Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium

Molecular Therapy

Volumn 12, Issue 3, 2005, Pages 493-501

  Rudolph, Carsten ^a   Schillinger, Ulrike ^b   Ortiz, Aurora ^a   Plank, Christian ^b   Golas, Monika M ^c   Sander, Bjoern ^c   Stark, Holger ^c   Rosenecker, Joseph ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

Aerosol; Distilled water; Gene therapy; Gene transfer; Nonviral; PEI

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; BUFFER; EGTAZIC ACID; INDOMETACIN; ISOTONIC SOLUTION; NANOPARTICLE; PLASMID DNA; PLASMID VECTOR; POLIDOCANOL; POLYETHYLENEIMINE; SODIUM CHLORIDE;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DISTILLATION; DNA VECTOR; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG MEGADOSE; FEMALE; GENE EXPRESSION; GENE TARGETING; GENE VECTOR; GENETIC TRANSFECTION; IN VIVO STUDY; LUNG ALVEOLUS EPITHELIUM; MOUSE; MOUSE STRAIN; NEBULIZATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; OSMOLARITY; PARTICLE SIZE; TIGHT JUNCTION;

AEROSOLS; ANIMALS; BIOPHYSICS; CRYOPRESERVATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; EPITHELIUM; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; INDOMETHACIN; LUNG; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON; PARTICLE SIZE; PLASMIDS; POLYETHYLENE GLYCOLS; TRANSFECTION; TRANSGENES; WATER;

EID: 23844528337     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.03.002     Document Type: Article

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