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Volumn 4, Issue 4, 2008, Pages 322-353

Nanocarriers for gene delivery - Polymer structure, targeting ligands and controlled-release devices

Author keywords

Controlled release; Gene delivery; Nanoparticles; Polymer; Targeting

Indexed keywords

AMINO ESTERS; BIOCOMPATIBLE MATERIALS; BIOLOGICAL PROPERTIES; CATIONIC COMPLEXES; CONTROLLED RELEASE; DNA DEGRADATION; GENE DELIVERY; GENE DELIVERY SYSTEMS; GENE THERAPY; GENETIC MATERIALS; IMMUNOGENICITY; IN-SITU FORMING; INSERTIONAL MUTAGENESIS; NANOCARRIERS; NONVIRAL; NONVIRAL VECTORS; POLY LACTIDE-CO-GLYCOLIDE; POLYCATIONS; POLYETHYLENIMINES; POLYMER STRUCTURE; POLYPLEXES; REDUCED TOXICITY; SAFETY CONCERNS; SLOW RELEASE; TARGETING; THERAPEUTIC USE; VIRAL VECTORS;

EID: 65749120721     PISSN: 15734137     EISSN: None     Source Type: Journal    
DOI: 10.2174/157341308786306062     Document Type: Review
Times cited : (38)

References (381)
  • 1
    • 0032993342 scopus 로고    scopus 로고
    • Improving plant drought, salt, and freezing tolerance by gene transfer of a single stress-inducible transcription factor
    • Kasuga, M.; Liu, Q.; Miura, S.; Yamaguchi-Shinozaki, K.; Shinozaki, K. Improving plant drought, salt, and freezing tolerance by gene transfer of a single stress-inducible transcription factor. Nat. Biotechnol., 1999, 17(3), 287.
    • (1999) Nat. Biotechnol , vol.17 , Issue.3 , pp. 287
    • Kasuga, M.1    Liu, Q.2    Miura, S.3    Yamaguchi-Shinozaki, K.4    Shinozaki, K.5
  • 2
    • 0025840490 scopus 로고
    • Gene transfer with subsequent removal of the selection gene from the host genome
    • Dale, E.C.; Ow, D.W. Gene transfer with subsequent removal of the selection gene from the host genome. Proc. Natl. Acad. Sci. USA., 1991, 88 (23), 10558.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , Issue.23 , pp. 10558
    • Dale, E.C.1    Ow, D.W.2
  • 4
    • 0032580348 scopus 로고    scopus 로고
    • Human gene therapy
    • Anderson, W.F. Human gene therapy. Nature, 1998, 392 (6679 Suppl), 25.
    • (1998) Nature , vol.392 , Issue.6679 SUPPL. , pp. 25
    • Anderson, W.F.1
  • 5
    • 0032605317 scopus 로고    scopus 로고
    • Pharmaceutical perspectives of nonviral gene therapy
    • Mahato, R.I.; Smith, L.C.; Rolland, A. Pharmaceutical perspectives of nonviral gene therapy. Adv. Genet., 1999, 41, 95.
    • (1999) Adv. Genet , vol.41 , pp. 95
    • Mahato, R.I.1    Smith, L.C.2    Rolland, A.3
  • 7
    • 0025949812 scopus 로고
    • Adenovirus enhancement of transferrin-polylysine-mediated gene delivery
    • Curiel, D.T.; Agarwal, S.; Wagner, E.; Cotten, M. Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proc. Natl. Acad. Sci. USA., 1991, 88 (19), 8850.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , Issue.19 , pp. 8850
    • Curiel, D.T.1    Agarwal, S.2    Wagner, E.3    Cotten, M.4
  • 8
    • 0033533669 scopus 로고    scopus 로고
    • Virus treatment questioned after gene therapy death
    • Lehrman, S. Virus treatment questioned after gene therapy death. Nature, 1999, 401 (6753), 517.
    • (1999) Nature , vol.401 , Issue.6753 , pp. 517
    • Lehrman, S.1
  • 9
    • 0142089747 scopus 로고    scopus 로고
    • Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
    • Raper, S.E.; Chirmule, N.; Lee, F.S.; Wivel, N.A.; Bagg, A.; Gao, G.P.; Wilson, J.M.; Batshaw, M.L. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol. Genet. Metab., 2003, 80 (1-2), 148.
    • (2003) Mol. Genet. Metab , vol.80 , Issue.1-2 , pp. 148
    • Raper, S.E.1    Chirmule, N.2    Lee, F.S.3    Wivel, N.A.4    Bagg, A.5    Gao, G.P.6    Wilson, J.M.7    Batshaw, M.L.8
  • 11
    • 0142084745 scopus 로고    scopus 로고
    • Hacein-Bey-Abina, S.; Von Kalle, C.; Schmidt, M.; McCormack, M.P.; Wulffraat, N.; Leboulch, P.; Lim, A.; Osborne, C.S.; Pawliuk, R.; Morillon, E.; Sorensen, R.; Forster, A.; Fraser, P.; Cohen, J.I.; de Saint Basile, G.; Alexander, I.; Wintergerst, U.; Frebourg, T.; Aurias, A.; Stoppa-Lyonnet, D.; Romana, S.; Radford-Weiss, I.; Gross, F.; Valensi, F.; Delabesse, E.; Macintyre, E.; Sigaux, F.; Soulier, J.; Leiva, L.E.; Wissler, M.; Prinz, C.; Rabbitts, T.H.; Le Deist, F.; Fischer, A.; Cavazzana-Calvo, M. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science, 2003, 302 (5644), 415.
    • Hacein-Bey-Abina, S.; Von Kalle, C.; Schmidt, M.; McCormack, M.P.; Wulffraat, N.; Leboulch, P.; Lim, A.; Osborne, C.S.; Pawliuk, R.; Morillon, E.; Sorensen, R.; Forster, A.; Fraser, P.; Cohen, J.I.; de Saint Basile, G.; Alexander, I.; Wintergerst, U.; Frebourg, T.; Aurias, A.; Stoppa-Lyonnet, D.; Romana, S.; Radford-Weiss, I.; Gross, F.; Valensi, F.; Delabesse, E.; Macintyre, E.; Sigaux, F.; Soulier, J.; Leiva, L.E.; Wissler, M.; Prinz, C.; Rabbitts, T.H.; Le Deist, F.; Fischer, A.; Cavazzana-Calvo, M. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science, 2003, 302 (5644), 415.
  • 12
    • 0034997403 scopus 로고    scopus 로고
    • Non-viral vectors in cancer gene therapy: Principles and progress
    • Schatzlein, A.G. Non-viral vectors in cancer gene therapy: principles and progress. Anticancer Drugs, 2001, 12 (4), 275.
    • (2001) Anticancer Drugs , vol.12 , Issue.4 , pp. 275
    • Schatzlein, A.G.1
  • 13
  • 14
    • 0032959729 scopus 로고    scopus 로고
    • Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery
    • Dash, P.R.; Read, M.L.; Barrett, L.B.; Wolfert, M.A.; Seymour, L.W. Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery. Gene Ther., 1999, 6 (4), 643.
    • (1999) Gene Ther , vol.6 , Issue.4 , pp. 643
    • Dash, P.R.1    Read, M.L.2    Barrett, L.B.3    Wolfert, M.A.4    Seymour, L.W.5
  • 18
    • 0030709447 scopus 로고    scopus 로고
    • Expression of naked plasmid DNA injected into the afferent and efferent vessels of rodent and dog livers
    • Zhang, G.; Vargo, D.; Budker, V.; Armstrong, N.; Knechtle, S.; Wolff, J.A. Expression of naked plasmid DNA injected into the afferent and efferent vessels of rodent and dog livers. Hum. Gene Ther., 1997, 8 (15), 1763.
    • (1997) Hum. Gene Ther , vol.8 , Issue.15 , pp. 1763
    • Zhang, G.1    Vargo, D.2    Budker, V.3    Armstrong, N.4    Knechtle, S.5    Wolff, J.A.6
  • 20
    • 0027255414 scopus 로고
    • Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA
    • Vile, R.G.; Hart, I.R. Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA. Cancer Res., 1993, 53 (17), 3860.
    • (1993) Cancer Res , vol.53 , Issue.17 , pp. 3860
    • Vile, R.G.1    Hart, I.R.2
  • 21
    • 0029891426 scopus 로고    scopus 로고
    • Direct gene transfer to mouse melanoma by intratumor injection of free DNA
    • Yang, J.P.; Huang, L. Direct gene transfer to mouse melanoma by intratumor injection of free DNA. Gene Ther., 1996, 3 (6), 542.
    • (1996) Gene Ther , vol.3 , Issue.6 , pp. 542
    • Yang, J.P.1    Huang, L.2
  • 23
    • 2442761730 scopus 로고    scopus 로고
    • Role of endogenous endonucleases and tissue site in transfection and CpG-mediated immune activation after naked DNA injection
    • Barry, M.E.; Pinto-Gonzalez, D.; Orson, F.M.; McKenzie, G.J.; Petry, G.R.; Barry, M.A. Role of endogenous endonucleases and tissue site in transfection and CpG-mediated immune activation after naked DNA injection. Hum. Gene Ther., 1999, 10 (15), 2461.
    • (1999) Hum. Gene Ther , vol.10 , Issue.15 , pp. 2461
    • Barry, M.E.1    Pinto-Gonzalez, D.2    Orson, F.M.3    McKenzie, G.J.4    Petry, G.R.5    Barry, M.A.6
  • 24
    • 0032805251 scopus 로고    scopus 로고
    • Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
    • Liu, F.; Song, Y.; Liu, D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther., 1999, 6 (7), 1258.
    • (1999) Gene Ther , vol.6 , Issue.7 , pp. 1258
    • Liu, F.1    Song, Y.2    Liu, D.3
  • 25
    • 65749086977 scopus 로고    scopus 로고
    • Clinical Study with Hydrodynamic Gene Delivery into Hepatocytes in Humans. ASGT, 9th Annual Meeting
    • Habib, N. Clinical Study with Hydrodynamic Gene Delivery into Hepatocytes in Humans. ASGT, 9th Annual Meeting, Executive Summaries, 2006, 36.
    • (2006) Executive Summaries , pp. 36
    • Habib, N.1
  • 27
    • 0031753867 scopus 로고    scopus 로고
    • Gene transfer into muscle by electroporation in vivo
    • Aihara, H.; Miyazaki, J. Gene transfer into muscle by electroporation in vivo. Nat. Biotechnol., 1998, 16 (9), 867.
    • (1998) Nat. Biotechnol , vol.16 , Issue.9 , pp. 867
    • Aihara, H.1    Miyazaki, J.2
  • 30
    • 13644257020 scopus 로고    scopus 로고
    • Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer
    • Huth, S.; Lausier, J.; Gersting, S.W.; Rudolph, C.; Plank, C.; Welsch, U.; Rosenecker, J. Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer. J. Gene Med., 2004, 6 (8), 923.
    • (2004) J. Gene Med , vol.6 , Issue.8 , pp. 923
    • Huth, S.1    Lausier, J.2    Gersting, S.W.3    Rudolph, C.4    Plank, C.5    Welsch, U.6    Rosenecker, J.7
  • 31
    • 0023447252 scopus 로고    scopus 로고
    • Felgner, P.L.; Gadek, T.R.; Holm, M.; Roman, R.; Chan, H.W.; Wenz, M.; Northrop, J.P.; Ringold, G.M.; Danielsen, M. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. USA, 1987, 84 (21), 7413.
    • Felgner, P.L.; Gadek, T.R.; Holm, M.; Roman, R.; Chan, H.W.; Wenz, M.; Northrop, J.P.; Ringold, G.M.; Danielsen, M. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. USA, 1987, 84 (21), 7413.
  • 34
    • 0014441009 scopus 로고
    • Studies on phosphatidylcholine vesicles. Formation and physical characteristics
    • Huang, C. Studies on phosphatidylcholine vesicles. Formation and physical characteristics. Biochemistry, 1969, 8 (1), 344.
    • (1969) Biochemistry , vol.8 , Issue.1 , pp. 344
    • Huang, C.1
  • 35
    • 0023029847 scopus 로고
    • Preparation of liposomes via detergent removal from mixed micelles by dilution. The effect of bilayer composition and process parameters on liposome characteristics
    • Jiskoot, W.; Teerlink, T.; Beuvery, E.C.; Crommelin, D.J. Preparation of liposomes via detergent removal from mixed micelles by dilution. The effect of bilayer composition and process parameters on liposome characteristics. Pharm. Weekbl. Sci., 1986, 8 (5), 259.
    • (1986) Pharm. Weekbl. Sci , vol.8 , Issue.5 , pp. 259
    • Jiskoot, W.1    Teerlink, T.2    Beuvery, E.C.3    Crommelin, D.J.4
  • 36
    • 0023047980 scopus 로고
    • Vesicles of variable sizes produced by a rapid extrusion procedure
    • Mayer, L.D.; Hope, M.J.; Cullis, P.R. Vesicles of variable sizes produced by a rapid extrusion procedure. Biochim. Biophys. Acta, 1986, 858 (1), 161.
    • (1986) Biochim. Biophys. Acta , vol.858 , Issue.1 , pp. 161
    • Mayer, L.D.1    Hope, M.J.2    Cullis, P.R.3
  • 37
    • 0036877043 scopus 로고    scopus 로고
    • Cationic lipid-DNA complexes-lipoplexes-for gene transfer and therapy
    • Zhdanov, R.I.; Podobed, O.V.; Vlassov, V.V. Cationic lipid-DNA complexes-lipoplexes-for gene transfer and therapy. Bioelectrochemistry, 2002, 58 (1), 53.
    • (2002) Bioelectrochemistry , vol.58 , Issue.1 , pp. 53
    • Zhdanov, R.I.1    Podobed, O.V.2    Vlassov, V.V.3
  • 38
    • 0034103894 scopus 로고    scopus 로고
    • Stabilized plasmid-lipid particles: Pharmacokinetics and plasmid delivery to distal tumors following intravenous injection
    • Monck, M.A.; Mori, A.; Lee, D.; Tam, P.; Wheeler, J.J.; Cullis, P.R.; Scherrer, P. Stabilized plasmid-lipid particles: pharmacokinetics and plasmid delivery to distal tumors following intravenous injection. J. Drug Target., 2000, 7 (6), 439.
    • (2000) J. Drug Target , vol.7 , Issue.6 , pp. 439
    • Monck, M.A.1    Mori, A.2    Lee, D.3    Tam, P.4    Wheeler, J.J.5    Cullis, P.R.6    Scherrer, P.7
  • 39
    • 0031036238 scopus 로고    scopus 로고
    • Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes
    • Radler, J.O.; Koltover, I.; Salditt, T.; Safinya, C.R. Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes. Science, 1997, 275 (5301), 810.
    • (1997) Science , vol.275 , Issue.5301 , pp. 810
    • Radler, J.O.1    Koltover, I.2    Salditt, T.3    Safinya, C.R.4
  • 40
    • 0028072689 scopus 로고
    • New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy
    • Sternberg, B.; Sorgi, F.L.; Huang, L. New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy. FEBS Lett., 1994, 356 (2-3), 361.
    • (1994) FEBS Lett , vol.356 , Issue.2-3 , pp. 361
    • Sternberg, B.1    Sorgi, F.L.2    Huang, L.3
  • 42
    • 0030668116 scopus 로고    scopus 로고
    • Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration
    • Song, Y.K.; Liu, F.; Chu, S.; Liu, D. Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration. Hum. Gene Ther., 1997, 8 (13), 1585.
    • (1997) Hum. Gene Ther , vol.8 , Issue.13 , pp. 1585
    • Song, Y.K.1    Liu, F.2    Chu, S.3    Liu, D.4
  • 44
    • 0037442870 scopus 로고    scopus 로고
    • Cationic liposome-mediated gene delivery: Biophysical study and mechanism of internalization
    • Almofti, M.R.; Harashima, H.; Shinohara, Y.; Almofti, A.; Baba, Y.; Kiwada, H. Cationic liposome-mediated gene delivery: biophysical study and mechanism of internalization. Arch. Biochem. Biophys., 2003, 410 (2), 246.
    • (2003) Arch. Biochem. Biophys , vol.410 , Issue.2 , pp. 246
    • Almofti, M.R.1    Harashima, H.2    Shinohara, Y.3    Almofti, A.4    Baba, Y.5    Kiwada, H.6
  • 45
    • 0029067792 scopus 로고
    • The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer
    • Farhood, H.; Serbina, N.; Huang, L. The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer. Biochim. Biophys. Acta, 1995, 1235 (2), 289.
    • (1995) Biochim. Biophys. Acta , vol.1235 , Issue.2 , pp. 289
    • Farhood, H.1    Serbina, N.2    Huang, L.3
  • 46
    • 0032475867 scopus 로고    scopus 로고
    • Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo
    • Mounkes, L.C.; Zhong, W.; Cipres-Palacin, G.; Heath, T.D.; Debs, R.J. Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo. J. Biol. Chem., 1998, 273 (40), 26164.
    • (1998) J. Biol. Chem , vol.273 , Issue.40 , pp. 26164
    • Mounkes, L.C.1    Zhong, W.2    Cipres-Palacin, G.3    Heath, T.D.4    Debs, R.J.5
  • 47
    • 0029877628 scopus 로고    scopus 로고
    • Converting an alcohol to an amine in a cationic lipid dramatically alters the co-lipid requirement, cellular transfection activity and the ultrastructure of DNA-cytofectin complexes
    • Wheeler, C.J.; Sukhu, L.; Yang, G.; Tsai, Y.; Bustamente, C.; Felgner, P.; Norman, J.; Manthorpe, M. Converting an alcohol to an amine in a cationic lipid dramatically alters the co-lipid requirement, cellular transfection activity and the ultrastructure of DNA-cytofectin complexes. Biochim. Biophys. Acta, 1996, 1280 (1), 1.
    • (1996) Biochim. Biophys. Acta , vol.1280 , Issue.1 , pp. 1
    • Wheeler, C.J.1    Sukhu, L.2    Yang, G.3    Tsai, Y.4    Bustamente, C.5    Felgner, P.6    Norman, J.7    Manthorpe, M.8
  • 48
    • 0028535425 scopus 로고
    • Gene transfer with a series of lipophilic DNA-binding molecules
    • Remy, J.S.; Sirlin, C.; Vierling, P.; Behr, J.P. Gene transfer with a series of lipophilic DNA-binding molecules. Bioconjug. Chem., 1994, 5 (6), 647.
    • (1994) Bioconjug. Chem , vol.5 , Issue.6 , pp. 647
    • Remy, J.S.1    Sirlin, C.2    Vierling, P.3    Behr, J.P.4
  • 49
    • 0034065318 scopus 로고    scopus 로고
    • Development of cationic liposome formulations for intratracheal gene therapy of early lung cancer
    • Zou, Y.; Zong, G.; Ling, Y.H.; Perez-Soler, R. Development of cationic liposome formulations for intratracheal gene therapy of early lung cancer. Cancer Gene Ther., 2000, 7 (5), 683.
