Evolution of hormone-receptor complexity by molecular exploitation

Science

Volumn 312, Issue 5770, 2006, Pages 97-101

  Bridgham, Jamie T ^a   Carroll, Sean M ^a   Thornton, Joseph W ^a  

^a UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTATIONAL COMPLEXITY; GENES; OPTIMIZATION;

ANCIENT LIGANDS; DARWINIAN PROCESS; GENE RESURRECTION; RECEPTOR SPECIFICITY;

GENETIC ENGINEERING;

ALDOSTERONE; AMINO ACID; LIGAND; LUCIFERASE; MINERALOCORTICOID RECEPTOR;

COMPLEXITY; EVOLUTION; HORMONE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANCESTRAL GENE RESURRECTION; ARTICLE; BAYES THEOREM; GENE DUPLICATION; GENETIC ANALYSIS; HORMONE RECEPTOR INTERACTION; MAXIMUM LIKELIHOOD METHOD; MOLECULAR EVOLUTION; MOLECULAR INTERACTION; MONTE CARLO METHOD; NATURAL SELECTION; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROBABILITY; RECEPTOR AFFINITY; REPORTER GENE; SEQUENCE ANALYSIS; THEORY;

ALDOSTERONE; AMINO ACID SUBSTITUTION; ANIMALS; BAYES THEOREM; BINDING SITES; DESOXYCORTICOSTERONE; EVOLUTION, MOLECULAR; GENE DUPLICATION; HAGFISHES; HYDROCORTISONE; LAMPREYS; LIGANDS; MUTATION; PERCIFORMES; PHYLOGENY; RATS; RECEPTORS, ALDOSTERONE; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; RECEPTORS, STEROID; SKATES (FISH);

EID: 33645691679     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1123348     Document Type: Article

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