Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer

Journal of the American Chemical Society

Volumn 134, Issue 1, 2012, Pages 375-385

  Der, Bryan S ^a   MacHius, Mischa ^a   Miley, Michael J ^a   Mills, Jeffrey L ^b   Szyperski, Thomas ^b   Kuhlman, Brian ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC RESEARCH; BINDING MODES; COMPUTATIONAL MODEL; DISSOCIATION CONSTANT; HIGH AFFINITY; HOMODIMERS; METAL BINDING SITES; METAL INTERFACE; POINT MUTATIONS; PROTEIN MONOMERS; PROTEIN-PROTEIN INTERACTIONS; RATIONAL DESIGN; TARGET ID; TARGET INTERFACE;

AMINO ACIDS; BINDING ENERGY; BINDING SITES; COMPUTATIONAL METHODS; CRYSTAL STRUCTURE; DIMERS; DISSOCIATION; METALS; PROTEINS;

ZINC;

DIMER; GLUTAMIC ACID; HISTIDINE; HOMODIMER; MONOMER; ZINC;

ARTICLE; BINDING AFFINITY; BINDING SITE; BIOTECHNOLOGY; CRYSTAL STRUCTURE; MEDICINE; METAL BINDING; POINT MUTATION; PROTEIN PROTEIN INTERACTION; SENSITIVITY AND SPECIFICITY;

DRUG DESIGN; MODELS, MOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEINS; ZINC;

EID: 84855685292     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja208015j     Document Type: Article

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