Enzyme millisecond conformational dynamics do not catalyze the chemical step

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 41, 2009, Pages 17359-17364

  Pisliakov, Andrei V ^a,b   Cao, Jie ^a   Kamerlin, Shina C L ^a   Warshel, Arieh ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b RIKEN   (Japan)

Author keywords

Adenylate kinase; Coarse grained model; Enzyme catalysis; Renormalization; Simplified model

Indexed keywords

ENZYME;

ARTICLE; CATALYSIS; ENERGY TRANSFER; ENZYME CONFORMATION; ENZYME MECHANISM; PRIORITY JOURNAL; SIMULATION;

ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; CALORIMETRY; CATALYSIS; COMPUTER SIMULATION; ENERGY TRANSFER; ENZYMES; KINETICS; LIGANDS; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS;

EID: 70350453758     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909150106     Document Type: Article

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