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Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 7, 2001, Pages 3778-3783

Computational method to reduce the search space for directed protein evolution

(4) Voigt, Christopher A a Mayo, Stephen L a Arnold, Frances H b Wang, Zhen Gang b

a CALIFORNIA INSTITUTE OF TECHNOLOGY (United States)

b California Institute of Technology (United States)

Author keywords

Combinatorial optimization; Computational protein design; In vitro directed evolution; Mean field theory; Protein tolerance

Indexed keywords

AMINO ACID; LYSOZYME; PROTEIN; SUBTILISIN;

AMINO ACID SUBSTITUTION; ARTICLE; CALCULATION; COMBINATORIAL CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; ENTROPY; GENE MUTATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN STABILITY;

BACTERIOPHAGE T4; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DIRECTED MOLECULAR EVOLUTION; MURAMIDASE; MUTAGENESIS; PROTEIN CONFORMATION; SUBTILISINS;

EID: 0035957360 PISSN: 00278424 EISSN: None Source Type: Journal
DOI: 10.1073/pnas.051614498 Document Type: Article

Times cited : (154)

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