    • (2000) Cancer Gene Ther , vol.7 , Issue.5 , pp. 683
    • Zou, Y.1    Zong, G.2    Ling, Y.H.3    Perez-Soler, R.4
  • 51
    • 0035861585 scopus 로고    scopus 로고
    • Phase behavior, DNA ordering, and size instability of cationic lipoplexes. Relevance to optimal transfection activity
    • Simberg, D.; Danino, D.; Talmon, Y.; Minsky, A.; Ferrari, M.E.; Wheeler, C.J.; Barenholz, Y. Phase behavior, DNA ordering, and size instability of cationic lipoplexes. Relevance to optimal transfection activity. J. Biol. Chem., 2001, 276 (50), 47453.
    • (2001) J. Biol. Chem , vol.276 , Issue.50 , pp. 47453
    • Simberg, D.1    Danino, D.2    Talmon, Y.3    Minsky, A.4    Ferrari, M.E.5    Wheeler, C.J.6    Barenholz, Y.7
  • 52
    • 0032543524 scopus 로고    scopus 로고
    • Synthesis and characterization of long chain alkyl acyl carnitine esters. Potentially biodegradable cationic lipids for use in gene delivery
    • Wang, J.; Guo, X.; Xu, Y.; Barron, L.; Szoka, F.C., Jr. Synthesis and characterization of long chain alkyl acyl carnitine esters. Potentially biodegradable cationic lipids for use in gene delivery. J. Med. Chem., 1998, 41(13), 2207.
    • (1998) J. Med. Chem , vol.41 , Issue.13 , pp. 2207
    • Wang, J.1    Guo, X.2    Xu, Y.3    Barron, L.4    Szoka Jr., F.C.5
  • 53
    • 0033166721 scopus 로고    scopus 로고
    • Lipoplex-mediated gene delivery to the lung occurs within 60 minutes of intravenous administration
    • Barron, L.G.; Gagne, L.; Szoka, F.C., Jr. Lipoplex-mediated gene delivery to the lung occurs within 60 minutes of intravenous administration. Hum. Gene Ther., 1999, 10 (10), 1683.
    • (1999) Hum. Gene Ther , vol.10 , Issue.10 , pp. 1683
    • Barron, L.G.1    Gagne, L.2    Szoka Jr., F.C.3
  • 54
    • 0030866645 scopus 로고    scopus 로고
    • In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes
    • Li, S.; Huang, L. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Ther., 1997, 4(9), 891.
    • (1997) Gene Ther , vol.4 , Issue.9 , pp. 891
    • Li, S.1    Huang, L.2
  • 55
    • 0034035445 scopus 로고    scopus 로고
    • Optimization of cationic lipid/DNA complexes for systemic gene transfer to tumor lesions
    • Anwer, K.; Kao, G.; Proctor, B.; Rolland, A.; Sullivan, S. Optimization of cationic lipid/DNA complexes for systemic gene transfer to tumor lesions. J. Drug Target., 2000, 8 (2), 125.
    • (2000) J. Drug Target , vol.8 , Issue.2 , pp. 125
    • Anwer, K.1    Kao, G.2    Proctor, B.3    Rolland, A.4    Sullivan, S.5
  • 58
    • 0034019945 scopus 로고    scopus 로고
    • Cationic polymer based gene delivery systems
    • De Smedt, S.C.; Demeester, J.; Hennink, W.E. Cationic polymer based gene delivery systems. Pharm. Res., 2000, 17 (2), 113.
    • (2000) Pharm. Res , vol.17 , Issue.2 , pp. 113
    • De Smedt, S.C.1    Demeester, J.2    Hennink, W.E.3
  • 60
    • 0028501007 scopus 로고
    • Gene transfer with synthetic cationic amphiphiles: Prospects for gene therapy
    • Behr, J.P. Gene transfer with synthetic cationic amphiphiles: prospects for gene therapy. Bioconjug. Chem., 1994, 5 (5), 382.
    • (1994) Bioconjug. Chem , vol.5 , Issue.5 , pp. 382
    • Behr, J.P.1
  • 61
    • 0038293017 scopus 로고    scopus 로고
    • Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery
    • Akinc, A.; Lynn, D.M.; Anderson, D.G.; Langer, R. Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery. J. Am. Chem. Soc., 2003, 125 (18), 5316.
    • (2003) J. Am. Chem. Soc , vol.125 , Issue.18 , pp. 5316
    • Akinc, A.1    Lynn, D.M.2    Anderson, D.G.3    Langer, R.4
  • 63
    • 0028132679 scopus 로고
    • Ionization of poly(ethylenimine) and poly (allylamine) at various pH's
    • Suh, J.; Paik, H.-J.; Hwang, B.K. Ionization of poly(ethylenimine) and poly (allylamine) at various pH's. Bioorg. Chem., 1994, 22 (3), 318.
    • (1994) Bioorg. Chem , vol.22 , Issue.3 , pp. 318
    • Suh, J.1    Paik, H.-J.2    Hwang, B.K.3
  • 64
    • 0242414440 scopus 로고    scopus 로고
    • Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes
    • Sonawane, N.D.; Szoka, F.C., Jr.; Verkman, A.S. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J. Biol. Chem., 2003, 278 (45), 44826.
    • (2003) J. Biol. Chem , vol.278 , Issue.45 , pp. 44826
    • Sonawane, N.D.1    Szoka Jr., F.C.2    Verkman, A.S.3
  • 65
    • 0030757526 scopus 로고    scopus 로고
    • Nanoscopic structure of DNA condensed for gene delivery
    • Dunlap, D.D.; Maggi, A.; Soria, M.R.; Monaco, L. Nanoscopic structure of DNA condensed for gene delivery. Nucleic Acids Res., 1997, 25 (15), 3095.
    • (1997) Nucleic Acids Res , vol.25 , Issue.15 , pp. 3095
    • Dunlap, D.D.1    Maggi, A.2    Soria, M.R.3    Monaco, L.4
  • 66
    • 0035284549 scopus 로고    scopus 로고
    • Poly(ethylenimine)-mediated gene delivery affects endothelial cell function and viability
    • Godbey, W.T.; Wu, K.K.; Mikos, A.G. Poly(ethylenimine)-mediated gene delivery affects endothelial cell function and viability. Biomaterials, 2001, 22 (5), 471.
    • (2001) Biomaterials , vol.22 , Issue.5 , pp. 471
    • Godbey, W.T.1    Wu, K.K.2    Mikos, A.G.3
  • 67
    • 0346634895 scopus 로고    scopus 로고
    • In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis
    • Fischer, D.; Li, Y.; Ahlemeyer, B.; Krieglstein, J.; Kissel, T. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials, 2003, 24 (7), 1121.
    • (2003) Biomaterials , vol.24 , Issue.7 , pp. 1121
    • Fischer, D.1    Li, Y.2    Ahlemeyer, B.3    Krieglstein, J.4    Kissel, T.5
  • 69
    • 0038004448 scopus 로고    scopus 로고
    • A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: Effect of molecular weight on transfection efficiency and cytotoxicity
    • Fischer, D.; Bieber, T.; Li, Y.; Elsasser, H.P.; Kissel, T. A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm. Res., 1999, 16 (8), 1273.
    • (1999) Pharm. Res , vol.16 , Issue.8 , pp. 1273
    • Fischer, D.1    Bieber, T.2    Li, Y.3    Elsasser, H.P.4    Kissel, T.5
  • 70
    • 17644401347 scopus 로고    scopus 로고
    • Cross-linked small polyethylenimines: While still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo
    • Thomas, M.; Ge, Q.; Lu, J.J.; Chen, J.; Klibanov, A.M. Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo. Pharm. Res., 2005, 22 (3), 373.
    • (2005) Pharm. Res , vol.22 , Issue.3 , pp. 373
    • Thomas, M.1    Ge, Q.2    Lu, J.J.3    Chen, J.4    Klibanov, A.M.5
  • 71
    • 0037409735 scopus 로고    scopus 로고
    • Polyethylene glycol modified polyethylenimine for improved CNS gene transfer: Effects of PEGylation extent
    • Tang, G.P.; Zeng, J.M.; Gao, S.J.; Ma, Y.X.; Shi, L.; Li, Y.; Too, H.P.; Wang, S. Polyethylene glycol modified polyethylenimine for improved CNS gene transfer: effects of PEGylation extent. Biomaterials, 2003, 24(13), 2351.
    • (2003) Biomaterials , vol.24 , Issue.13 , pp. 2351
    • Tang, G.P.1    Zeng, J.M.2    Gao, S.J.3    Ma, Y.X.4    Shi, L.5    Li, Y.6    Too, H.P.7    Wang, S.8
  • 72
    • 0141990620 scopus 로고    scopus 로고
    • Tumor-targeted gene therapy: Strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes
    • Ogris, M.; Walker, G.; Blessing, T.; Kircheis, R.; Wolschek, M.; Wagner, E. Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes. J. Control. Release, 2003, 91(1-2), 173.
    • (2003) J. Control. Release , vol.91 , Issue.1-2 , pp. 173
    • Ogris, M.1    Walker, G.2    Blessing, T.3    Kircheis, R.4    Wolschek, M.5    Wagner, E.6
  • 73
    • 0031720533 scopus 로고    scopus 로고
    • Polyethylenimine-based intravenous delivery of transgenes to mouse lung
    • Goula, D.; Benoist, C.; Mantero, S.; Merlo, G.; Levi, G.; Demeneix, B.A. Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther., 1998, 5(9), 1291.
    • (1998) Gene Ther , vol.5 , Issue.9 , pp. 1291
    • Goula, D.1    Benoist, C.2    Mantero, S.3    Merlo, G.4    Levi, G.5    Demeneix, B.A.6
  • 74
    • 0032938324 scopus 로고    scopus 로고
    • PEGylated DNA/transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery
    • Ogris, M.; Brunner, S.; Schuller, S.; Kircheis, R.; Wagner, E. PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther., 1999, 6(4), 595.
    • (1999) Gene Ther , vol.6 , Issue.4 , pp. 595
    • Ogris, M.1    Brunner, S.2    Schuller, S.3    Kircheis, R.4    Wagner, E.5
  • 75
    • 0029789793 scopus 로고    scopus 로고
    • Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery
    • Plank, C.; Mechtler, K.; Szoka, F.C., Jr.; Wagner, E. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum. Gene Ther., 1996, 7 (12), 1437.
    • (1996) Hum. Gene Ther , vol.7 , Issue.12 , pp. 1437
    • Plank, C.1    Mechtler, K.2    Szoka Jr., F.C.3    Wagner, E.4
  • 76
    • 23844528337 scopus 로고    scopus 로고
    • Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium
    • Rudolph, C.; Schillinger, U.; Ortiz, A.; Plank, C.; Golas, M.M.; Sander, B.; Stark, H.; Rosenecker, J. Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium. Mol. Ther., 2005, 12 (3), 493.
    • (2005) Mol. Ther , vol.12 , Issue.3 , pp. 493
    • Rudolph, C.1    Schillinger, U.2    Ortiz, A.3    Plank, C.4    Golas, M.M.5    Sander, B.6    Stark, H.7    Rosenecker, J.8
  • 77
    • 0035114195 scopus 로고    scopus 로고
    • Pulmonary cytokine responses associated with PEI-DNA aerosol gene therapy
    • Gautam, A.; Densmore, C.L.; Waldrep, J.C. Pulmonary cytokine responses associated with PEI-DNA aerosol gene therapy. Gene Ther., 2001, 8 (3), 254.
    • (2001) Gene Ther , vol.8 , Issue.3 , pp. 254
    • Gautam, A.1    Densmore, C.L.2    Waldrep, J.C.3
  • 79
    • 0023212742 scopus 로고
    • Receptor-mediated in vitro gene transformation by a soluble DNA carrier system
    • Wu, G.Y.; Wu, C.H. Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. J. Biol. Chem., 1987, 262(10), 4429.
    • (1987) J. Biol. Chem , vol.262 , Issue.10 , pp. 4429
    • Wu, G.Y.1    Wu, C.H.2
  • 80
    • 0033573959 scopus 로고    scopus 로고
    • Kwoh, D.Y.; Coffin, C.C.; Lollo, C.P.; Jovenal, J.; Banaszczyk, M.G.; Mullen, P.; Phillips, A.; Amini, A.; Fabrycki, J.; Bartholomew, R.M.; Brostoff, S.W.; Carlo, D.J. Stabilization of poly-L-lysine/DNA polyplexes for in vivo gene delivery to the liver. Biochim. Biophys. Acta, 1999, 1444(2), 171.
    • Kwoh, D.Y.; Coffin, C.C.; Lollo, C.P.; Jovenal, J.; Banaszczyk, M.G.; Mullen, P.; Phillips, A.; Amini, A.; Fabrycki, J.; Bartholomew, R.M.; Brostoff, S.W.; Carlo, D.J. Stabilization of poly-L-lysine/DNA polyplexes for in vivo gene delivery to the liver. Biochim. Biophys. Acta, 1999, 1444(2), 171.
  • 81
    • 0032727028 scopus 로고    scopus 로고
    • Pharmaceutical and biological properties of poly(amino acid)/DNA polyplexes
    • Lucas, P.; Milroy, D.A.; Thomas, B.J.; Moss, S.H.; Pouton, C.W. Pharmaceutical and biological properties of poly(amino acid)/DNA polyplexes. J. Drug Target., 1999, 7(2), 143.
    • (1999) J. Drug Target , vol.7 , Issue.2 , pp. 143
    • Lucas, P.1    Milroy, D.A.2    Thomas, B.J.3    Moss, S.H.4    Pouton, C.W.5
  • 82
    • 0026655684 scopus 로고
    • Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: Toward a synthetic virus-like gene-transfer vehicle
    • Wagner, E.; Plank, C.; Zatloukal, K.; Cotten, M.; Birnstiel, M.L. Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. Proc. Natl. Acad. Sci. USA, 1992, 89(17), 7934.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , Issue.17 , pp. 7934
    • Wagner, E.1    Plank, C.2    Zatloukal, K.3    Cotten, M.4    Birnstiel, M.L.5
  • 83
    • 0032580453 scopus 로고    scopus 로고
    • Polycation-DNA complexes for gene delivery: A comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids
    • Pouton, C.W.; Lucas, P.; Thomas, B.J.; Uduehi, A.N.; Milroy, D.A.; Moss, S.H. Polycation-DNA complexes for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids. J. Control. Release, 1998, 53(1-3), 289.
    • (1998) J. Control. Release , vol.53 , Issue.1-3 , pp. 289
    • Pouton, C.W.1    Lucas, P.2    Thomas, B.J.3    Uduehi, A.N.4    Milroy, D.A.5    Moss, S.H.6
  • 84
    • 0031883336 scopus 로고    scopus 로고
    • Chloroquine and amphipathic peptide helices show synergistic transfection in vitro
    • Wolfert, M.A.; Seymour, L.W. Chloroquine and amphipathic peptide helices show synergistic transfection in vitro. Gene Ther., 1998, 5 (3), 409.
    • (1998) Gene Ther , vol.5 , Issue.3 , pp. 409
    • Wolfert, M.A.1    Seymour, L.W.2
  • 85
    • 0033137012 scopus 로고    scopus 로고
    • Efficient gene transfer by histidylated polylysine/pDNA complexes
    • Midoux, P.; Monsigny, M. Efficient gene transfer by histidylated polylysine/pDNA complexes. Bioconjug. Chem., 1999, 10 (3), 406.
    • (1999) Bioconjug. Chem , vol.10 , Issue.3 , pp. 406
    • Midoux, P.1    Monsigny, M.2
  • 86
    • 0034688198 scopus 로고    scopus 로고
    • Design of imidazole-containing endosomolytic biopolymers for gene delivery
    • Pack, D.W.; Putnam, D.; Langer, R. Design of imidazole-containing endosomolytic biopolymers for gene delivery. Biotechnol. Bioeng., 2000, 67 (2), 217.
    • (2000) Biotechnol. Bioeng , vol.67 , Issue.2 , pp. 217
    • Pack, D.W.1    Putnam, D.2    Langer, R.3
  • 87
    • 0037133097 scopus 로고    scopus 로고
    • PEG grafted polylysine with fusogenic peptide for gene delivery: High transfection efficiency with low cytotoxicity
    • Lee, H.; Jeong, J.H.; Park, T.G. PEG grafted polylysine with fusogenic peptide for gene delivery: high transfection efficiency with low cytotoxicity. J. Control. Release, 2002, 79 (1-3), 283.
    • (2002) J. Control. Release , vol.79 , Issue.1-3 , pp. 283
    • Lee, H.1    Jeong, J.H.2    Park, T.G.3
  • 88
    • 0036730299 scopus 로고    scopus 로고
    • Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate-mediated targeting in vitro and prolonged plasma circulation in vivo
    • Ward, C.M.; Pechar, M.; Oupicky, D.; Ulbrich, K.; Seymour, L.W. Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate-mediated targeting in vitro and prolonged plasma circulation in vivo. J. Gene Med., 2002, 4 (5), 536.
    • (2002) J. Gene Med , vol.4 , Issue.5 , pp. 536
    • Ward, C.M.1    Pechar, M.2    Oupicky, D.3    Ulbrich, K.4    Seymour, L.W.5
  • 89
    • 0037331755 scopus 로고    scopus 로고
    • Ligand-specific targeting of microspheres to phagocytes by surface modification with poly(L-lysine)-grafted poly(ethylene glycol) conjugate
    • Faraasen, S.; Voros, J.; Csucs, G.; Textor, M.; Merkle, H.P.; Walter, E. Ligand-specific targeting of microspheres to phagocytes by surface modification with poly(L-lysine)-grafted poly(ethylene glycol) conjugate. Pharm. Res., 2003, 20 (2), 237.
    • (2003) Pharm. Res , vol.20 , Issue.2 , pp. 237
    • Faraasen, S.1    Voros, J.2    Csucs, G.3    Textor, M.4    Merkle, H.P.5    Walter, E.6
  • 90
    • 0037130553 scopus 로고    scopus 로고
    • Structure-activity relationships of poly(L-lysines): Effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery
    • Mannisto, M.; Vanderkerken, S.; Toncheva, V.; Elomaa, M.; Ruponen, M.; Schacht, E.; Urtti, A. Structure-activity relationships of poly(L-lysines): effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery. J. Control. Release, 2002, 83 (1), 169.
