Enhancing activity and controlling stereoselectivity in a designed PLP-dependent aldolase

Angewandte Chemie - International Edition

Volumn 46, Issue 24, 2007, Pages 4468-4470

  Toscano, Miguel D ^a   Müller, Manuel M ^a   Hilvert, Donald ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Aldolases; Amino acids; Biocatalysis; Rational design; Stereoselectivity

Indexed keywords

AMINO ACIDS; ENZYMES; MUTAGENESIS; PHOSPHATES;

ALDOLASE; CLEAVAGE; ENHANCING ACTIVITY; PHENYLSERINES; RATIONAL DESIGN;

STEREOSELECTIVITY;

BACTERIAL PROTEIN; LYASE; PYRIDOXAL 5 PHOSPHATE;

ARTICLE; BINDING SITE; CHEMISTRY; GENETICS; KINETICS; METABOLISM; METHODOLOGY; PROTEIN ENGINEERING; STEREOISOMERISM;

ALDEHYDE-LYASES; BACTERIAL PROTEINS; BINDING SITES; KINETICS; PROTEIN ENGINEERING; PYRIDOXAL PHOSPHATE; STEREOISOMERISM;

EID: 34250782571     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200700710     Document Type: Article

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