The depth of chemical time and the power of enzymes as catalysts

Accounts of Chemical Research

Volumn 34, Issue 12, 2001, Pages 938-945

  Wolfenden, R ^a   Snider, M J ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; WATER;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL BOND; CHEMICAL REACTION KINETICS; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; KINETICS; MICHAELIS CONSTANT; MOLECULAR INTERACTION; PRODUCTIVITY; THERMODYNAMICS; TIME; REVIEW;

CATALYSIS; ENZYMES; KINETICS; THERMODYNAMICS; TIME FACTORS;

EID: 0035543093     PISSN: 00014842     EISSN: None     Source Type: Journal    
DOI: 10.1021/ar000058i     Document Type: Article

References (58)

1. Application of the theory of diffusion-controlled reactions to enzyme kinetics
2. Transition state stabilization by deaminases: Rates of nonenzymatic hydrolysis of adenosine and cytidine
3. Transition state analogs for enzyme catalysis
4. Analog approaches to the structure of the transition state in enzyme reactions
5. Enzymic catalysis and transition-state theory
6. Binding energy and catalysis: The implications for transition-state analogs and catalytic antibodies
7. Enzymatic transition states and transition state analog design
8. The structural basis of ribosome activity in peptide bond synthesis
9. Measurement of very slow reaction rates; decarboxylation of alanine
10. Hydrolysis of a peptide bond in water
11. Direct measurement of the uncatalyzed rate of hydrolysis of a peptide bond
12. On the observation of the course of chemical change
13. Spontaneous hydrolysis of glycosides
14. Rates of uncatalyzed peptide bond hydrolysis in neutral solution and the transition state affinities of proteases
15. Diketopiperazine formation during investigations of amino acid racemization in dipeptides
16. Limits to catalysis by ribonuclease A
17. Spontaneous hydrolysis of ionized phosphate monoesters and diesters and the proficiencies of phosphatases and phosphodiesterases as catalysts
18. Mechanism in carbohydrate chemistry
19. Transition state stabilization and enzyme catalysis. Kinetic and molecular orbital studies of the rearrangement of chorismate to prephenate
20. The uncatalyzed rate of enolization of dihydroxyacetone phosphate and of glyceraldehyde 3-phosphate in neutral aqueous solution. The quantitative assessment of an enzyme catalyst
21. Enzymatic hydration of an olefin: The burden borne by fumarase
22. Mandelate racemase in pieces: Effective concentrations of enzyme functional groups in the transition state
23. A proficient enzyme
24. The kinetics and rapid thermochemistry of carbonic acid
25. The rate of spontaneous decarboxylation of amino acids
26. Critical review of hydrolysis of organic compounds in water under environmental conditions
27. Temperature effects in enzyme kinetics
28. The temperature dependence of enzyme rate enhancements
29. Temperature effects on the catalytic efficiency, rate enhancement and transition state affinity of cytidine deaminase, and the thermodynamic consequences for catalysis of removing a substrate "anchor"
30. Contributions of a single hydroxyl group to transition-state discrimination by adenosine deaminase: Evidence for and "entropy trap" mechanism
31. Energetics of the uncatalyzed and glutamate dehydrogenase catalyzed imino acid-amino acid interconversion
32. Electrostatic origin of the catalytic power of enzymes and the role of preorganized active sites
33. The form of 2-phosphoglycolate bound by triosephosphate isomerase
34. Extreme state of ionization of benzylsucinate bound by carboxypeptidase A
35. Cytidine deaminase complexed to 3-deazacytidine: A "valence buffer" in zinc enzyme catalysis
36. Cytidine deaminase. The 2.3 a crystal structure of an enzyme: Transition-state analog complex
37. The structure of the cytidine deaminase-product complex provides evidence for efficient proton transfer and ground-state destabilization
38. Site-bound water and the shortcomings of a less-than-perfect transition state analogue inhibitor
39. Complementary truncations of a hydrogen bond to ribose involved in transition state stabilization by cytidine deaminase
40. Enzyme-substrate complexes of adenosine and cytidine deaminases: Absence of accumulation of water adducts
41. On the attribution and additivity of binding energies
42. Effect of geminal substitution ring size and rotamer distribution on intramolecular nucleophilic catalysis of the hydrolysis of monophenyl esters of dibasic acids
43. Effective molarities for intramolecular reactions
44. Efficiency of proton-transfer catalysis in models and enzymes
45. Exploring the limits of efficiency of proton-transfer catalysis in models and enzymes
46. Substrate connectivity effects in the transition state for cytidine deaminase
47. Contribution of enzyme-phosphoribosyl contacts to catalysis by orotidine 5′phosphate decarboxylase
48. A transition state in pieces: Major contributions of entropic effects to ligand binding by adenosine deaminase
49. Mandelate racemase in pieces: Effective concentrations of enzyme functional groups in the transition state
50. Major contribution of a carboxymethyl group to transition state stabilization by cytidine deaminase: Mutation and rescue
51. Dissecting a charged network at the active site of orotidine 5′-phosphate decarboxylase
52. Entropic contributions to rate accelerations in enzymes and intramolecular reactions and the chelate effect
53. Thermodynamics of chelation. I. The statistical factor in chelate ring formation
54. Enthalpic domination of the chelate effect in cyclodextrin dimers
55. Physical inorganic chemistry