    • (2002) J. Control. Release , vol.83 , Issue.1 , pp. 169
    • Mannisto, M.1    Vanderkerken, S.2    Toncheva, V.3    Elomaa, M.4    Ruponen, M.5    Schacht, E.6    Urtti, A.7
  • 91
    • 0032453959 scopus 로고    scopus 로고
    • Targeted delivery of plasmid DNA to hepatocytes in vivo: Optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(L-lysine) complexes by controlling their physicochemical properties
    • Nishikawa, M.; Takemura, S.; Takakura, Y.; Hashida, M. Targeted delivery of plasmid DNA to hepatocytes in vivo: optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(L-lysine) complexes by controlling their physicochemical properties. J. Pharmacol. Exp. Ther., 1998, 287 (1), 408.
    • (1998) J. Pharmacol. Exp. Ther , vol.287 , Issue.1 , pp. 408
    • Nishikawa, M.1    Takemura, S.2    Takakura, Y.3    Hashida, M.4
  • 92
    • 0033229887 scopus 로고    scopus 로고
    • Polyelectrolyte vectors for gene delivery: Influence of cationic polymer on biophysical properties of complexes formed with DNA
    • Wolfert, M.A.; Dash, P.R.; Nazarova, O.; Oupicky, D.; Seymour, L.W.; Smart, S.; Strohalm, J.; Ulbrich, K. Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA. Bioconjug. Chem., 1999, 10 (6), 993.
    • (1999) Bioconjug. Chem , vol.10 , Issue.6 , pp. 993
    • Wolfert, M.A.1    Dash, P.R.2    Nazarova, O.3    Oupicky, D.4    Seymour, L.W.5    Smart, S.6    Strohalm, J.7    Ulbrich, K.8
  • 93
    • 0033652541 scopus 로고    scopus 로고
    • Preliminary characterization of novel amino acid based polymeric vesicles as gene and drug delivery agents
    • Brown, M.D.; Schatzlein, A.; Brownlie, A.; Jack, V.; Wang, W.; Tetley, L.; Gray, A.I.; Uchegbu, I.F. Preliminary characterization of novel amino acid based polymeric vesicles as gene and drug delivery agents. Bioconjug. Chem., 2000, 11 (6), 880.
    • (2000) Bioconjug. Chem , vol.11 , Issue.6 , pp. 880
    • Brown, M.D.1    Schatzlein, A.2    Brownlie, A.3    Jack, V.4    Wang, W.5    Tetley, L.6    Gray, A.I.7    Uchegbu, I.F.8
  • 94
    • 0029801424 scopus 로고    scopus 로고
    • Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers
    • Wolfert, M.A.; Schacht, E.H.; Toncheva, V.; Ulbrich, K.; Nazarova, O.; Seymour, L.W. Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers. Hum. Gene Ther., 1996, 7 (17), 2123.
    • (1996) Hum. Gene Ther , vol.7 , Issue.17 , pp. 2123
    • Wolfert, M.A.1    Schacht, E.H.2    Toncheva, V.3    Ulbrich, K.4    Nazarova, O.5    Seymour, L.W.6
  • 95
    • 0032496287 scopus 로고    scopus 로고
    • Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers
    • Toncheva, V.; Wolfert, M.A.; Dash, P.R.; Oupicky, D.; Ulbrich, K.; Seymour, L.W.; Schacht, E.H. Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers. Biochim. Biophys. Acta, 1998, 1380 (3), 354.
    • (1998) Biochim. Biophys. Acta , vol.1380 , Issue.3 , pp. 354
    • Toncheva, V.1    Wolfert, M.A.2    Dash, P.R.3    Oupicky, D.4    Ulbrich, K.5    Seymour, L.W.6    Schacht, E.H.7
  • 96
    • 0035871674 scopus 로고    scopus 로고
    • Systemic circulation of poly(L-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: Differential circulation in mice and rats and the implications for human gene therapy
    • Ward, C.M.; Read, M.L.; Seymour, L.W. Systemic circulation of poly(L-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene therapy. Blood, 2001, 97 (8), 2221.
    • (2001) Blood , vol.97 , Issue.8 , pp. 2221
    • Ward, C.M.1    Read, M.L.2    Seymour, L.W.3
  • 97
    • 0034635467 scopus 로고    scopus 로고
    • Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin
    • Dash, P.R.; Read, M.L.; Fisher, K.D.; Howard, K.A.; Wolfert, M.; Oupicky, D.; Subr, V.; Strohalm, J.; Ulbrich, K.; Seymour, L.W. Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin. J. Biol. Chem., 2000, 275 (6), 3793.
    • (2000) J. Biol. Chem , vol.275 , Issue.6 , pp. 3793
    • Dash, P.R.1    Read, M.L.2    Fisher, K.D.3    Howard, K.A.4    Wolfert, M.5    Oupicky, D.6    Subr, V.7    Strohalm, J.8    Ulbrich, K.9    Seymour, L.W.10
  • 99
  • 101
    • 0034623567 scopus 로고    scopus 로고
    • Degradable Poly(b-amino esters): Synthesis, characterization, and self-assembly with plasmid DNA
    • Lynn, D.M.; Langer, R. Degradable Poly(b-amino esters): Synthesis, characterization, and self-assembly with plasmid DNA. J. Am. Chem. Soc., 2000, 122, 10761.
    • (2000) J. Am. Chem. Soc , vol.122 , pp. 10761
    • Lynn, D.M.1    Langer, R.2
  • 102
    • 14044272234 scopus 로고    scopus 로고
    • Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters)
    • Anderson, D.G.; Akinc, A.; Hossain, N.; Langer, R. Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters). Mol. Ther., 2005, 11 (3), 426.
    • (2005) Mol. Ther , vol.11 , Issue.3 , pp. 426
    • Anderson, D.G.1    Akinc, A.2    Hossain, N.3    Langer, R.4
  • 103
    • 0042311016 scopus 로고    scopus 로고
    • Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery
    • Anderson, D.G.; Lynn, D.M.; Langer, R. Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. Angew. Chem. Int. Ed. Engl., 2003, 42 (27), 3153.
    • (2003) Angew. Chem. Int. Ed. Engl , vol.42 , Issue.27 , pp. 3153
    • Anderson, D.G.1    Lynn, D.M.2    Langer, R.3
  • 105
    • 0035780991 scopus 로고    scopus 로고
    • Convergent dendrons and dendrimers: From synthesis to applications
    • Grayson, S.M.; Frechet, J.M. Convergent dendrons and dendrimers: from synthesis to applications. Chem. Rev., 2001, 101 (12), 3819.
    • (2001) Chem. Rev , vol.101 , Issue.12 , pp. 3819
    • Grayson, S.M.1    Frechet, J.M.2
  • 107
    • 0030743086 scopus 로고    scopus 로고
    • The interaction of plasmid DNA with polyamidoamine dendrimers: Mechanism of complex formation and analysis of alterations induced in nuclease sensitivity and transcriptional activity of the complexed DNA
    • Bielinska, A.U.; Kukowska-Latallo, J.F.; Baker, J.R., Jr. The interaction of plasmid DNA with polyamidoamine dendrimers: mechanism of complex formation and analysis of alterations induced in nuclease sensitivity and transcriptional activity of the complexed DNA. Biochim. Biophys. Acta, 1997, 1353 (2), 180.
    • (1997) Biochim. Biophys. Acta , vol.1353 , Issue.2 , pp. 180
    • Bielinska, A.U.1    Kukowska-Latallo, J.F.2    Baker Jr., J.R.3
  • 108
    • 0033200186 scopus 로고    scopus 로고
    • DNA complexing with polyamidoamine dendrimers: Implications for transfection
    • Bielinska, A.U.; Chen, C.; Johnson, J.; Baker, J.R., Jr. DNA complexing with polyamidoamine dendrimers: implications for transfection. Bioconjug. Chem., 1999, 10 (5), 843.
    • (1999) Bioconjug. Chem , vol.10 , Issue.5 , pp. 843
    • Bielinska, A.U.1    Chen, C.2    Johnson, J.3    Baker Jr., J.R.4
  • 109
    • 0030775528 scopus 로고    scopus 로고
    • The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes
    • Tang, M.X.; Szoka, F.C. The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther., 1997, 4 (8), 823.
    • (1997) Gene Ther , vol.4 , Issue.8 , pp. 823
    • Tang, M.X.1    Szoka, F.C.2
  • 110
    • 2542619848 scopus 로고    scopus 로고
    • Gene delivery by dendrimers operates via a cholesterol dependent pathway
    • Manunta, M.; Tan, P.H.; Sagoo, P.; Kashefi, K.; George, A.J. Gene delivery by dendrimers operates via a cholesterol dependent pathway. Nucleic Acids Res., 2004, 32 (9), 2730.
    • (2004) Nucleic Acids Res , vol.32 , Issue.9 , pp. 2730
    • Manunta, M.1    Tan, P.H.2    Sagoo, P.3    Kashefi, K.4    George, A.J.5
  • 111
    • 0027655718 scopus 로고
    • Polyamidoamine cascade polymers mediate efficient transfection of cells in culture
    • Haensler, J.; Szoka, F.C., Jr. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug. Chem., 1993, 4 (5), 372.
    • (1993) Bioconjug. Chem , vol.4 , Issue.5 , pp. 372
    • Haensler, J.1    Szoka Jr., F.C.2
  • 112
    • 0035342007 scopus 로고    scopus 로고
    • Poly(amidoamine) (PAMAM) dendrimers: From biomimicry to drug delivery and biomedical applications
    • Esfand, R.; Tomalia, D.A. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discov. Today, 2001, 6 (8), 427.
    • (2001) Drug Discov. Today , vol.6 , Issue.8 , pp. 427
    • Esfand, R.1    Tomalia, D.A.2
  • 115
    • 0346724871 scopus 로고    scopus 로고
    • Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications
    • Berger, J.; Reist, M.; Mayer, J.M.; Felt, O.; Gurny, R. Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. Eur. J. Pharm. Biopharm., 2004, 57 (1), 35.
    • (2004) Eur. J. Pharm. Biopharm , vol.57 , Issue.1 , pp. 35
    • Berger, J.1    Reist, M.2    Mayer, J.M.3    Felt, O.4    Gurny, R.5
  • 116
    • 0032990267 scopus 로고    scopus 로고
    • Potential of low molecular mass chitosan as a DNA delivery system: Biocompatibility, body distribution and ability to complex and protect DNA
    • Richardson, S.C.; Kolbe, H.V.; Duncan, R. Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA. Int. J. Pharm., 1999, 178 (2), 231.
    • (1999) Int. J. Pharm , vol.178 , Issue.2 , pp. 231
    • Richardson, S.C.1    Kolbe, H.V.2    Duncan, R.3
  • 118
    • 0036027454 scopus 로고    scopus 로고
    • Quaternized chitosan oligomers as novel gene delivery vectors in epithelial cell lines
    • Thanou, M.; Florea, B.I.; Geldof, M.; Junginger, H.E.; Borchard, G. Quaternized chitosan oligomers as novel gene delivery vectors in epithelial cell lines. Biomaterials, 2002, 23 (1), 153.
    • (2002) Biomaterials , vol.23 , Issue.1 , pp. 153
    • Thanou, M.1    Florea, B.I.2    Geldof, M.3    Junginger, H.E.4    Borchard, G.5
  • 119
    • 2542550408 scopus 로고    scopus 로고
    • Structural analysis of chitosan mediated DNA condensation by AFM: Influence of chitosan molecular parameters
    • Danielsen, S.; Varum, K.M.; Stokke, B.T. Structural analysis of chitosan mediated DNA condensation by AFM: influence of chitosan molecular parameters. Biomacromolecules, 2004, 5 (3), 928.
    • (2004) Biomacromolecules , vol.5 , Issue.3 , pp. 928
    • Danielsen, S.1    Varum, K.M.2    Stokke, B.T.3
  • 122
    • 0037340617 scopus 로고    scopus 로고
    • Mesenchymal stem cells, MG63 and HEK293 transfection using chitosan-DNA nanoparticles
    • Corsi, K.; Chellat, F.; Yahia, L.; Fernandes, J.C. Mesenchymal stem cells, MG63 and HEK293 transfection using chitosan-DNA nanoparticles. Biomaterials, 2003, 24 (7), 1255.
    • (2003) Biomaterials , vol.24 , Issue.7 , pp. 1255
    • Corsi, K.1    Chellat, F.2    Yahia, L.3    Fernandes, J.C.4
  • 123
    • 0035424424 scopus 로고    scopus 로고
    • In vitro gene delivery mediated by chitosan. effect of pH, serum, and molecular mass of chitosan on the transfection efficiency
    • Sato, T.; Ishii, T.; Okahata, Y. In vitro gene delivery mediated by chitosan. effect of pH, serum, and molecular mass of chitosan on the transfection efficiency. Biomaterials, 2001, 22 (15), 2075.
    • (2001) Biomaterials , vol.22 , Issue.15 , pp. 2075
    • Sato, T.1    Ishii, T.2    Okahata, Y.3
  • 124
    • 0031722107 scopus 로고    scopus 로고
    • Chitosan-based vector/DNA complexes for gene delivery: Biophysical characteristics and transfection ability
    • Erbacher, P.; Zou, S.; Bettinger, T.; Steffan, A.M.; Remy, J.S. Chitosan-based vector/DNA complexes for gene delivery: biophysical characteristics and transfection ability. Pharm. Res., 1998, 15 (9), 1332.
    • (1998) Pharm. Res , vol.15 , Issue.9 , pp. 1332
    • Erbacher, P.1    Zou, S.2    Bettinger, T.3    Steffan, A.M.4    Remy, J.S.5
  • 125
    • 0032958073 scopus 로고    scopus 로고
    • Oral gene delivery with chitosan - DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
    • Roy, K.; Mao, H.Q.; Huang, S.K.; Leong, K.W. Oral gene delivery with chitosan - DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat. Med., 1999, 5 (4), 387.
    • (1999) Nat. Med , vol.5 , Issue.4 , pp. 387
    • Roy, K.1    Mao, H.Q.2    Huang, S.K.3    Leong, K.W.4
  • 127
    • 0037471402 scopus 로고    scopus 로고
    • Nasal delivery of chitosan-DNA plasmid expressing epitopes of respiratory syncytial virus (RSV) induces protective CTL responses in BALB/c mice
    • Iqbal, M.; Lin, W.; Jabbal-Gill, I.; Davis, S.S.; Steward, M.W.; Illum, L. Nasal delivery of chitosan-DNA plasmid expressing epitopes of respiratory syncytial virus (RSV) induces protective CTL responses in BALB/c mice. Vaccine, 2003, 21 (13), 1478.
    • (2003) Vaccine , vol.21 , Issue.13 , pp. 1478
    • Iqbal, M.1    Lin, W.2    Jabbal-Gill, I.3    Davis, S.S.4    Steward, M.W.5    Illum, L.6
  • 128
    • 5444267326 scopus 로고    scopus 로고
    • Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers
    • Koping-Hoggard, M.; Varum, K.M.; Issa, M.; Danielsen, S.; Christensen, B.E.; Stokke, B.T.; Artursson, P. Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers. Gene Ther., 2004, 11 (19), 1441.
    • (2004) Gene Ther , vol.11 , Issue.19 , pp. 1441
    • Koping-Hoggard, M.1    Varum, K.M.2    Issa, M.3    Danielsen, S.4    Christensen, B.E.5    Stokke, B.T.6    Artursson, P.7
  • 130
    • 0035801903 scopus 로고    scopus 로고
    • Mechanism of cell transfection with plasmid/chitosan complexes
    • Ishii, T.; Okahata, Y.; Sato, T. Mechanism of cell transfection with plasmid/chitosan complexes. Biochim. Biophys. Acta, 2001, 1514 (1), 51.
    • (2001) Biochim. Biophys. Acta , vol.1514 , Issue.1 , pp. 51
    • Ishii, T.1    Okahata, Y.2    Sato, T.3
  • 131
    • 0038686295 scopus 로고    scopus 로고
    • Targeting of Synthetic Gene Delivery Systems
    • Schatzlein, A.G. Targeting of Synthetic Gene Delivery Systems. J. Biomed. Biotechnol., 2003, 2003 (2), 149.
    • (2003) J. Biomed. Biotechnol , vol.2003 , Issue.2 , pp. 149
    • Schatzlein, A.G.1
  • 132
    • 0035965501 scopus 로고    scopus 로고
    • Gene delivery with synthetic (non viral) carriers
    • Brown, M.D.; Schatzlein, A.G.; Uchegbu, I.F. Gene delivery with synthetic (non viral) carriers. Int. J. Pharm., 2001, 229 (1-2), 1.
    • (2001) Int. J. Pharm , vol.229 , Issue.1-2 , pp. 1
    • Brown, M.D.1    Schatzlein, A.G.2    Uchegbu, I.F.3
  • 133
    • 0034294817 scopus 로고    scopus 로고
    • Development of biomaterials for gene therapy
    • Han, S.; Mahato, R.I.; Sung, Y.K.; Kim, S.W. Development of biomaterials for gene therapy. Mol. Ther., 2000, 2 (4), 302.
    • (2000) Mol. Ther , vol.2 , Issue.4 , pp. 302
    • Han, S.1    Mahato, R.I.2    Sung, Y.K.3    Kim, S.W.4
  • 135
    • 0029799791 scopus 로고    scopus 로고
    • A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: Polyethylenimine
    • Abdallah, B.; Hassan, A.; Benoist, C.; Goula, D.; Behr, J.P.; Demeneix, B.A. A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Hum. Gene Ther., 1996, 7 (16), 1947.
    • (1996) Hum. Gene Ther , vol.7 , Issue.16 , pp. 1947
    • Abdallah, B.1    Hassan, A.2    Benoist, C.3    Goula, D.4    Behr, J.P.5    Demeneix, B.A.6
  • 136
    • 0031860769 scopus 로고    scopus 로고
    • Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system
    • Goula, D.; Remy, J.S.; Erbacher, P.; Wasowicz, M.; Levi, G.; Abdallah, B.; Demeneix, B.A. Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system. Gene Ther., 1998, 5 (5), 712.
    • (1998) Gene Ther , vol.5 , Issue.5 , pp. 712
    • Goula, D.1    Remy, J.S.2    Erbacher, P.3    Wasowicz, M.4    Levi, G.5    Abdallah, B.6    Demeneix, B.A.7
  • 139
    • 0030729180 scopus 로고    scopus 로고
    • ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo
    • Ferrari, S.; Moro, E.; Pettenazzo, A.; Behr, J.P.; Zacchello, F.; Scarpa, M. ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo. Gene Ther., 1997, 4 (10), 1100.
    • (1997) Gene Ther , vol.4 , Issue.10 , pp. 1100
    • Ferrari, S.1    Moro, E.2    Pettenazzo, A.3    Behr, J.P.4    Zacchello, F.5    Scarpa, M.6
  • 141
    • 33645242924 scopus 로고    scopus 로고
    • Pharmacokinetics of plasmid DNA-based non-viral gene medicine
    • Nishikawa, M.; Takakura, Y.; Hashida, M. Pharmacokinetics of plasmid DNA-based non-viral gene medicine. Adv. Genet., 2005, 53, 47.
