Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 34, 2009, Pages 14271-14275

  Schwans, Jason P ^a   Kraut, Daniel A ^a   Herschlag, Daniel ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

3 cyclohexen 1 one; Enzymatic catalysis; Intrinsic binding energy

Indexed keywords

STEROID; STEROID DELTA ISOMERASE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; ENZYME BINDING; ENZYME SUBSTRATE; MOLECULAR INTERACTION; PRIORITY JOURNAL;

BACTERIAL PROTEINS; CATALYSIS; CATALYTIC DOMAIN; CYCLOHEXENES; HYDROCARBONS, CYCLIC; KETOSTEROIDS; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PSEUDOMONAS PUTIDA; STEROID ISOMERASES; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 70149104037     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0901032106     Document Type: Article

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