Influence of formulation parameters on the characteristics of poly(D,L-lactide-co-glycolide) microspheres containing poly(L-lysine) complexed plasmid DNA

Journal of Controlled Release

Volumn 60, Issue 2-3, 1999, Pages 279-286

  Capan, Yilmaz ^a   Woo, Byung H ^b   Gebrekidan, Sisay ^b   Ahmed, Shamim ^b   DeLuca, Patrick P ^b  

^a HACETTEPE UNIVERSITY   (Turkey)

^b University of Kentucky   (United States)

Author keywords

DNase; Microsphere; Plasmid DNA; Poly(D,L lactide co glycolide); Poly(L lysine)

Indexed keywords

MICROSPHERE; PLASMID DNA; POLYGLACTIN; POLYLYSINE; RESOMER; UNCLASSIFIED DRUG;

ARTICLE; DNA BINDING; DRUG RELEASE; DRUG STABILITY; IN VITRO STUDY; MOLECULAR WEIGHT; PARTICLE SIZE; PRIORITY JOURNAL; VISCOSITY;

DELAYED-ACTION PREPARATIONS; DEOXYRIBONUCLEASE I; DNA ADDUCTS; ELECTROPHORESIS, AGAR GEL; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; PLASMIDS; POLYGLYCOLIC ACID; POLYLYSINE; POLYMERS; POLYVINYL ALCOHOL; POVIDONE; SURFACE-ACTIVE AGENTS;

EID: 0032765726     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00076-0     Document Type: Article

References (22)

1. Middaugh C.R., Evans R.K., Montgomery D.L., Casimiro D.R. Analysis of plasmid DNA from a pharmaceutical perspective. J. Pharm. Sci. 87:1998;130-146.
2. Hedley M.L., Curley J., Urban T. Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell response. Nature Med. 4:1998;365-368.
3. Jones D.H., Corris S., McDonald S., Clegg J.C.S., Farrar G.H. Poly(D,L-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encodes protein after oral administration. Vaccine. 15:1997;414-817.
4. Kawabata K., Takkura Y., Hashida M. The fate of plasmid DNA after intravenous injection in mice: Involvement of scavenger receptors in its hepatic uptake. Pharm. Res. 12:1995;825-830.
5. Yoshida M., Mahato R.I., Kawabata K., Takakura Y., Hashida M. Disposition characteristics of plasmid DNA in the single-pass rate liver perfusion system. Pharm. Res. 13:1996;599-603.
6. Lee R.J., Huang L. Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J. Biol. Chem. 271:1996;8481-8487.
7. McDonal R.J., Liggit H.D., Roche L., Nguyen H.T., Pearlman R., Raabe O.G., Bussey L.B., Gorman C.M. Aerosol delivery of lipid-DNA complexes to lungs of Rhesus monkeys. Pharm. Res. 15:1998;671-678.
8. Osaka G., Carey K., Cuthberson A., Godowski P., Patapoff T., Ryan A., Gadek T., Mordenti G. Pharmacokinetics, tissue distribution, and expression of plasmid (33P) DNA following intravenous administration of DNA/cationic lipid complexes in mice: use of a novel radionuclide approach. J. Pharm. Sci. 85:1996;612-618.
9. Adami R.C., Collard W.T., Gupta S.A., Kwok K.Y., Bonadio J., Rice K.G. Stability of peptide-condensed plasmid DNA formulations. J. Pharm. Sci. 87:1998;678-683.
10. Pouton C.W., Lucas P., Thomas B.J., Uduehi A.N., Milray D.A., Moss S.H. Polycation-DNA complex for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids. J. Control. Rel. 53:1998;289-299.
11. Mehta R.C., Jeyanthi R., Calis S., Thanoo B.C., Burton K.W., DeLuca P.P. Biodegradable microspheres as depot system for parenteral delivery of peptide drugs. J. Control. Rel. 29:1994;375-384.
12. D.H. Lewis, Controlled release of bioactive agents from lactide/glycolide polymers, M. Chasin, R. Langer (Eds.). Biodegradable polymers as drug delivery systems. Marcel Dekker, New York, 1990, pp. 1-41.
13. Tabata Y., Ikada Y. Phagocytosis of polymer microspheres by macrophages. Adv. Polymer Sci. 94:1990;107-141.
14. Blanco-Prieto M.J., Fattal E., Gulik A., Dedieu J.C., Roques B.P., Couvreur P. Characterization and morphological analysis of a cholecystokinin derivative peptide-loaded poly(lactide-co-glycolide) microspheres prepared by water-in-oil emulsion solvent evaporation method. J. Control. Rel. 43:1997;81-87.
15. Hermann J., Bodmeier R. Somatostatin containing biodegradable microspheres prepared by a modified solvent evaporation method based on w/o/w-multiple emulsions. Int. J. Pharm. 126:1995;129-138.
16. Rafati H., Coombes A.G.A., Adler J., Holland H., Davis S.S. Protein-loaded poly(D,L-lactide-co glycolide) microparticles for oral administration: formulation, structural and release characteristics. J. Control. Rel. 43:1997;89-102.
17. Cleland J.L., Duenas E., Daugherty A., Marian M., Yang J., Wilson M., Celniker A.C., Shahzamani A., Quarmby V., Chu H., Mukku V., Mac A., Roussakis M., Gillette N., Boyd B., Yeung D., Brooks D., Maa Y.F., Hsu C., Jones A.J.S. Recombinant Human growth hormone poly (lactic-co-glycolic acid) PLGA microspheres provide a long lasting effect. J. Control. Rel. 49:1997;193-205.
18. Ghaderi R., Sturesson C., Carlfors J. Effect of preparative parameters on the characteristics of poly(D,L-lactide-co-glycolide) microspheres made by the double emulsion method. Int. J. Pharm. 141:1996;205-216.
19. Aftabroushad S., Doelker E. Factors influencing the entrapment of a water soluble model drug into injectable microparticles prepared using solvent evaporation and phase separation techniques. Eur. J. Pharm. Biopharm. 40:1994;237-242.
20. Capan Y., Woo B.H., Gebrekidan S., Ahmed S., DeLuca P.P. Preparation and characterization of poly(D,L-lactide-co-glycolide) microspheres for controlled release of poly(L-lysine) complexed plasmid DNA. Pharm. Res. 16:1999;509-513.
21. Y. Capan, B. H. Woo, S. Gebrekidan, S. Ahmed, P. P. DeLuca, Stability of poly(L-lysine) complexed plasmid DNA during mechanical stress and DNase I treatment. Pharm. Dev. Tech., in press.
22. Mehta R.C., Thanoo B.C., DeLuca P.P. Peptide containing microspheres from low molecular weight and hydrophilic poly(D,L-lactide-co-glycolide). J. Control. Rel. 41:1996;249-257.