    • (2005) Adv. Genet , vol.53 , pp. 47
    • Nishikawa, M.1    Takakura, Y.2    Hashida, M.3
  • 142
    • 27844495150 scopus 로고    scopus 로고
    • Current developments in gene transfection agents
    • Azzam, T.; Domb, A.J. Current developments in gene transfection agents. Curr Drug Deliv, 2004, 1 (2), 165.
    • (2004) Curr Drug Deliv , vol.1 , Issue.2 , pp. 165
    • Azzam, T.1    Domb, A.J.2
  • 143
    • 0035401236 scopus 로고    scopus 로고
    • Nonviral gene therapy
    • Li, S.; Ma, Z. Nonviral gene therapy. Curr. Gene Ther., 2001, 1 (2), 201.
    • (2001) Curr. Gene Ther , vol.1 , Issue.2 , pp. 201
    • Li, S.1    Ma, Z.2
  • 144
    • 1342345175 scopus 로고    scopus 로고
    • Phage φ integrases-mediated situ-specific integration for gene therapy
    • Olivares, E.C.; Calos, M.P. Phage φ integrases-mediated situ-specific integration for gene therapy. Gene Ther. Reg., 2003, 2 (2), 103.
    • (2003) Gene Ther. Reg , vol.2 , Issue.2 , pp. 103
    • Olivares, E.C.1    Calos, M.P.2
  • 145
    • 33749536744 scopus 로고    scopus 로고
    • Transposons for Gene Therapy
    • Ivics, Z. Transposons for Gene Therapy. Curr. Gene Ther., 2006, 6 (5), 593.
    • (2006) Curr. Gene Ther , vol.6 , Issue.5 , pp. 593
    • Ivics, Z.1
  • 146
    • 0035126943 scopus 로고    scopus 로고
    • Polymeric controlled drug-delivery systems: Perspective issues and opportunities
    • Kumar, M.N.; Kumar, N. Polymeric controlled drug-delivery systems: perspective issues and opportunities. Drug Dev. Ind. Pharm., 2001, 27 (1), 1.
    • (2001) Drug Dev. Ind. Pharm , vol.27 , Issue.1 , pp. 1
    • Kumar, M.N.1    Kumar, N.2
  • 147
    • 0033017213 scopus 로고    scopus 로고
    • DNA delivery from polymer matrices for tissue engineering
    • Shea, L.D.; Smiley, E.; Bonadio, J.; Mooney, D.J. DNA delivery from polymer matrices for tissue engineering. Nat. Biotechnol., 1999, 17 (6), 551.
    • (1999) Nat. Biotechnol , vol.17 , Issue.6 , pp. 551
    • Shea, L.D.1    Smiley, E.2    Bonadio, J.3    Mooney, D.J.4
  • 149
    • 0025047522 scopus 로고
    • New methods of drug delivery
    • Langer, R. New methods of drug delivery. Science, 1990, 249 (4976), 1527.
    • (1990) Science , vol.249 , Issue.4976 , pp. 1527
    • Langer, R.1
  • 150
    • 0032479766 scopus 로고    scopus 로고
    • Gene Therapy for tissue repair and regeneration
    • Levy, R.J.; Goldstein, S.A.; Bonadio, J. Gene Therapy for tissue repair and regeneration. Adv. Drug Deliv. Rev., 1998, 33 (1-2), 53.
    • (1998) Adv. Drug Deliv. Rev , vol.33 , Issue.1-2 , pp. 53
    • Levy, R.J.1    Goldstein, S.A.2    Bonadio, J.3
  • 151
    • 27844463051 scopus 로고    scopus 로고
    • Nanotechnology for drug and gene therapy: The importance of understanding molecular mechanisms of delivery
    • Labhasetwar, V. Nanotechnology for drug and gene therapy: the importance of understanding molecular mechanisms of delivery. Curr. Opin. Biotechnol., 2005, 16 (6), 674.
    • (2005) Curr. Opin. Biotechnol , vol.16 , Issue.6 , pp. 674
    • Labhasetwar, V.1
  • 152
    • 0034670057 scopus 로고    scopus 로고
    • Tissue engineering via local gene delivery: Update and future prospects for enhancing the technology
    • Bonadio, J. Tissue engineering via local gene delivery: update and future prospects for enhancing the technology. Adv. Drug Deliv. Rev., 2000, 44 (2-3), 185.
    • (2000) Adv. Drug Deliv. Rev , vol.44 , Issue.2-3 , pp. 185
    • Bonadio, J.1
  • 154
    • 0037462997 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    • Panyam, J.; Labhasetwar, V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev., 2003, 55 (3), 329.
    • (2003) Adv. Drug Deliv. Rev , vol.55 , Issue.3 , pp. 329
    • Panyam, J.1    Labhasetwar, V.2
  • 155
    • 0037006590 scopus 로고    scopus 로고
    • Co-delivery of an antisense oligonucleotide and 5-fluorouracil using sustained release poly (lactide-coglycolide) microsphere formulations for potential combination therapy in cancer
    • Hussain, M.; Beale, G.; Hughes, M.; Akhtar, S. Co-delivery of an antisense oligonucleotide and 5-fluorouracil using sustained release poly (lactide-coglycolide) microsphere formulations for potential combination therapy in cancer. Int. J. Pharm., 2002, 234 (1-2), 129.
    • (2002) Int. J. Pharm , vol.234 , Issue.1-2 , pp. 129
    • Hussain, M.1    Beale, G.2    Hughes, M.3    Akhtar, S.4
  • 156
    • 0037453175 scopus 로고    scopus 로고
    • A new delivery system for antisense therapy: PLGA microspheres encapsulating oligonucleotide/polyethyleneimine solid complexes
    • De Rosa, G.; Bochot, A.; Quaglia, F.; Besnard, M.; Fattal, E. A new delivery system for antisense therapy: PLGA microspheres encapsulating oligonucleotide/polyethyleneimine solid complexes. Int. J. Pharm., 2003, 254 (1), 89.
    • (2003) Int. J. Pharm , vol.254 , Issue.1 , pp. 89
    • De Rosa, G.1    Bochot, A.2    Quaglia, F.3    Besnard, M.4    Fattal, E.5
  • 157
    • 4644293047 scopus 로고    scopus 로고
    • Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: In vitro and in vivo studies
    • Khan, A.; Benboubetra, M.; Sayyed, P.Z.; Ng, K.W.; Fox, S.; Beck, G.; Benter, I.F.; Akhtar, S. Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies. J. Drug Target., 2004, 12 (6), 393.
    • (2004) J. Drug Target , vol.12 , Issue.6 , pp. 393
    • Khan, A.1    Benboubetra, M.2    Sayyed, P.Z.3    Ng, K.W.4    Fox, S.5    Beck, G.6    Benter, I.F.7    Akhtar, S.8
  • 158
    • 0343247711 scopus 로고    scopus 로고
    • Biodegradation and biocompatibility of PLA and PLGA microspheres
    • Shive, M.S.; Anderson, J.M. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv. Drug Deliv. Rev., 1997, 28 (1), 5.
    • (1997) Adv. Drug Deliv. Rev , vol.28 , Issue.1 , pp. 5
    • Shive, M.S.1    Anderson, J.M.2
  • 159
    • 1542647233 scopus 로고    scopus 로고
    • Controlled release of bioactive agents in gene therapy and tissue engineering
    • Sendil Keskin, D.; Hasirci, V. Controlled release of bioactive agents in gene therapy and tissue engineering. Adv. Exp. Med. Biol., 2003, 543, 279.
    • (2003) Adv. Exp. Med. Biol , vol.543 , pp. 279
    • Sendil Keskin, D.1    Hasirci, V.2
  • 160
    • 0034913116 scopus 로고    scopus 로고
    • Nonviral vectors in the new millennium: Delivery barriers in gene transfer
    • Nishikawa, M.; Huang, L. Nonviral vectors in the new millennium: delivery barriers in gene transfer. Hum. Gene Ther., 2001, 12 (8), 861.
    • (2001) Hum. Gene Ther , vol.12 , Issue.8 , pp. 861
    • Nishikawa, M.1    Huang, L.2
  • 161
    • 0037072576 scopus 로고    scopus 로고
    • Prospects for cationic polymers in gene and oligonucleotide therapy against cancer
    • Merdan, T.; Kopecek, J.; Kissel, T. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv. Drug Deliv. Rev., 2002, 54 (5), 715.
    • (2002) Adv. Drug Deliv. Rev , vol.54 , Issue.5 , pp. 715
    • Merdan, T.1    Kopecek, J.2    Kissel, T.3
  • 163
    • 0032855232 scopus 로고    scopus 로고
    • Microencapsulation of DNA using poly(DL-lactide-co-glycolide): Stability issues and release characteristics
    • Walter, E.; Moelling, K.; Pavlovic, J.; Merkle, H.P. Microencapsulation of DNA using poly(DL-lactide-co-glycolide): stability issues and release characteristics. J. Control. Release, 1999, 61 (3), 361.
    • (1999) J. Control. Release , vol.61 , Issue.3 , pp. 361
    • Walter, E.1    Moelling, K.2    Pavlovic, J.3    Merkle, H.P.4
  • 164
    • 0023041422 scopus 로고
    • Expression of transfected DNA depends on DNA topology
    • Weintraub, H.; Cheng, P.F.; Conrad, K. Expression of transfected DNA depends on DNA topology. Cell, 1986, 46 (1), 115.
    • (1986) Cell , vol.46 , Issue.1 , pp. 115
    • Weintraub, H.1    Cheng, P.F.2    Conrad, K.3
  • 165
    • 0030222362 scopus 로고    scopus 로고
    • Tetanus toxoid and synthetic malaria antigen containing poly(lactide)/ poly(lactide-coglycolide) microspheres: Importance of polymer degradation and antigen release for immune response
    • Thomasin, C.; Corradin, G.; Ying, M.; Merkle, H.P.; Gander, B. Tetanus toxoid and synthetic malaria antigen containing poly(lactide)/ poly(lactide-coglycolide) microspheres: Importance of polymer degradation and antigen release for immune response. J. Control. Release, 1996, 41 (1), 131.
    • (1996) J. Control. Release , vol.41 , Issue.1 , pp. 131
    • Thomasin, C.1    Corradin, G.2    Ying, M.3    Merkle, H.P.4    Gander, B.5
  • 167
    • 33646851754 scopus 로고    scopus 로고
    • Versatility of biodegradable poly(d,l-lactic-coglycolic acid) microspheres for plasmid DNA delivery
    • Diez, S.; Tros de Ilarduya, C. Versatility of biodegradable poly(d,l-lactic-coglycolic acid) microspheres for plasmid DNA delivery. Eur. J. Pharm. Biopharm., 2006, 63 (2), 188.
    • (2006) Eur. J. Pharm. Biopharm , vol.63 , Issue.2 , pp. 188
    • Diez, S.1    Tros de Ilarduya, C.2
  • 169
    • 0030920599 scopus 로고    scopus 로고
    • Controlled release of plasmid DNA
    • Jong, Y.S. Controlled release of plasmid DNA J. Contol. Release, 1997, 47 123.
    • (1997) J. Contol. Release , vol.47 , pp. 123
    • Jong, Y.S.1
  • 171
    • 0038015498 scopus 로고    scopus 로고
    • Controlled gene delivery system based on thermosensitive biodegradable hydrogel
    • Li, Z.; Ning, W.; Wang, J.; Choi, A.; Lee, P.Y.; Tyagi, P.; Huang, L. Controlled gene delivery system based on thermosensitive biodegradable hydrogel. Pharm. Res., 2003, 20 (6), 884.
    • (2003) Pharm. Res , vol.20 , Issue.6 , pp. 884
    • Li, Z.1    Ning, W.2    Wang, J.3    Choi, A.4    Lee, P.Y.5    Tyagi, P.6    Huang, L.7
  • 172
    • 0042836837 scopus 로고    scopus 로고
    • Formulations containing poly(lactide-co-glycolide) and plasmid DNA expression vectors
    • Hedley, M.L. Formulations containing poly(lactide-co-glycolide) and plasmid DNA expression vectors. Expert Opin. Biol. Ther., 2003, 3 (6), 903.
    • (2003) Expert Opin. Biol. Ther , vol.3 , Issue.6 , pp. 903
    • Hedley, M.L.1
  • 173
    • 0035342311 scopus 로고    scopus 로고
    • Biomaterials for gene delivery: Atelocollagen-mediated controlled release of molecular medicines
    • Ochiya, T.; Nagahara, S.; Sano, A.; Itoh, H.; Terada, M. Biomaterials for gene delivery: atelocollagen-mediated controlled release of molecular medicines. Curr. Gene Ther., 2001, 1 (1), 31.
    • (2001) Curr. Gene Ther , vol.1 , Issue.1 , pp. 31
    • Ochiya, T.1    Nagahara, S.2    Sano, A.3    Itoh, H.4    Terada, M.5
  • 174
    • 0034580371 scopus 로고    scopus 로고
    • The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices
    • Jain, R.A. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials, 2000, 21 (23), 2475.
    • (2000) Biomaterials , vol.21 , Issue.23 , pp. 2475
    • Jain, R.A.1
  • 175
    • 0036737338 scopus 로고    scopus 로고
    • Robust and prolonged gene expression from injectable polymeric implants
    • Eliaz, R.E.; Szoka, F.C., Jr. Robust and prolonged gene expression from injectable polymeric implants. Gene Ther., 2002, 9 (18), 1230.
    • (2002) Gene Ther , vol.9 , Issue.18 , pp. 1230
    • Eliaz, R.E.1    Szoka Jr., F.C.2
  • 176
    • 0037161339 scopus 로고    scopus 로고
    • Biodegradable injectable in situ forming drug delivery systems
    • Hatefi, A.; Amsden, B. Biodegradable injectable in situ forming drug delivery systems. J. Control. Release, 2002, 80 (1-3), 9.
    • (2002) J. Control. Release , vol.80 , Issue.1-3 , pp. 9
    • Hatefi, A.1    Amsden, B.2
  • 177
    • 4444330267 scopus 로고    scopus 로고
    • Biomaterials: Where we have been and where we are going
    • Ratner, B.D.; Bryant, S.J. Biomaterials: where we have been and where we are going. Annu. Rev. Biomed. Eng., 2004, 6, 41.
    • (2004) Annu. Rev. Biomed. Eng , vol.6 , pp. 41
    • Ratner, B.D.1    Bryant, S.J.2
  • 178
    • 33745284997 scopus 로고    scopus 로고
    • Natural polymers for gene delivery and tissue engineering
    • Dang, J.M.; Leong, K.W. Natural polymers for gene delivery and tissue engineering. Adv. Drug Deliv. Rev., 2006, 58 (4), 487.
    • (2006) Adv. Drug Deliv. Rev , vol.58 , Issue.4 , pp. 487
    • Dang, J.M.1    Leong, K.W.2
  • 179
    • 3042814407 scopus 로고    scopus 로고
    • Controlled release systems for DNA delivery
    • Pannier, A.K.; Shea, L.D. Controlled release systems for DNA delivery. Mol. Ther., 2004, 10 (1), 19.
    • (2004) Mol. Ther , vol.10 , Issue.1 , pp. 19
    • Pannier, A.K.1    Shea, L.D.2
  • 180
    • 0017536938 scopus 로고
    • Collagen sponge: Theory and practice of medical applications
    • Chvapil, M. Collagen sponge: theory and practice of medical applications. J. Biomed. Mater. Res., 1977, 11 (5), 721.
    • (1977) J. Biomed. Mater. Res , vol.11 , Issue.5 , pp. 721
    • Chvapil, M.1
  • 181
    • 0030969215 scopus 로고    scopus 로고
    • Hirasawa, T.; Sano, A.; Fujioka, K.; Inoue, K.; Miyata, K.; Minoru; Nakano; Yamashita, K.; Hayakawa, T. Biodegradability of Minipellet a new drug formulation using atelocollagen as a drug carrier material, in rhesus monkey. Biomed. Res., 1997, 18 (2), 149.
    • Hirasawa, T.; Sano, A.; Fujioka, K.; Inoue, K.; Miyata, K.; Minoru; Nakano; Yamashita, K.; Hayakawa, T. Biodegradability of Minipellet a new drug formulation using atelocollagen as a drug carrier material, in rhesus monkey. Biomed. Res., 1997, 18 (2), 149.
  • 184
    • 0029434529 scopus 로고
    • Recent developments of collagen-based materials for medical applications and drug delivery systems
    • Rao, K.P. Recent developments of collagen-based materials for medical applications and drug delivery systems. J. Biomater. Sci. Polym. Ed., 1995, 7 (7), 623.
    • (1995) J. Biomater. Sci. Polym. Ed , vol.7 , Issue.7 , pp. 623
    • Rao, K.P.1
  • 185
    • 33749990846 scopus 로고    scopus 로고
    • The use of injectable collagens for aesthetic rejuvenation
    • Matarasso, S.L. The use of injectable collagens for aesthetic rejuvenation. Semin. Cutan. Med. Surg., 2006, 25 (3), 151.
    • (2006) Semin. Cutan. Med. Surg , vol.25 , Issue.3 , pp. 151
    • Matarasso, S.L.1
  • 186
    • 0034814202 scopus 로고    scopus 로고
    • Gelatin: A valuable protein for food and pharmaceutical industries: review
    • Djagny, V.B.; Wang, Z.; Xu, S. Gelatin: a valuable protein for food and pharmaceutical industries: review. Crit. Rev. Food Sci. Nutr., 2001, 41 (6), 481.
    • (2001) Crit. Rev. Food Sci. Nutr , vol.41 , Issue.6 , pp. 481
    • Djagny, V.B.1    Wang, Z.2    Xu, S.3
  • 187
    • 28444469746 scopus 로고    scopus 로고
    • Gelatin as a delivery vehicle for the controlled release of bioactive molecules
    • Young, S.; Wong, M.; Tabata, Y.; Mikos, A.G. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J. Control. Release, 2005, 109 (1-3), 256.
    • (2005) J. Control. Release , vol.109 , Issue.1-3 , pp. 256
    • Young, S.1    Wong, M.2    Tabata, Y.3    Mikos, A.G.4
  • 188
    • 21744457627 scopus 로고    scopus 로고
    • A new gene delivery system based on controlled release technology
    • Kushibiki, T.; Tabata, Y. A new gene delivery system based on controlled release technology. Curr. Drug Deliv., 2004, 1 (2), 153.
    • (2004) Curr. Drug Deliv , vol.1 , Issue.2 , pp. 153
    • Kushibiki, T.1    Tabata, Y.2
  • 189
    • 33745634172 scopus 로고    scopus 로고
    • Controlled release of plasmid DNA from hydrogels prepared from gelatin cationized by different amine compounds
    • Kushibiki, T.; Tomoshige, R.; Iwanaga, K.; Kakemi, M.; Tabata, Y. Controlled release of plasmid DNA from hydrogels prepared from gelatin cationized by different amine compounds. J. Control. Release, 2006, 112 (2), 249.
