Kemp elimination catalysts by computational enzyme design

Nature

Volumn 453, Issue 7192, 2008, Pages 190-195

  Röthlisberger, Daniela ^a   Khersonsky, Olga ^c   Wollacott, Andrew M ^a   Jiang, Lin ^a,b   DeChancie, Jason ^d   Betker, Jamie ^b   Gallaher, Jasmine L ^b   Althoff, Eric A ^a   Zanghellini, Alexandre ^a,b   Dym, Orly ^c   Albeck, Shira ^c   Houk, Kendall N ^d   Tawfik, Dan S ^c   Baker, David ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOENGINEERING; CATALYSIS; COMPUTER AIDED DESIGN; CRYSTAL STRUCTURE; ENZYME ACTIVITY; MUTATION; PROTEOMICS;

ARTICLE; CATALYSIS; CATALYST; CHEMICAL REACTION; COMPUTATIONAL ENZYME DESIGN; CRYSTAL STRUCTURE; KEMP ELIMINATION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN MOTIF; PROTON TRANSPORT;

EID: 43449098518     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06879     Document Type: Article

References (34)