D. Ferguson et al., Proc. Natl. Acad. Sci. U.S.A. 104, 513 (2007).
11. M. E. Hatley, S. W. Lockless, S. K. Gibson, A. G. Gilman, R. Ranganathan, Proc. Natl. Acad. Sci. U.S.A. 100, 14445 (2003).
12. A. I. Shulman, C. Larson, D. J. Mangelsdorf, R. Ranganathan, Cell 116, 417 (2004).
13. S. M. Garrard et al., EMBO J. 22, 1125 (2003).
14. F. C. Peterson, R. R. Penkert, B. F. Volkman, K. E. Prehoda, Mol. Cell 13, 665 (2004).
15. M. Salomon et al., Proc. Natl. Acad. Sci. U.S.A. 98, 12357 (2001).
16. B. L. Taylor, I. B. Zhulin, Microbiol. Mol. Biol. Rev. 63, 479 (1999).
17. Y. Z. Gu, J. B. Hogenesch, C. A. Bradfield, Annu. Rev. Pharmacol. Toxicol. 40, 519 (2000).
18. A. S. Halavaty, K. Moffat, Biochemistry 46, 14001 (2007).
19. S. M. Harper, L. C. Neil, K. H. Gardner, Science 301, 1541 (2003).
20. M. A. Cusanovich, T. E. Meyer, Biochemistry 42, 4759 (2003).
21. P. J. Erbel, P. B. Card, O. Karakuzu, R. K. Bruick, K. H. Gardner, Proc. Natl. Acad. Sci. U.S.A. 100, 15504 (2003).
22. R. Brudler et al., J. Mol. Biol. 363, 148 (2006).
23. P. T. Rajagopalan, S. J. Benkovic, Chem. Rec. 2, 24 (2002).
24. M. R. Sawaya, J. Kraut, Biochemistry 36, 586 (1997).
25. C. E. Cameron, S. J. Benkovic, Biochemistry 36, 15792 (1997).
26. See supporting material on Science Online.
27. M. C. Saraf, A. R. Horswill, S. J. Benkovic, C. D. Maranas, Proc. Natl. Acad. Sci. U.S.A. 101, 4142 (2004).
28. J. M. Christie, M. Salomon, K. Nozue, M. Wada, W. R. Briggs, Proc. Natl. Acad. Sci. U.S.A. 96, 8779 (1999).
29. M. Salomon, J. M. Christie, E. Knieb, U. Lempert, W. R. Briggs, Biochemistry 39, 9401 (2000).
30. J. M. Christie, T. E. Swartz, R. A. Bogomolni, W. R. Briggs, Plant J. 32, 205 (2002).
31. S. M. Harper, J. M. Christie, K. H. Gardner, Biochemistry 43, 16184 (2004).
32. X. Yao, M. K. Rosen, K. H. Gardner, Nat. Chem. Biol. 4, 491 (2008).
33. C. A. Fierke, K. A. Johnson, S. J. Benkovic, Biochemistry 26, 4085 (1987).
34. J. T. Chen, K. Taira, C. P. Tu, S. J. Benkovic, Biochemistry 26, 4093 (1987).
35. D. M. Epstein, S. J. Benkovic, P. E. Wright, Biochemistry 34, 11037 (1995).
36. J. Kuriyan, D. Eisenberg, Nature 450, 983 (2007).
37. We thank members of the Ranganathan and Benkovic labs for discussions, M. Rosen and K. H. Gardner for discussions and sharing of unpublished data and materials, and J. Wang for solvent accessibility calculations. Supported by the Robert A. Welch foundation (R.R.) and a grant from the Defense Advanced Research Projects Agency (R.R. and S.J.B.).