    • (2006) J. Control. Release , vol.112 , Issue.2 , pp. 249
    • Kushibiki, T.1    Tomoshige, R.2    Iwanaga, K.3    Kakemi, M.4    Tabata, Y.5
  • 191
    • 0014648097 scopus 로고
    • Immunochemistry and immunology of collagen and gelatin
    • Schwick, H.G.; Heide, K. Immunochemistry and immunology of collagen and gelatin. Bibl. Haematol., 1969, 33, 111.
    • (1969) Bibl. Haematol , vol.33 , pp. 111
    • Schwick, H.G.1    Heide, K.2
  • 192
    • 0037161331 scopus 로고    scopus 로고
    • Controlled release of plasmid DNA from cationized gelatin hydrogels based on hydrogel degradation
    • Fukunaka, Y.; Iwanaga, K.; Morimoto, K.; Kakemi, M.; Tabata, Y. Controlled release of plasmid DNA from cationized gelatin hydrogels based on hydrogel degradation. J. Control. Release, 2002, 80 (1-3), 333.
    • (2002) J. Control. Release , vol.80 , Issue.1-3 , pp. 333
    • Fukunaka, Y.1    Iwanaga, K.2    Morimoto, K.3    Kakemi, M.4    Tabata, Y.5
  • 193
    • 0038179220 scopus 로고    scopus 로고
    • In vivo release and gene expression of plasmid DNA by hydrogels of gelatin with different cationization extents
    • Kushibiki, T.; Tomoshige, R.; Fukunaka, Y.; Kakemi, M.; Tabata, Y. In vivo release and gene expression of plasmid DNA by hydrogels of gelatin with different cationization extents. J. Control. Release, 2003, 90 (2), 207.
    • (2003) J. Control. Release , vol.90 , Issue.2 , pp. 207
    • Kushibiki, T.1    Tomoshige, R.2    Fukunaka, Y.3    Kakemi, M.4    Tabata, Y.5
  • 194
    • 0032482156 scopus 로고    scopus 로고
    • Protein release from gelatin matrices
    • Ikada, Y.; Tabata, Y. Protein release from gelatin matrices. Adv. Drug Deliv. Rev., 1998, 31 (3), 287.
    • (1998) Adv. Drug Deliv. Rev , vol.31 , Issue.3 , pp. 287
    • Ikada, Y.1    Tabata, Y.2
  • 195
    • 22644441692 scopus 로고    scopus 로고
    • Gelatin nanoparticles as a new and simple gene delivery system
    • Zwiorek, K.; Kloeckner, J.; Wagner, E.; Coester, C. Gelatin nanoparticles as a new and simple gene delivery system. J. Pharm. Pharm. Sci., 2005, 7 (4), 22.
    • (2005) J. Pharm. Pharm. Sci , vol.7 , Issue.4 , pp. 22
    • Zwiorek, K.1    Kloeckner, J.2    Wagner, E.3    Coester, C.4
  • 196
    • 25844473177 scopus 로고    scopus 로고
    • In vivo release of plasmid DNA from composites of oligo(poly(ethylene glycol)fumarate) and cationized gelatin microspheres
    • Kasper, F.K.; Kushibiki, T.; Kimura, Y.; Mikos, A.G.; Tabata, Y. In vivo release of plasmid DNA from composites of oligo(poly(ethylene glycol)fumarate) and cationized gelatin microspheres. J. Control Release, 2005, 107 (3), 547.
    • (2005) J. Control Release , vol.107 , Issue.3 , pp. 547
    • Kasper, F.K.1    Kushibiki, T.2    Kimura, Y.3    Mikos, A.G.4    Tabata, Y.5
  • 199
    • 0028845761 scopus 로고
    • Extracellular matrix, supramolecular organisation and shape
    • Scott, J.E. Extracellular matrix, supramolecular organisation and shape. J. Anat., 1995, 187 (Pt 2), 259.
    • (1995) J. Anat , vol.187 , Issue.PART 2 , pp. 259
    • Scott, J.E.1
  • 200
    • 0030766519 scopus 로고    scopus 로고
    • Hyaluronan in morphogenesis
    • Toole, B.P. Hyaluronan in morphogenesis. J. Intern. Med., 1997, 242 (1), 35.
    • (1997) J. Intern. Med , vol.242 , Issue.1 , pp. 35
    • Toole, B.P.1
  • 201
    • 0024368010 scopus 로고
    • Clinical uses of hyaluronan
    • discussion 275
    • Balazs, E.A.; Denlinger, J.L. Clinical uses of hyaluronan. Ciba Found. Symp., 1989, 143, 265; discussion 275, 281.
    • (1989) Ciba Found. Symp , vol.143 , Issue.265 , pp. 281
    • Balazs, E.A.1    Denlinger, J.L.2
  • 202
    • 27644576663 scopus 로고    scopus 로고
    • Hyaluronan: Pharmaceutical characterization and drug delivery
    • Liao, Y.H.; Jones, S.A.; Forbes, B.; Martin, G.P.; Brown, M.B. Hyaluronan: pharmaceutical characterization and drug delivery. Drug Deliv., 2005, 12 (6), 327.
    • (2005) Drug Deliv , vol.12 , Issue.6 , pp. 327
    • Liao, Y.H.1    Jones, S.A.2    Forbes, B.3    Martin, G.P.4    Brown, M.B.5
  • 203
    • 0028297463 scopus 로고
    • Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing
    • Goa, K.L.; Benfield, P. Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing. Drugs, 1994, 47 (3), 536.
    • (1994) Drugs , vol.47 , Issue.3 , pp. 536
    • Goa, K.L.1    Benfield, P.2
  • 205
    • 0030820093 scopus 로고    scopus 로고
    • Hyaluronan in skin
    • Juhlin, L. Hyaluronan in skin. J. Intern. Med., 1997, 242 (1), 61.
    • (1997) J. Intern. Med , vol.242 , Issue.1 , pp. 61
    • Juhlin, L.1
  • 207
    • 0031238639 scopus 로고    scopus 로고
    • Synthesis and in vitro degradation of new polyvalent hydrazide cross-linked hydrogels of hyaluronic acid
    • Vercruysse, K.P.; Marecak, D.M.; Marecek, J.F.; Prestwich, G.D. Synthesis and in vitro degradation of new polyvalent hydrazide cross-linked hydrogels of hyaluronic acid. Bioconjug. Chem., 1997, 8 (5), 686.
    • (1997) Bioconjug. Chem , vol.8 , Issue.5 , pp. 686
    • Vercruysse, K.P.1    Marecak, D.M.2    Marecek, J.F.3    Prestwich, G.D.4
  • 208
    • 0142155106 scopus 로고    scopus 로고
    • Hyaluronan microspheres for sustained gene delivery and site-specific targeting
    • Yun, Y.H.; Goetz, D.J.; Yellen, P.; Chen, W. Hyaluronan microspheres for sustained gene delivery and site-specific targeting. Biomaterials, 2004, 25 (1), 147.
    • (2004) Biomaterials , vol.25 , Issue.1 , pp. 147
    • Yun, Y.H.1    Goetz, D.J.2    Yellen, P.3    Chen, W.4
  • 209
    • 7444232477 scopus 로고    scopus 로고
    • DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach
    • Segura, T.; Chung, P.H.; Shea, L.D. DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach. Biomaterials, 2005, 26 (13), 1575.
    • (2005) Biomaterials , vol.26 , Issue.13 , pp. 1575
    • Segura, T.1    Chung, P.H.2    Shea, L.D.3
  • 210
    • 0037723921 scopus 로고    scopus 로고
    • Characterization of DNA-hyaluronan matrix for sustained gene transfer
    • Kim, A.; Checkla, D.M.; Dehazya, P.; Chen, W. Characterization of DNA-hyaluronan matrix for sustained gene transfer. J. Control. Release, 2003, 90 (1), 81.
    • (2003) J. Control. Release , vol.90 , Issue.1 , pp. 81
    • Kim, A.1    Checkla, D.M.2    Dehazya, P.3    Chen, W.4
  • 213
    • 0037130997 scopus 로고    scopus 로고
    • Genetically engineered silk-elastinlike protein polymers for controlled drug delivery
    • Megeed, Z.; Cappello, J.; Ghandehari, H. Genetically engineered silk-elastinlike protein polymers for controlled drug delivery. Adv. Drug Deliv. Rev., 2002, 54 (8), 1075.
    • (2002) Adv. Drug Deliv. Rev , vol.54 , Issue.8 , pp. 1075
    • Megeed, Z.1    Cappello, J.2    Ghandehari, H.3
  • 214
    • 0035997328 scopus 로고    scopus 로고
    • Controlled release of plasmid DNA from a genetically engineered silk-elastinlike hydrogel
    • Megeed, Z.; Cappello, J.; Ghandehari, H. Controlled release of plasmid DNA from a genetically engineered silk-elastinlike hydrogel. Pharm. Res., 2002, 19 (7), 954.
    • (2002) Pharm. Res , vol.19 , Issue.7 , pp. 954
    • Megeed, Z.1    Cappello, J.2    Ghandehari, H.3
  • 215
    • 0017317645 scopus 로고
    • Polymers for the sustained release of proteins and other macromolecules
    • Langer, R.; Folkman, J. Polymers for the sustained release of proteins and other macromolecules. Nature, 1976, 263 (5580), 797.
    • (1976) Nature , vol.263 , Issue.5580 , pp. 797
    • Langer, R.1    Folkman, J.2
  • 217
    • 12244313407 scopus 로고    scopus 로고
    • Gene expression and mucosal immune responses after vaginal DNA immunization in mice using a controlled delivery matrix
    • Shen, H.; Goldberg, E.; Saltzman, W.M. Gene expression and mucosal immune responses after vaginal DNA immunization in mice using a controlled delivery matrix. J. Control. Release, 2003, 86 (2-3), 339.
    • (2003) J. Control. Release , vol.86 , Issue.2-3 , pp. 339
    • Shen, H.1    Goldberg, E.2    Saltzman, W.M.3
  • 218
    • 10644240952 scopus 로고    scopus 로고
    • Wu, X.S. Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid polymers: Part III. Drug delivery application. Artif. Cells Blood Substit. Immobil. Biotechnol., 2004, 32 (4), 575.
    • Wu, X.S. Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid polymers: Part III. Drug delivery application. Artif. Cells Blood Substit. Immobil. Biotechnol., 2004, 32 (4), 575.
  • 219
    • 0035051160 scopus 로고    scopus 로고
    • Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid polymers. Part II: Biodegradation
    • Sci. Polym. Ed
    • Wu, X.S.; Wang, N. Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid polymers. Part II: biodegradation. J. Biomater. Sci. Polym. Ed., 2001, 12 (1), 21.
    • (2001) J. Biomater , vol.12 , Issue.1 , pp. 21
    • Wu, X.S.1    Wang, N.2
  • 222
    • 0030033719 scopus 로고    scopus 로고
    • Mechanisms of polymer degradation and erosion
    • Gopferich, A. Mechanisms of polymer degradation and erosion. Biomaterials, 1996, 17 (2), 103.
    • (1996) Biomaterials , vol.17 , Issue.2 , pp. 103
    • Gopferich, A.1
  • 223
    • 0003156346 scopus 로고
    • Wise, D.L, Trantolot, D.J, Altobelli, D.E, Yaszemski, M.J, Gresser, J.D, Schwartz, E.R, Ed, Marcel Dekker: New York
    • Wu, S.W. In Encyclopedic handbook of biomaterials and bioengineering, Part A: Materials; Wise, D.L.; Trantolot, D.J.; Altobelli, D.E.; Yaszemski, M.J.; Gresser, J.D.; Schwartz, E.R., Ed.; Marcel Dekker: New York, 1995, Vol. 2, pp. 1015.
    • (1995) Encyclopedic handbook of biomaterials and bioengineering, Part A: Materials , vol.2 , pp. 1015
    • Wu, S.W.1
  • 224
    • 0028564916 scopus 로고
    • Biodegradation of PLA/GA polymers: Increasing complexity
    • Vert, M.; Mauduit, J.; Li, S. Biodegradation of PLA/GA polymers: increasing complexity. Biomaterials, 1994, 15 (15), 1209.
    • (1994) Biomaterials , vol.15 , Issue.15 , pp. 1209
    • Vert, M.1    Mauduit, J.2    Li, S.3
  • 225
    • 0029256583 scopus 로고
    • Hydrolytic degradation of devices based on poly(DL-lactic acid) size-dependence
    • Grizzi, I.; Garreau, H.; Li, S.; Vert, M. Hydrolytic degradation of devices based on poly(DL-lactic acid) size-dependence. Biomaterials, 1995, 16 (4), 305.
    • (1995) Biomaterials , vol.16 , Issue.4 , pp. 305
    • Grizzi, I.1    Garreau, H.2    Li, S.3    Vert, M.4
  • 227
    • 0032765726 scopus 로고    scopus 로고
    • Influence of formulation parameters on the characteristics of poly(D, L-lactide-coglycolide) microspheres containing poly(L-lysine) complexed plasmid DNA
    • Capan, Y.; Woo, B.H.; Gebrekidan, S.; Ahmed, S.; DeLuca, P.P. Influence of formulation parameters on the characteristics of poly(D, L-lactide-coglycolide) microspheres containing poly(L-lysine) complexed plasmid DNA. J. Control. Release, 1999, 60 (2-3), 279.
    • (1999) J. Control. Release , vol.60 , Issue.2-3 , pp. 279
    • Capan, Y.1    Woo, B.H.2    Gebrekidan, S.3    Ahmed, S.4    DeLuca, P.P.5
  • 228
    • 1242337281 scopus 로고    scopus 로고
    • Critical determinants in PLGA/PLA nanoparticle-mediated gene expression
    • Prabha, S.; Labhasetwar, V. Critical determinants in PLGA/PLA nanoparticle-mediated gene expression. Pharm. Res., 2004, 21 (2), 354.
    • (2004) Pharm. Res , vol.21 , Issue.2 , pp. 354
    • Prabha, S.1    Labhasetwar, V.2
  • 231
    • 17344362958 scopus 로고    scopus 로고
    • Leong Controlled Gene Delivery by DNA-Gelatin Nanospheres
    • Truong-Le, V.L., Thomas August, and Kam W. Leong Controlled Gene Delivery by DNA-Gelatin Nanospheres. Hum. Gene Ther., 1998, 9 1709.
    • (1998) Hum. Gene Ther , vol.9 , pp. 1709
    • Truong-Le, V.L.1    August, T.2    Kam, W.3
  • 234
  • 236
    • 0035823546 scopus 로고    scopus 로고
    • Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes
    • Ruponen, M.; Ronkko, S.; Honkakoski, P.; Pelkonen, J.; Tammi, M.; Urtti, A. Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes. J. Biol. Chem., 2001, 276 (36), 33875.
    • (2001) J. Biol. Chem , vol.276 , Issue.36 , pp. 33875
    • Ruponen, M.1    Ronkko, S.2    Honkakoski, P.3    Pelkonen, J.4    Tammi, M.5    Urtti, A.6
  • 237
    • 36348995376 scopus 로고    scopus 로고
    • Subcutaneous peripheral injection of cationized gelatin/DNA polyplexes as a platform for non-viral gene transfer to sensory neurons
    • Thakor, D.; Spigelman, I.; Tabata, Y.; Nishimura, I. Subcutaneous peripheral injection of cationized gelatin/DNA polyplexes as a platform for non-viral gene transfer to sensory neurons. Mol. Ther., 2007, 15 (12), 2124.
    • (2007) Mol. Ther , vol.15 , Issue.12 , pp. 2124
    • Thakor, D.1    Spigelman, I.2    Tabata, Y.3    Nishimura, I.4
  • 238
    • 0034092776 scopus 로고    scopus 로고
    • Gelatin nanoparticles by two step desolvation - a new preparation method, surface modifications and cell uptake
    • Coester, C.J.; Langer, K.; van Briesen, H.; Kreuter, J. Gelatin nanoparticles by two step desolvation - a new preparation method, surface modifications and cell uptake. J. Microencapsul., 2000, 17 (2), 187.
    • (2000) J. Microencapsul , vol.17 , Issue.2 , pp. 187
    • Coester, C.J.1    Langer, K.2    van Briesen, H.3    Kreuter, J.4
  • 239
    • 0034658305 scopus 로고    scopus 로고
    • Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan
    • Lim, S.T.; Martin, G.P.; Berry, D.J.; Brown, M.B. Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan. J. Control. Release, 2000, 66 (2-3), 281.
    • (2000) J. Control. Release , vol.66 , Issue.2-3 , pp. 281
    • Lim, S.T.1    Martin, G.P.2    Berry, D.J.3    Brown, M.B.4
  • 240
    • 0032824432 scopus 로고    scopus 로고
    • Gene transfection using biodegradable nanospheres: Results in tissue culture and rat osteotomy model
    • Labhasetwar, V.; Bonadio, J.; Goldstein, S.A.; Levy, R.J. Gene transfection using biodegradable nanospheres: results in tissue culture and rat osteotomy model. Colloids Surf. B Biointerfaces, 1999, 16 (1-4), 281.
    • (1999) Colloids Surf. B Biointerfaces , vol.16 , Issue.1-4 , pp. 281
    • Labhasetwar, V.1    Bonadio, J.2    Goldstein, S.A.3    Levy, R.J.4
  • 241
    • 0035838366 scopus 로고    scopus 로고
    • Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA
    • Perez, C.; Sanchez, A.; Putnam, D.; Ting, D.; Langer, R.; Alonso, M.J. Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA. J. Control. Release, 2001, 75 (1-2), 211.
    • (2001) J. Control. Release , vol.75 , Issue.1-2 , pp. 211
    • Perez, C.1    Sanchez, A.2    Putnam, D.3    Ting, D.4    Langer, R.5    Alonso, M.J.6
  • 242
    • 0034996764 scopus 로고    scopus 로고
    • Long-circulating and target-specific nanoparticles: Theory to practice
    • Moghimi, S.M.; Hunter, A.C.; Murray, J.C. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev., 2001, 53(2), 283.
    • (2001) Pharmacol. Rev , vol.53 , Issue.2 , pp. 283
    • Moghimi, S.M.1    Hunter, A.C.2    Murray, J.C.3
  • 243
    • 0035936975 scopus 로고    scopus 로고
    • Drug delivery in poly(lactide-coglycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: In vitro characterisation and in vivo evaluation
    • Redhead, H.M.; Davis, S.S.; Illum, L. Drug delivery in poly(lactide-coglycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation. J. Control. Release, 2001, 70(3), 353.
    • (2001) J. Control. Release , vol.70 , Issue.3 , pp. 353
    • Redhead, H.M.1    Davis, S.S.2    Illum, L.3
  • 244
    • 0031469673 scopus 로고    scopus 로고
    • The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent
    • Desai, M.P.; Labhasetwar, V.; Walter, E.; Levy, R.J.; Amidon, G.L. The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm. Res., 1997, 14 (11), 1568.
    • (1997) Pharm. Res , vol.14 , Issue.11 , pp. 1568
    • Desai, M.P.1    Labhasetwar, V.2    Walter, E.3    Levy, R.J.4    Amidon, G.L.5
  • 245
    • 0030471901 scopus 로고    scopus 로고
    • Gastrointestinal uptake of biodegradable microparticles: Effect of particle size
    • Desai, M.P.; Labhasetwar, V.; Amidon, G.L.; Levy, R.J. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res., 1996, 13 (12), 1838.
    • (1996) Pharm. Res , vol.13 , Issue.12 , pp. 1838
    • Desai, M.P.1    Labhasetwar, V.2    Amidon, G.L.3    Levy, R.J.4
  • 246
    • 0037026269 scopus 로고    scopus 로고
    • Size-dependency of nanoparticle-mediated gene transfection: Studies with fractionated nanoparticles
    • Prabha, S.; Zhou, W.Z.; Panyam, J.; Labhasetwar, V. Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles. Int. J. Pharm., 2002, 244 (1-2), 105.
    • (2002) Int. J. Pharm , vol.244 , Issue.1-2 , pp. 105
    • Prabha, S.1    Zhou, W.Z.2    Panyam, J.3    Labhasetwar, V.4
  • 247
    • 0037331856 scopus 로고    scopus 로고
    • Dynamics of endocytosis and exocytosis of poly(D,L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells
    • Panyam, J.; Labhasetwar, V. Dynamics of endocytosis and exocytosis of poly(D,L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells. Pharm. Res., 2003, 20 (2), 212.
    • (2003) Pharm. Res , vol.20 , Issue.2 , pp. 212
    • Panyam, J.1    Labhasetwar, V.2
  • 248
    • 0035848402 scopus 로고    scopus 로고
    • In vitro uptake of polystyrene microspheres: Effect of particle size, cell line and cell density
    • Zauner, W.; Farrow, N.A.; Haines, A.M. In vitro uptake of polystyrene microspheres: effect of particle size, cell line and cell density. J. Control. Release, 2001, 71 (1), 39.
    • (2001) J. Control. Release , vol.71 , Issue.1 , pp. 39
    • Zauner, W.1    Farrow, N.A.2    Haines, A.M.3
  • 249
    • 0031904113 scopus 로고    scopus 로고
    • Recent advances in pulmonary drug delivery using large, porous inhaled particles
    • Edwards, D.A.; Ben-Jebria, A.; Langer, R. Recent advances in pulmonary drug delivery using large, porous inhaled particles. J. Appl. Physiol., 1998, 85 (2), 379.
    • (1998) J. Appl. Physiol , vol.85 , Issue.2 , pp. 379
    • Edwards, D.A.1    Ben-Jebria, A.2    Langer, R.3
  • 250
    • 0037148662 scopus 로고    scopus 로고
    • Characterization of nanoparticle uptake by endothelial cells
    • Davda, J.; Labhasetwar, V. Characterization of nanoparticle uptake by endothelial cells. Int. J. Pharm., 2002, 233 (1-2), 51.
    • (2002) Int. J. Pharm , vol.233 , Issue.1-2 , pp. 51
    • Davda, J.1    Labhasetwar, V.2
  • 251
    • 0343067072 scopus 로고    scopus 로고
    • Wattiaux, R.; Laurent, N.; Wattiaux-De Coninck, S.; Jadot, M. Endosomes, lysosomes: their implication in gene transfer. Adv. Drug Deliv. Rev., 2000, 41 (2), 201.
    • Wattiaux, R.; Laurent, N.; Wattiaux-De Coninck, S.; Jadot, M. Endosomes, lysosomes: their implication in gene transfer. Adv. Drug Deliv. Rev., 2000, 41 (2), 201.
  • 252
    • 0036324712 scopus 로고    scopus 로고
    • Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: Implications for drug and gene delivery
    • Panyam, J.; Zhou, W.Z.; Prabha, S.; Sahoo, S.K.; Labhasetwar, V. Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery. FASEB J., 2002, 16 (10), 1217.
    • (2002) FASEB J , vol.16 , Issue.10 , pp. 1217
    • Panyam, J.1    Zhou, W.Z.2    Prabha, S.3    Sahoo, S.K.4    Labhasetwar, V.5
  • 253
    • 0001585910 scopus 로고
    • The colloidal properties of surfactant-free biodegradable nanopsheres from poly(beta-malic acid-co-benzyl malate)s and poly(lactide acid-co-glycolide)
    • Stolnik, S.; Garnett, M.C.; Davies, M.C.; Illum, L.; Bousta, M.; Vert, M.; Davis, S.S. The colloidal properties of surfactant-free biodegradable nanopsheres from poly(beta-malic acid-co-benzyl malate)s and poly(lactide acid-co-glycolide). Colloids Surf. A: Physicochem. Eng. Aspects, 1995, 97, 235.
    • (1995) Colloids Surf. A: Physicochem. Eng. Aspects , vol.97 , pp. 235
    • Stolnik, S.1    Garnett, M.C.2    Davies, M.C.3    Illum, L.4    Bousta, M.5    Vert, M.6    Davis, S.S.7
  • 254
    • 0023014049 scopus 로고
    • Transfer of protons from bulk solution to the surface of poly(L-lactide) microcapsules
    • Makino, K.; Ohshima, H.; Kondo, T. Transfer of protons from bulk solution to the surface of poly(L-lactide) microcapsules. J. Microencapsul., 1986, 3 (3), 195.
    • (1986) J. Microencapsul , vol.3 , Issue.3 , pp. 195
    • Makino, K.1    Ohshima, H.2    Kondo, T.3
  • 255
    • 0024442942 scopus 로고
    • Temperature effect on endocytosis and exocytosis by rabbit alveolar macrophages
    • Tomoda, H.; Kishimoto, Y.; Lee, Y.C. Temperature effect on endocytosis and exocytosis by rabbit alveolar macrophages. J. Biol. Chem., 1989, 264 (26), 15445.
    • (1989) J. Biol. Chem , vol.264 , Issue.26 , pp. 15445
    • Tomoda, H.1    Kishimoto, Y.2    Lee, Y.C.3
  • 256
    • 0034006495 scopus 로고    scopus 로고
    • Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres
    • Fu, K.; Pack, D.W.; Klibanov, A.M.; Langer, R. Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm. Res., 2000, 17 (1), 100.
    • (2000) Pharm. Res , vol.17 , Issue.1 , pp. 100
    • Fu, K.1    Pack, D.W.2    Klibanov, A.M.3    Langer, R.4
  • 257
    • 0034657718 scopus 로고    scopus 로고
    • Formulation of poly(D,L-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery
    • Tinsley-Bown, A.M.; Fretwell, R.; Dowsett, A.B.; Davis, S.L.; Farrar, G.H. Formulation of poly(D,L-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery. J. Control. Release, 2000, 66 (2-3), 229.
    • (2000) J. Control. Release , vol.66 , Issue.2-3 , pp. 229
    • Tinsley-Bown, A.M.1    Fretwell, R.2    Dowsett, A.B.3    Davis, S.L.4    Farrar, G.H.5
  • 259
    • 14044266772 scopus 로고    scopus 로고
    • PLGA:poloxamer and PLGA:poloxamine blend nanoparticles: New carriers for gene delivery
    • Csaba, N.; Caamano, P.; Sanchez, A.; Dominguez, F.; Alonso, M.J. PLGA:poloxamer and PLGA:poloxamine blend nanoparticles: new carriers for gene delivery. Biomacromolecules, 2005, 6 (1), 271.
    • (2005) Biomacromolecules , vol.6 , Issue.1 , pp. 271
    • Csaba, N.1    Caamano, P.2    Sanchez, A.3    Dominguez, F.4    Alonso, M.J.5
  • 260
    • 0032949618 scopus 로고    scopus 로고
    • PLGA microspheres containing plasmid DNA: Preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization
    • Ando, S.; Putnam, D.; Pack, D.W.; Langer, R. PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization. J. Pharm. Sci., 1999, 88 (1), 126.
    • (1999) J. Pharm. Sci , vol.88 , Issue.1 , pp. 126
    • Ando, S.1    Putnam, D.2    Pack, D.W.3    Langer, R.4
  • 261
    • 0032921913 scopus 로고    scopus 로고
    • Encapsulation of plasmid DNA in biodegradable poly(D, L-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery
    • Wang, D.; Robinson, D.R.; Kwon, G.S.; Samuel, J. Encapsulation of plasmid DNA in biodegradable poly(D, L-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery. J. Control. Release, 1999, 57 (1), 9.
    • (1999) J. Control. Release , vol.57 , Issue.1 , pp. 9
    • Wang, D.1    Robinson, D.R.2    Kwon, G.S.3    Samuel, J.4
  • 262
    • 33744770265 scopus 로고    scopus 로고
    • Effect of various formulation parameters on the properties of polymeric nanoparticles prepared by multiple emulsion method
    • Rizkalla, N.; Range, C.; Lacasse, F.X.; Hildgen, P. Effect of various formulation parameters on the properties of polymeric nanoparticles prepared by multiple emulsion method. J. Microencapsul., 2006, 23 (1), 39.
    • (2006) J. Microencapsul , vol.23 , Issue.1 , pp. 39
    • Rizkalla, N.1    Range, C.2    Lacasse, F.X.3    Hildgen, P.4
  • 263
    • 0037130209 scopus 로고    scopus 로고
    • Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake
    • Sahoo, S.K.; Panyam, J.; Prabha, S.; Labhasetwar, V. Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. J. Control. Release, 2002, 82 (1), 105.
    • (2002) J. Control. Release , vol.82 , Issue.1 , pp. 105
    • Sahoo, S.K.1    Panyam, J.2    Prabha, S.3    Labhasetwar, V.4
  • 264
    • 0347761356 scopus 로고    scopus 로고
    • Preparation and characterization of cationic PLGA nanospheres as DNA carriers
    • Ravi Kumar, M.N.; Bakowsky, U.; Lehr, C.M. Preparation and characterization of cationic PLGA nanospheres as DNA carriers. Biomaterials, 2004, 25 (10), 1771.
    • (2004) Biomaterials , vol.25 , Issue.10 , pp. 1771
    • Ravi Kumar, M.N.1    Bakowsky, U.2    Lehr, C.M.3
  • 265
    • 0029891916 scopus 로고    scopus 로고
    • Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle
    • Mumper, R.J.; Duguid, J.G.; Anwer, K.; Barron, M.K.; Nitta, H.; Rolland, A.P. Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle. Pharm. Res., 1996, 13 (5), 701.
    • (1996) Pharm. Res , vol.13 , Issue.5 , pp. 701
    • Mumper, R.J.1    Duguid, J.G.2    Anwer, K.3    Barron, M.K.4    Nitta, H.5    Rolland, A.P.6
  • 266
    • 0032902891 scopus 로고    scopus 로고
    • Preparation and characterization of poly (D,L-lactide-co-glycolide) microspheres for controlled release of poly(L-lysine) complexed plasmid DNA
    • Capan, Y.; Woo, B.H.; Gebrekidan, S.; Ahmed, S.; DeLuca, P.P. Preparation and characterization of poly (D,L-lactide-co-glycolide) microspheres for controlled release of poly(L-lysine) complexed plasmid DNA. Pharm. Res., 1999, 16 (4), 509.
    • (1999) Pharm. Res , vol.16 , Issue.4 , pp. 509
    • Capan, Y.1    Woo, B.H.2    Gebrekidan, S.3    Ahmed, S.4    DeLuca, P.P.5
  • 268
    • 20444488293 scopus 로고    scopus 로고
    • Physicochemical characterization of poly(L-lactic acid) and poly(D,L-lactide-co-glycolide) nanoparticles with polyethylenimine as gene delivery carrier
    • Kim, I.S.; Lee, S.K.; Park, Y.M.; Lee, Y.B.; Shin, S.C.; Lee, K.C.; Oh, I.J. Physicochemical characterization of poly(L-lactic acid) and poly(D,L-lactide-co-glycolide) nanoparticles with polyethylenimine as gene delivery carrier. Int. J. Pharm., 2005, 298 (1), 255.
    • (2005) Int. J. Pharm , vol.298 , Issue.1 , pp. 255
    • Kim, I.S.1    Lee, S.K.2    Park, Y.M.3    Lee, Y.B.4    Shin, S.C.5    Lee, K.C.6    Oh, I.J.7
  • 269
    • 11244286566 scopus 로고    scopus 로고
    • Cationic poly(lactide-co-glycolide) nanoparticles as efficient in vivo gene transfection agents
    • Kumar, M.N.; Mohapatra, S.S.; Kong, X.; Jena, P.K.; Bakowsky, U.; Lehr, C.M. Cationic poly(lactide-co-glycolide) nanoparticles as efficient in vivo gene transfection agents. J. Nanosci. Nanotechnol., 2004, 4 (8), 990.
    • (2004) J. Nanosci. Nanotechnol , vol.4 , Issue.8 , pp. 990
    • Kumar, M.N.1    Mohapatra, S.S.2    Kong, X.3    Jena, P.K.4    Bakowsky, U.5    Lehr, C.M.6
  • 270
    • 0034681126 scopus 로고    scopus 로고
    • Cationic microparticles: A potent delivery system for DNA vaccines
    • Singh, M.; Briones, M.; Ott, G.; O'Hagan, D. Cationic microparticles: A potent delivery system for DNA vaccines. Proc. Natl. Acad. Sci. USA, 2000, 97 (2), 811.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , Issue.2 , pp. 811
    • Singh, M.1    Briones, M.2    Ott, G.3    O'Hagan, D.4
  • 271
    • 21344442165 scopus 로고    scopus 로고
    • Cationic PLA nanoparticles for DNA delivery: Comparison of three surface polycations for DNA binding, protection and transfection properties
    • Munier, S.; Messai, I.; Delair, T.; Verrier, B.; Ataman-Onal, Y. Cationic PLA nanoparticles for DNA delivery: comparison of three surface polycations for DNA binding, protection and transfection properties. Colloids Surf. B Biointerfaces, 2005, 43 (3-4), 163.
    • (2005) Colloids Surf. B Biointerfaces , vol.43 , Issue.3-4 , pp. 163
    • Munier, S.1    Messai, I.2    Delair, T.3    Verrier, B.4    Ataman-Onal, Y.5
  • 272
    • 19544389448 scopus 로고    scopus 로고
    • Cationic microparticles consisting of poly(lactide-coglycolide) and polyethylenimine as carriers systems for parental DNA vaccination
    • Oster, C.G.; Kim, N.; Grode, L.; Barbu-Tudoran, L.; Schaper, A.K.; Kaufmann, S.H.; Kissel, T. Cationic microparticles consisting of poly(lactide-coglycolide) and polyethylenimine as carriers systems for parental DNA vaccination. J. Control. Release, 2005, 104 (2), 359.
    • (2005) J. Control. Release , vol.104 , Issue.2 , pp. 359
    • Oster, C.G.1    Kim, N.2    Grode, L.3    Barbu-Tudoran, L.4    Schaper, A.K.5    Kaufmann, S.H.6    Kissel, T.7
  • 273
    • 1842784818 scopus 로고    scopus 로고
    • Charged polylactide co-glycolide microparticles as antigen delivery systems
    • Singh, M.; Kazzaz, J.; Ugozzoli, M.; Chesko, J.; O'Hagan, D.T. Charged polylactide co-glycolide microparticles as antigen delivery systems. Expert Opin. Biol. Ther., 2004, 4 (4), 483.
    • (2004) Expert Opin. Biol. Ther , vol.4 , Issue.4 , pp. 483
    • Singh, M.1    Kazzaz, J.2    Ugozzoli, M.3    Chesko, J.4    O'Hagan, D.T.5
  • 276
    • 0034770990 scopus 로고    scopus 로고
    • Cationic microparticles are an effective delivery system for immune stimulatory cpG DNA
    • Singh, M.; Ott, G.; Kazzaz, J.; Ugozzoli, M.; Briones, M.; Donnelly, J.; O'Hagan, D.T. Cationic microparticles are an effective delivery system for immune stimulatory cpG DNA. Pharm. Res., 2001, 18 (10), 1476.
    • (2001) Pharm. Res , vol.18 , Issue.10 , pp. 1476
    • Singh, M.1    Ott, G.2    Kazzaz, J.3    Ugozzoli, M.4    Briones, M.5    Donnelly, J.6    O'Hagan, D.T.7
  • 277
    • 4143143002 scopus 로고    scopus 로고
    • Sustained delivery and expression of plasmid DNA based on biodegradable polyester, poly(D,L-lactide-co-4-hydroxy-L-proline)
    • Li, Z.; Huang, L. Sustained delivery and expression of plasmid DNA based on biodegradable polyester, poly(D,L-lactide-co-4-hydroxy-L-proline). J. Control. Release, 2004, 98 (3), 437.
    • (2004) J. Control. Release , vol.98 , Issue.3 , pp. 437
    • Li, Z.1    Huang, L.2
  • 278
    • 0033000907 scopus 로고    scopus 로고
    • New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material: The Minipellet
    • Ochiya, T.; Takahama, Y.; Nagahara, S.; Sumita, Y.; Hisada, A.; Itoh, H.; Nagai, Y.; Terada, M. New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material: the Minipellet. Nat. Med., 1999, 5 (6), 707.
    • (1999) Nat. Med , vol.5 , Issue.6 , pp. 707
    • Ochiya, T.1    Takahama, Y.2    Nagahara, S.3    Sumita, Y.4    Hisada, A.5    Itoh, H.6    Nagai, Y.7    Terada, M.8
  • 281
    • 0034879346 scopus 로고    scopus 로고
    • Gene delivery of vaccines for infectious disease
    • Clark, K.R.; Johnson, P.R. Gene delivery of vaccines for infectious disease. Curr. Opin. Mol. Ther., 2001, 3 (4), 375.
    • (2001) Curr. Opin. Mol. Ther , vol.3 , Issue.4 , pp. 375
    • Clark, K.R.1    Johnson, P.R.2
  • 282
    • 0029973865 scopus 로고    scopus 로고
    • Tissue engineering using synthetic extracellular matrices
    • Putnam, A.J.; Mooney, D.J. Tissue engineering using synthetic extracellular matrices. Nat. Med., 1996, 2 (7), 824.
    • (1996) Nat. Med , vol.2 , Issue.7 , pp. 824
    • Putnam, A.J.1    Mooney, D.J.2
  • 283
    • 24344506666 scopus 로고    scopus 로고
    • Bioengineered tissues: The science, the technology, and the industry
    • Ahsan, T.; Nerem, R.M. Bioengineered tissues: the science, the technology, and the industry. Orthod. Craniofac. Res., 2005, 8 (3), 134.
    • (2005) Orthod. Craniofac. Res , vol.8 , Issue.3 , pp. 134
    • Ahsan, T.1    Nerem, R.M.2
  • 285
    • 13544250805 scopus 로고    scopus 로고
    • Gene delivery from polymer scaffolds for tissue engineering
    • Jang, J.H.; Houchin, T.L.; Shea, L.D. Gene delivery from polymer scaffolds for tissue engineering. Expert Rev. Med. Devices, 2004, 1 (1), 127.
    • (2004) Expert Rev. Med. Devices , vol.1 , Issue.1 , pp. 127
    • Jang, J.H.1    Houchin, T.L.2    Shea, L.D.3
  • 286
    • 0033553126 scopus 로고    scopus 로고
    • Mitosis enhances transgene expression of plasmid delivered by cationic liposomes
    • Tseng, W.C.; Haselton, F.R.; Giorgio, T.D. Mitosis enhances transgene expression of plasmid delivered by cationic liposomes. Biochim. Biophys. Acta, 1999, 1445 (1), 53.
    • (1999) Biochim. Biophys. Acta , vol.1445 , Issue.1 , pp. 53
    • Tseng, W.C.1    Haselton, F.R.2    Giorgio, T.D.3
  • 287
    • 0033856380 scopus 로고    scopus 로고
    • Tissue engineering via local gene delivery
    • Bonadio, J. Tissue engineering via local gene delivery. J. Mol. Med., 2000, 78 (6), 303.
    • (2000) J. Mol. Med , vol.78 , Issue.6 , pp. 303
    • Bonadio, J.1
  • 288
  • 289
    • 0033202432 scopus 로고    scopus 로고
    • Controlled delivery of inductive proteins, plasmid DNA and cells from tissue engineering matrices
    • Murphy, W.L.; Mooney, D.J. Controlled delivery of inductive proteins, plasmid DNA and cells from tissue engineering matrices. J. Periodontal Res., 1999, 34 (7), 413.
    • (1999) J. Periodontal Res , vol.34 , Issue.7 , pp. 413
    • Murphy, W.L.1    Mooney, D.J.2
  • 291
    • 0032404328 scopus 로고    scopus 로고
    • Development of biocompatible synthetic extracellular matrices for tissue engineering
    • Kim, B.S.; Mooney, D.J. Development of biocompatible synthetic extracellular matrices for tissue engineering. Trends Biotechnol., 1998, 16 (5), 224.
    • (1998) Trends Biotechnol , vol.16 , Issue.5 , pp. 224
    • Kim, B.S.1    Mooney, D.J.2
  • 292
    • 23844480941 scopus 로고    scopus 로고
    • Plasmid delivery in vivo from porous tissue-engineering scaffolds: Transgene expression and cellular transfection
    • Jang, J.H.; Rives, C.B.; Shea, L.D. Plasmid delivery in vivo from porous tissue-engineering scaffolds: transgene expression and cellular transfection. Mol. Ther., 2005, 12 (3), 475.
    • (2005) Mol. Ther , vol.12 , Issue.3 , pp. 475
    • Jang, J.H.1    Rives, C.B.2    Shea, L.D.3
  • 293
    • 0033021062 scopus 로고    scopus 로고
    • Localized, direct plasmid gene delivery in vivo: Prolonged therapy results in reproducible tissue regeneration
    • Bonadio, J.; Smiley, E.; Patil, P.; Goldstein, S. Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nat. Med., 1999, 5 (7), 753.
    • (1999) Nat. Med , vol.5 , Issue.7 , pp. 753
    • Bonadio, J.1    Smiley, E.2    Patil, P.3    Goldstein, S.4
  • 295
    • 0033780547 scopus 로고    scopus 로고
    • Collagen-embedded platelet-derived growth factor DNA plasmid promotes wound healing in a dermal ulcer model
    • Tyrone, J.W.; Mogford, J.E.; Chandler, L.A.; Ma, C.; Xia, Y.; Pierce, G.F.; Mustoe, T.A. Collagen-embedded platelet-derived growth factor DNA plasmid promotes wound healing in a dermal ulcer model. J. Surg. Res., 2000, 93 (2), 230.
    • (2000) J. Surg. Res , vol.93 , Issue.2 , pp. 230
    • Tyrone, J.W.1    Mogford, J.E.2    Chandler, L.A.3    Ma, C.4    Xia, Y.5    Pierce, G.F.6    Mustoe, T.A.7
  • 296
    • 33645942083 scopus 로고    scopus 로고
    • Surface adsorption of DNA to tissue engineering scaffolds for efficient gene delivery
    • Jang, J.H.; Bengali, Z.; Houchin, T.L.; Shea, L.D. Surface adsorption of DNA to tissue engineering scaffolds for efficient gene delivery. J. Biomed. Mater. Res. A, 2006, 77 (1), 50.
    • (2006) J. Biomed. Mater. Res. A , vol.77 , Issue.1 , pp. 50
    • Jang, J.H.1    Bengali, Z.2    Houchin, T.L.3    Shea, L.D.4
  • 297
    • 0036000157 scopus 로고    scopus 로고
    • Surface-tethered DNA complexes for enhanced gene delivery
    • Segura, T.; Shea, L.D. Surface-tethered DNA complexes for enhanced gene delivery. Bioconjug. Chem., 2002, 13 (3), 621.
    • (2002) Bioconjug. Chem , vol.13 , Issue.3 , pp. 621
    • Segura, T.1    Shea, L.D.2
  • 298
    • 0036490227 scopus 로고    scopus 로고
    • Building drug delivery into tissue engineering
    • Saltzman, W.M.; Olbricht, W.L. Building drug delivery into tissue engineering. Nat. Rev. Drug Discov., 2002, 1 (3), 177.
    • (2002) Nat. Rev. Drug Discov , vol.1 , Issue.3 , pp. 177
    • Saltzman, W.M.1    Olbricht, W.L.2
  • 300
    • 0034004284 scopus 로고    scopus 로고
    • Application of membrane-based dendrimer/ DNA complexes for solid phase transfection in vitro and in vivo
    • Bielinska, A.U.; Yen, A.; Wu, H.L.; Zahos, K.M.; Sun, R.; Weiner, N.D.; Baker, J.R., Jr.; Roessler, B.J. Application of membrane-based dendrimer/ DNA complexes for solid phase transfection in vitro and in vivo. Biomaterials, 2000, 21 (9), 877.
    • (2000) Biomaterials , vol.21 , Issue.9 , pp. 877
    • Bielinska, A.U.1    Yen, A.2    Wu, H.L.3    Zahos, K.M.4    Sun, R.5    Weiner, N.D.6    Baker Jr., J.R.7    Roessler, B.J.8
  • 301
    • 0041768521 scopus 로고    scopus 로고
    • Nonviral vector loaded collagen sponges for sustained gene delivery in vitro and in vivo
    • Scherer, F.; Schillinger, U.; Putz, U.; Stemberger, A.; Plank, C. Nonviral vector loaded collagen sponges for sustained gene delivery in vitro and in vivo. J. Gene Med., 2002, 4 (6), 634.
    • (2002) J. Gene Med , vol.4 , Issue.6 , pp. 634
    • Scherer, F.1    Schillinger, U.2    Putz, U.3    Stemberger, A.4    Plank, C.5
  • 302
    • 0033912738 scopus 로고    scopus 로고
    • Protective copolymers for nonviral gene vectors: Synthesis, vector characterization and application in gene delivery
    • Finsinger, D.; Remy, J.S.; Erbacher, P.; Koch, C.; Plank, C. Protective copolymers for nonviral gene vectors: synthesis, vector characterization and application in gene delivery. Gene Ther., 2000, 7 (14), 1183.
    • (2000) Gene Ther , vol.7 , Issue.14 , pp. 1183
    • Finsinger, D.1    Remy, J.S.2    Erbacher, P.3    Koch, C.4    Plank, C.5
  • 303
    • 7444231517 scopus 로고    scopus 로고
    • Delivery of a vector encoding mouse hyaluronan synthase 2 via a crosslinked hyaluronan film
    • Kim, A.P.; Yellen, P.; Yun, Y.H.; Azeloglu, E.; Chen, W. Delivery of a vector encoding mouse hyaluronan synthase 2 via a crosslinked hyaluronan film. Biomaterials, 2005, 26 (13), 1585.
    • (2005) Biomaterials , vol.26 , Issue.13 , pp. 1585
    • Kim, A.P.1    Yellen, P.2    Yun, Y.H.3    Azeloglu, E.4    Chen, W.5
  • 304
    • 0242352521 scopus 로고    scopus 로고
    • Substrate-mediated DNA delivery: Role of the cationic polymer structure and extent of modification
    • Segura, T.; Volk, M.J.; Shea, L.D. Substrate-mediated DNA delivery: role of the cationic polymer structure and extent of modification. J. Control. Release, 2003, 93 (1), 69.
    • (2003) J. Control. Release , vol.93 , Issue.1 , pp. 69
    • Segura, T.1    Volk, M.J.2    Shea, L.D.3
  • 305
    • 17644377327 scopus 로고    scopus 로고
    • Long-term in vivo gene expression via delivery of PEI-DNA condensates from porous polymer scaffolds
    • Huang, Y.C.; Riddle, K.; Rice, K.G.; Mooney, D.J. Long-term in vivo gene expression via delivery of PEI-DNA condensates from porous polymer scaffolds. Hum. Gene Ther., 2005, 16 (5), 609.
    • (2005) Hum. Gene Ther , vol.16 , Issue.5 , pp. 609
    • Huang, Y.C.1    Riddle, K.2    Rice, K.G.3    Mooney, D.J.4
  • 306
    • 0037426720 scopus 로고    scopus 로고
    • Controllable delivery of non-viral DNA from porous scaffolds
    • Jang, J.H.; Shea, L.D. Controllable delivery of non-viral DNA from porous scaffolds. J. Control. Release, 2003, 86 (1), 157.
    • (2003) J. Control. Release , vol.86 , Issue.1 , pp. 157
    • Jang, J.H.1    Shea, L.D.2
  • 307
    • 0034782511 scopus 로고    scopus 로고
    • Polymeric delivery of proteins and plasmid DNA for tissue engineering and gene therapy
    • Richardson, T.P.; Murphy, W.L.; Mooney, D.J. Polymeric delivery of proteins and plasmid DNA for tissue engineering and gene therapy. Crit. Rev. Eukaryot. Gene Expr., 2001, 11 (1-3), 47.
    • (2001) Crit. Rev. Eukaryot. Gene Expr , vol.11 , Issue.1-3 , pp. 47
    • Richardson, T.P.1    Murphy, W.L.2    Mooney, D.J.3
  • 308
    • 0032488267 scopus 로고    scopus 로고
    • Open pore biodegradable matrices formed with gas foaming
    • Harris, L.D.; Kim, B.S.; Mooney, D.J. Open pore biodegradable matrices formed with gas foaming. J. Biomed. Mater. Res., 1998, 42 (3), 396.
    • (1998) J. Biomed. Mater. Res , vol.42 , Issue.3 , pp. 396
    • Harris, L.D.1    Kim, B.S.2    Mooney, D.J.3
  • 310
    • 65749101416 scopus 로고    scopus 로고
    • Chandrashekar; Bhagya, L.; Zhou; Mingxing; Jarr; M., E.; Dunn; Richard, L. U.S. Patent 6,630,155, 2003.
    • Chandrashekar; Bhagya, L.; Zhou; Mingxing; Jarr; M., E.; Dunn; Richard, L. U.S. Patent 6,630,155, 2003.
  • 312
    • 0034110737 scopus 로고    scopus 로고
    • Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins
    • Eliaz, R.E.; Kost, J. Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins. J. Biomed. Mater. Res., 2000, 50 (3), 388.
    • (2000) J. Biomed. Mater. Res , vol.50 , Issue.3 , pp. 388
    • Eliaz, R.E.1    Kost, J.2
  • 313
    • 0034467890 scopus 로고    scopus 로고
    • Delivery of soluble tumor necrosis factor receptor from in-situ forming PLGA implants: In-vivo
    • Eliaz, R.E.; Wallach, D.; Kost, J. Delivery of soluble tumor necrosis factor receptor from in-situ forming PLGA implants: in-vivo. Pharm. Res., 2000, 17 (12), 1546.
    • (2000) Pharm. Res , vol.17 , Issue.12 , pp. 1546
    • Eliaz, R.E.1    Wallach, D.2    Kost, J.3
  • 314
    • 0029789140 scopus 로고    scopus 로고
    • Biodegradable injectable implant systems for long term drug delivery using poly (lactic-co-glycolic) acid copolymers
    • Chandrashekar, G.; Udupa, N. Biodegradable injectable implant systems for long term drug delivery using poly (lactic-co-glycolic) acid copolymers. J. Pharm. Pharmacol., 1996, 48 (7), 669.
    • (1996) J. Pharm. Pharmacol , vol.48 , Issue.7 , pp. 669
    • Chandrashekar, G.1    Udupa, N.2
  • 316
    • 65749098515 scopus 로고    scopus 로고
    • U.S. Patent 6,206,920
    • Eliaz, R.E. U.S. Patent 6,206,920, 2001.
    • (2001)
    • Eliaz, R.E.1
  • 317
    • 65749090090 scopus 로고    scopus 로고
    • U.S. Patent 5,702,716
    • Dunn, R.L.; Tripton, A.P. U.S. Patent 5,702,716, 1997.
    • (1997)
    • Dunn, R.L.1    Tripton, A.P.2
  • 319
    • 0032866354 scopus 로고    scopus 로고
    • Phase inversion dynamics of PLGA solutions related to drug delivery. Part II. The role of solution thermodynamics and bath-side mass transfer
    • Brodbeck, K.J.; DesNoyer, J.R.; McHugh, A.J. Phase inversion dynamics of PLGA solutions related to drug delivery. Part II. The role of solution thermodynamics and bath-side mass transfer. J. Control. Release, 1999, 62 (3), 333.
    • (1999) J. Control. Release , vol.62 , Issue.3 , pp. 333
    • Brodbeck, K.J.1    DesNoyer, J.R.2    McHugh, A.J.3
  • 320
    • 0033032661 scopus 로고    scopus 로고
    • Phase inversion dynamics of PLGA solutions related to drug delivery
    • Graham, P.D.; Brodbeck, K.J.; McHugh, A.J. Phase inversion dynamics of PLGA solutions related to drug delivery. J. Control. Release, 1999, 58 (2), 233.
    • (1999) J. Control. Release , vol.58 , Issue.2 , pp. 233
    • Graham, P.D.1    Brodbeck, K.J.2    McHugh, A.J.3
  • 321
    • 0028858961 scopus 로고
    • Development of an in situ forming biodegradable poly-lactide-co-glycolide system for the controlled release of proteins
    • Lambert, W.J.; Peck, K.D. Development of an in situ forming biodegradable poly-lactide-co-glycolide system for the controlled release of proteins. J. Control. Release, 1995, 33 (1), 189.
    • (1995) J. Control. Release , vol.33 , Issue.1 , pp. 189
    • Lambert, W.J.1    Peck, K.D.2
  • 322
    • 65749106072 scopus 로고    scopus 로고
    • Ph.D.thesis, University of Basel: Basel
    • Matschke, C. Ph.D.thesis, University of Basel: Basel, 2002.
    • (2002)
    • Matschke, C.1
  • 324
    • 0031713190 scopus 로고    scopus 로고
    • In vivo properties of an in situ forming gel for parenteral delivery of macromolecular drugs
    • Joshi, R.; Arora, V.; Desjardins, J.P.; Robinson, D.; Himmelstein, K.J.; Iversen, P.L. In vivo properties of an in situ forming gel for parenteral delivery of macromolecular drugs. Pharm. Res., 1998, 15 (8), 1189.
    • (1998) Pharm. Res , vol.15 , Issue.8 , pp. 1189
    • Joshi, R.1    Arora, V.2    Desjardins, J.P.3    Robinson, D.4    Himmelstein, K.J.5    Iversen, P.L.6
  • 325
  • 326
    • 0033866658 scopus 로고    scopus 로고
    • In situ gel formulations for gene delivery: Release and myotoxicity studies
    • Ismail, F.A.; Napaporn, J.; Hughes, J.A.; Brazeau, G.A. In situ gel formulations for gene delivery: release and myotoxicity studies. Pharm. Dev. Technol., 2000, 5 (3), 391.
    • (2000) Pharm. Dev. Technol , vol.5 , Issue.3 , pp. 391
    • Ismail, F.A.1    Napaporn, J.2    Hughes, J.A.3    Brazeau, G.A.4
  • 327
    • 0034601880 scopus 로고    scopus 로고
    • Gene expression control by temperature with thermo-responsive polymeric gene carriers
    • Kurisawa, M.; Yokoyama, M.; Okano, T. Gene expression control by temperature with thermo-responsive polymeric gene carriers. J. Control. Release, 2000, 69 (1), 127.
    • (2000) J. Control. Release , vol.69 , Issue.1 , pp. 127
    • Kurisawa, M.1    Yokoyama, M.2    Okano, T.3
  • 330
    • 1642441833 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of recombinant silk-elastinlike hydrogels for cancer gene therapy
    • Megeed, Z.; Haider, M.; Li, D.; O'Malley, B.W., Jr.; Cappello, J.; Ghandehari, H. In vitro and in vivo evaluation of recombinant silk-elastinlike hydrogels for cancer gene therapy. J. Control. Release, 2004, 94 (2-3), 433.
    • (2004) J. Control. Release , vol.94 , Issue.2-3 , pp. 433
    • Megeed, Z.1    Haider, M.2    Li, D.3    O'Malley Jr., B.W.4    Cappello, J.5    Ghandehari, H.6
  • 331
    • 0034602597 scopus 로고    scopus 로고
    • Carbopol/pluronic phase change solutions for ophthalmic drug delivery
    • Lin, H.R.; Sung, K.C. Carbopol/pluronic phase change solutions for ophthalmic drug delivery. J. Control. Release, 2000, 69 (3), 379.
    • (2000) J. Control. Release , vol.69 , Issue.3 , pp. 379
    • Lin, H.R.1    Sung, K.C.2
  • 332
    • 0028960346 scopus 로고
    • Modification of in situ gelling behavior of carbopol solutions by hydroxypropyl methylcellulose
    • Kumar, S.; Himmelstein, K.J. Modification of in situ gelling behavior of carbopol solutions by hydroxypropyl methylcellulose. J. Pharm. Sci., 1995, 84 (3), 344.
    • (1995) J. Pharm. Sci , vol.84 , Issue.3 , pp. 344
    • Kumar, S.1    Himmelstein, K.J.2
  • 333
    • 0024988334 scopus 로고
    • Gene transfer into humans - immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction
    • Rosenberg, S.A.; Aebersold, P.; Cornetta, K.; Kasid, A.; Morgan, R.A.; Moen, R.; Karson, E.M.; Lotze, M.T.; Yang, J.C.; Topalian, S.L.; et al. Gene transfer into humans - immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N. Engl. J. Med., 1990, 323 (9), 570.
    • (1990) N. Engl. J. Med , vol.323 , Issue.9 , pp. 570
    • Rosenberg, S.A.1    Aebersold, P.2    Cornetta, K.3    Kasid, A.4    Morgan, R.A.5    Moen, R.6    Karson, E.M.7    Lotze, M.T.8    Yang, J.C.9    Topalian, S.L.10
  • 334
    • 0031710033 scopus 로고    scopus 로고
    • A third-generation lentivirus vector with a conditional packaging system
    • Dull, T.; Zufferey, R.; Kelly, M.; Mandel, R.J.; Nguyen, M.; Trono, D.; Naldini, L. A third-generation lentivirus vector with a conditional packaging system. J. Virol., 1998, 72 (11), 8463.
    • (1998) J. Virol , vol.72 , Issue.11 , pp. 8463
    • Dull, T.1    Zufferey, R.2    Kelly, M.3    Mandel, R.J.4    Nguyen, M.5    Trono, D.6    Naldini, L.7
  • 335
    • 0036819756 scopus 로고    scopus 로고
    • Advances towards targetable adenovirus vectors for gene therapy
    • Einfeld, D.A.; Roelvink, P.W. Advances towards targetable adenovirus vectors for gene therapy. Curr. Opin. Mol. Ther., 2002, 4 (5), 444.
    • (2002) Curr. Opin. Mol. Ther , vol.4 , Issue.5 , pp. 444
    • Einfeld, D.A.1    Roelvink, P.W.2
  • 336
    • 14744286188 scopus 로고
    • Particle bombardment-mediated gene transfer and expression in rat brain tissues
    • Jiao, S.; Cheng, L.; Wolff, J.A.; Yang, N.S. Particle bombardment-mediated gene transfer and expression in rat brain tissues. Biotechnology (N Y), 1993, 11 (4), 497.
    • (1993) Biotechnology (N Y) , vol.11 , Issue.4 , pp. 497
    • Jiao, S.1    Cheng, L.2    Wolff, J.A.3    Yang, N.S.4
  • 337
    • 2142751261 scopus 로고    scopus 로고
    • Evaluation of risks related to the use of adeno-associated virus-based vectors
    • Tenenbaum, L.; Lehtonen, E.; Monahan, P.E. Evaluation of risks related to the use of adeno-associated virus-based vectors. Curr. Gene Ther., 2003, 3 (6), 545.
    • (2003) Curr. Gene Ther , vol.3 , Issue.6 , pp. 545
    • Tenenbaum, L.1    Lehtonen, E.2    Monahan, P.E.3
  • 338
    • 0035819551 scopus 로고    scopus 로고
    • Gene delivery and gene therapy with herpes simplex virus-based vectors
    • Latchman, D.S. Gene delivery and gene therapy with herpes simplex virus-based vectors. Gene, 2001, 264 (1), 1.
    • (2001) Gene , vol.264 , Issue.1 , pp. 1
    • Latchman, D.S.1
  • 339
    • 0344707080 scopus 로고    scopus 로고
    • The role of helper lipids in cationic liposome-mediated gene transfer
    • Hui, S.W.; Langner, M.; Zhao, Y.L.; Ross, P.; Hurley, E.; Chan, K. The role of helper lipids in cationic liposome-mediated gene transfer. Biophys. J., 1996, 71 (2), 590.
    • (1996) Biophys. J , vol.71 , Issue.2 , pp. 590
    • Hui, S.W.1    Langner, M.2    Zhao, Y.L.3    Ross, P.4    Hurley, E.5    Chan, K.6
  • 342
    • 4644371368 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Electroporation and other physical methods
    • Wells, D.J. Gene therapy progress and prospects: electroporation and other physical methods. Gene Ther., 2004, 11 (18), 1363.
    • (2004) Gene Ther , vol.11 , Issue.18 , pp. 1363
    • Wells, D.J.1
  • 343
    • 12244263558 scopus 로고    scopus 로고
    • Gene transfer to subdermal tissues via a new gene gun design
    • Dileo, J.; Miller, T.E., Jr.; Chesnoy, S.; Huang, L. Gene transfer to subdermal tissues via a new gene gun design. Hum. Gene Ther., 2003, 14 (1), 79.
    • (2003) Hum. Gene Ther , vol.14 , Issue.1 , pp. 79
    • Dileo, J.1    Miller Jr., T.E.2    Chesnoy, S.3    Huang, L.4
  • 344
    • 0035989006 scopus 로고    scopus 로고
    • CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo
    • Yew, N.S.; Zhao, H.; Przybylska, M.; Wu, I.H.; Tousignant, J.D.; Scheule, R.K.; Cheng, S.H. CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo. Mol. Ther., 2002, 5 (6), 731.
    • (2002) Mol. Ther , vol.5 , Issue.6 , pp. 731
    • Yew, N.S.1    Zhao, H.2    Przybylska, M.3    Wu, I.H.4    Tousignant, J.D.5    Scheule, R.K.6    Cheng, S.H.7
  • 346
    • 28744445460 scopus 로고    scopus 로고
    • Dendrimer biocompatibility and toxicity
    • Duncan, R.; Izzo, L. Dendrimer biocompatibility and toxicity. Adv. Drug Deliv. Rev., 2005, 57 (15), 2215.
    • (2005) Adv. Drug Deliv. Rev , vol.57 , Issue.15 , pp. 2215
    • Duncan, R.1    Izzo, L.2
  • 347
    • 0035850212 scopus 로고    scopus 로고
    • Evaluation of polyplexes as gene transfer agents
    • Gebhart, C.L.; Kabanov, A.V. Evaluation of polyplexes as gene transfer agents. J. Control. Release, 2001, 73 (2-3), 401.
    • (2001) J. Control. Release , vol.73 , Issue.2-3 , pp. 401
    • Gebhart, C.L.1    Kabanov, A.V.2
  • 349
    • 0024144884 scopus 로고
    • Bio-compatibility of chitosan by oral and intravenous administrations
    • Hirano, S.; Seino, H.; Akiyama, Y.; Nonaka, I. Bio-compatibility of chitosan by oral and intravenous administrations. Polym. Mater. Sci. Eng., 1988, 59, 897.
    • (1988) Polym. Mater. Sci. Eng , vol.59 , pp. 897
    • Hirano, S.1    Seino, H.2    Akiyama, Y.3    Nonaka, I.4
  • 350
    • 0344440901 scopus 로고    scopus 로고
    • Efficient gene delivery by urocanic acid-modified chitosan
    • Kim, T.H.; Ihm, J.E.; Choi, Y.J.; Nah, J.W.; Cho, C.S. Efficient gene delivery by urocanic acid-modified chitosan. J. Control. Release, 2003, 93 (3), 389.
    • (2003) J. Control. Release , vol.93 , Issue.3 , pp. 389
    • Kim, T.H.1    Ihm, J.E.2    Choi, Y.J.3    Nah, J.W.4    Cho, C.S.5
  • 351
    • 0028430957 scopus 로고
    • Folate receptor mediated DNA delivery into tumor cells: Potosomal disruption results in enhanced gene expression
    • Gottschalk, S.; Cristiano, R.J.; Smith, L.C.; Woo, S.L. Folate receptor mediated DNA delivery into tumor cells: potosomal disruption results in enhanced gene expression. Gene Ther., 1994, 1 (3), 185.
    • (1994) Gene Ther , vol.1 , Issue.3 , pp. 185
    • Gottschalk, S.1    Cristiano, R.J.2    Smith, L.C.3    Woo, S.L.4
  • 352
    • 53149131335 scopus 로고    scopus 로고
    • Receptor-targeted gene delivery via folate-conjugated polyethylenimine
    • Guo, W.; Lee, R.L. Receptor-targeted gene delivery via folate-conjugated polyethylenimine. AAPS Pharm Sci., 1999, 1 (4), E19.
    • (1999) AAPS Pharm Sci , vol.1 , Issue.4
    • Guo, W.1    Lee, R.L.2
  • 353
    • 0025313130 scopus 로고
    • Transferrin-polycation-mediated introduction of DNA into human leukemic cells: Stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels
    • Cotten, M.; Langle-Rouault, F.; Kirlappos, H.; Wagner, E.; Mechtler, K.; Zenke, M.; Beug, H.; Birnstiel, M.L. Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. Proc. Natl. Acad. Sci. USA, 1990, 87 (11), 4033.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , Issue.11 , pp. 4033
    • Cotten, M.1    Langle-Rouault, F.2    Kirlappos, H.3    Wagner, E.4    Mechtler, K.5    Zenke, M.6    Beug, H.7    Birnstiel, M.L.8
  • 355
  • 356
    • 0141715047 scopus 로고    scopus 로고
    • Integrin targeting using RGD-PEI conjugates for in vitro gene transfer
    • Kunath, K.; Merdan, T.; Hegener, O.; Haberlein, H.; Kissel, T. Integrin targeting using RGD-PEI conjugates for in vitro gene transfer. J. Gene Med., 2003, 5 (7), 588.
    • (2003) J. Gene Med , vol.5 , Issue.7 , pp. 588
    • Kunath, K.1    Merdan, T.2    Hegener, O.3    Haberlein, H.4    Kissel, T.5
  • 357
    • 0032956746 scopus 로고    scopus 로고
    • Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway
    • Erbacher, P.; Remy, J.S.; Behr, J.P. Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway. Gene Ther., 1999, 6 (1), 138.
    • (1999) Gene Ther , vol.6 , Issue.1 , pp. 138
    • Erbacher, P.1    Remy, J.S.2    Behr, J.P.3
  • 358
    • 0034924636 scopus 로고    scopus 로고
    • Different strategies for formation of pegylated EGF-conjugated PEI/DNA complexes for targeted gene delivery
    • Blessing, T.; Kursa, M.; Holzhauser, R.; Kircheis, R.; Wagner, E. Different strategies for formation of pegylated EGF-conjugated PEI/DNA complexes for targeted gene delivery. Bioconjug. Chem., 2001, 12 (4), 529.
    • (2001) Bioconjug. Chem , vol.12 , Issue.4 , pp. 529
    • Blessing, T.1    Kursa, M.2    Holzhauser, R.3    Kircheis, R.4    Wagner, E.5
  • 359
    • 0031671232 scopus 로고    scopus 로고
    • The contribution of poly-L-lysine, epidermal growth factor and streptavidin to EGF/PLL/DNA polyplex formation
    • Xu, B.; Wiehle, S.; Roth, J.A.; Cristiano, R.J. The contribution of poly-L-lysine, epidermal growth factor and streptavidin to EGF/PLL/DNA polyplex formation. Gene Ther., 1998, 5 (9), 1235.
    • (1998) Gene Ther , vol.5 , Issue.9 , pp. 1235
    • Xu, B.1    Wiehle, S.2    Roth, J.A.3    Cristiano, R.J.4
  • 360
    • 0031281282 scopus 로고    scopus 로고
    • In vitro gene delivery to hepatocytes with galactosylated polyethylenimine
    • Zanta, M.A.; Boussif, O.; Adib, A.; Behr, J.P. In vitro gene delivery to hepatocytes with galactosylated polyethylenimine. Bioconjug. Chem., 1997, 8 (6), 839.
    • (1997) Bioconjug. Chem , vol.8 , Issue.6 , pp. 839
    • Zanta, M.A.1    Boussif, O.2    Adib, A.3    Behr, J.P.4
  • 361
    • 0033167367 scopus 로고    scopus 로고
    • Size reduction of galactosylated PEI/DNA complexes improves lectin-mediated gene transfer into hepatocytes
    • Bettinger, T.; Remy, J.S.; Erbacher, P. Size reduction of galactosylated PEI/DNA complexes improves lectin-mediated gene transfer into hepatocytes. Bioconjug. Chem., 1999, 10 (4), 558.
    • (1999) Bioconjug. Chem , vol.10 , Issue.4 , pp. 558
    • Bettinger, T.1    Remy, J.S.2    Erbacher, P.3
  • 362
    • 0033586301 scopus 로고    scopus 로고
    • Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection
    • Diebold, S.S.; Lehrmann, H.; Kursa, M.; Wagner, E.; Cotten, M.; Zenke, M. Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection. Hum. Gene Ther., 1999, 10 (5), 775.
    • (1999) Hum. Gene Ther , vol.10 , Issue.5 , pp. 775
    • Diebold, S.S.1    Lehrmann, H.2    Kursa, M.3    Wagner, E.4    Cotten, M.5    Zenke, M.6
  • 365
    • 0001121655 scopus 로고    scopus 로고
    • Lactose-poly(ethylene glycol)-grafted poly-L-lysine as hepatoma cell-tapgeted gene carrier
    • Choi, Y.H.; Liu, F.; Park, J.S.; Kim, S.W. Lactose-poly(ethylene glycol)-grafted poly-L-lysine as hepatoma cell-tapgeted gene carrier. Bioconjug. Chem., 1998, 9 (6), 708.
    • (1998) Bioconjug. Chem , vol.9 , Issue.6 , pp. 708
    • Choi, Y.H.1    Liu, F.2    Park, J.S.3    Kim, S.W.4
  • 366
    • 0029328597 scopus 로고
    • Glycosylated polylysine/DNA complexes: Gene transfer efficiency in relation with the size and the sugar substitution level of glycosylated polylysines and with the plasmid size
    • Erbacher, P.; Roche, A.C.; Monsigny, M.; Midoux, P. Glycosylated polylysine/DNA complexes: gene transfer efficiency in relation with the size and the sugar substitution level of glycosylated polylysines and with the plasmid size. Bioconjug. Chem., 1995, 6 (4), 401.
    • (1995) Bioconjug. Chem , vol.6 , Issue.4 , pp. 401
    • Erbacher, P.1    Roche, A.C.2    Monsigny, M.3    Midoux, P.4
  • 369
    • 34248189593 scopus 로고    scopus 로고
    • Characterization of lactoferrin as a targeting ligand for nonviral gene delivery to airway epithelial cells
    • Elfinger, M.; Maucksch, C.; Rudolph, C. Characterization of lactoferrin as a targeting ligand for nonviral gene delivery to airway epithelial cells. Biomaterials, 2007, 28 (23), 3448.
    • (2007) Biomaterials , vol.28 , Issue.23 , pp. 3448
    • Elfinger, M.1    Maucksch, C.2    Rudolph, C.3
  • 370
    • 21244448447 scopus 로고    scopus 로고
    • Tumor-targeted gene delivery using poly(ethylene glycol)-modified gelatin nanoparticles: In vitro and in vivo studies
    • Kaul, G.; Amiji, M. Tumor-targeted gene delivery using poly(ethylene glycol)-modified gelatin nanoparticles: in vitro and in vivo studies. Pharm. Res., 2005, 22 (6), 951.
    • (2005) Pharm. Res , vol.22 , Issue.6 , pp. 951
    • Kaul, G.1    Amiji, M.2
  • 372
    • 1342269151 scopus 로고    scopus 로고
    • Matrix-immobilized growth factor gene therapy enhances tissue repair
    • Gu, D.N., T.; Phillips, M.L., Chandler, L.A., and Sosnowiski, B.A. Matrix-immobilized growth factor gene therapy enhances tissue repair. Wounds, 2004, 16 (1), 34.
    • (2004) Wounds , vol.16 , Issue.1 , pp. 34
    • Gu, D.N.T.1    Phillips, M.L.2    Chandler, L.A.3    Sosnowiski, B.A.4
  • 373
    • 4243070878 scopus 로고    scopus 로고
    • Suppression of tumor metastasis by NK4 plasmid DNA released from cationized gelatin
    • Kushibiki, T.; Matsumoto, K.; Nakamura, T.; Tabata, Y. Suppression of tumor metastasis by NK4 plasmid DNA released from cationized gelatin. Gene Ther., 2004, 11 (15), 1205.
    • (2004) Gene Ther , vol.11 , Issue.15 , pp. 1205
    • Kushibiki, T.1    Matsumoto, K.2    Nakamura, T.3    Tabata, Y.4
  • 374
    • 3242715129 scopus 로고    scopus 로고
    • Suppression of the progress of disseminated pancreatic cancer cells by NK4 plasmid DNA released from cationized gelatin microspheres
    • Kushibiki, T.; Matsumoto, K.; Nakamura, T.; Tabata, Y. Suppression of the progress of disseminated pancreatic cancer cells by NK4 plasmid DNA released from cationized gelatin microspheres. Pharm. Res., 2004, 21(7), 1109.
    • (2004) Pharm. Res , vol.21 , Issue.7 , pp. 1109
    • Kushibiki, T.1    Matsumoto, K.2    Nakamura, T.3    Tabata, Y.4
  • 377
    • 0034964447 scopus 로고    scopus 로고
    • The structure and biological features of fibrinogen and fibrin
    • Mosesson, M.W.; Siebenlist, K.R.; Meh, D.A. The structure and biological features of fibrinogen and fibrin. Ann. N. Y. Acad. Sci., 2001, 936, 11.
    • (2001) Ann. N. Y. Acad. Sci , vol.936 , pp. 11
    • Mosesson, M.W.1    Siebenlist, K.R.2    Meh, D.A.3
  • 378
    • 4644308743 scopus 로고    scopus 로고
    • Enhanced neovasculature formation in ischemic myocardium following delivery of pleiotrophin plasmid in a biopolymer
    • Christman, K.L.; Fang, Q.; Yee, M.S.; Johnson, K.R.; Sievers, R.E.; Lee, R.J. Enhanced neovasculature formation in ischemic myocardium following delivery of pleiotrophin plasmid in a biopolymer. Biomaterials, 2005, 26 (10), 1139.
    • (2005) Biomaterials , vol.26 , Issue.10 , pp. 1139
    • Christman, K.L.1    Fang, Q.2    Yee, M.S.3    Johnson, K.R.4    Sievers, R.E.5    Lee, R.J.6
  • 380
    • 0034666728 scopus 로고    scopus 로고
    • Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: Effect of route of inoculation on immune response
    • Mittal, S.K.; Aggarwal, N.; Sailaja, G.; van Olphen, A.; HogenEsch, H.; North, A.; Hays, J.; Moffatt, S. Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: effect of route of inoculation on immune response. Vaccine, 2000, 19 (2-3), 253.
    • (2000) Vaccine , vol.19 , Issue.2-3 , pp. 253
    • Mittal, S.K.1    Aggarwal, N.2    Sailaja, G.3    van Olphen, A.4    HogenEsch, H.5    North, A.6    Hays, J.7    Moffatt, S.8


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