Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle

Pharmaceutical Research

Volumn 13, Issue 5, 1996, Pages 701-709

  Mumper, Russell J ^a   Duguid, John G ^a   Anwer, Khursheed ^a   Barron, Melisa K ^a   Nitta, Hiroaki ^a   Rolland, Alain P ^a  

^a GeneMedicine Inc   (United States)

Author keywords

DNA plasmid; Gene delivery system; Gene expression system; Muscle; Non viral gene therapy; Polyvinyl alcohol; Polyvinyl pyrrolidone

Indexed keywords

KOLLIDON K17PF; NUCLEASE; POLYMER; POLYVINYL ALCOHOL; POLYVINYL DERIVATIVE; POVIDONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; DISPERSION; DRUG DELIVERY SYSTEM; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; IMMUNOHISTOCHEMISTRY; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PLASMID; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

ANIMALS; BETA-GALACTOSIDASE; DNA, RECOMBINANT; DRUG CARRIERS; GENE TARGETING; HYDROGEN BONDING; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE, SKELETAL; PLASMIDS; POLYVINYL ALCOHOL; POVIDONE; RATS; RATS, INBRED F344; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 0029891916     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016039330870     Document Type: Article

References (16)

1. J. A. Wolff, R. W. Malone, P. Williams, C. Wang, G. Acsadi, A. Jani, and P. L. Feigner. Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468 (1990).
2. S. Jiao, P. Williams, R. K. Berg, B. A. Hodgeman, L. Liu, G. Repetto, and J. A. Wolff. Direct gene transfer into nonhuman primate myofibers in vivo. Hum. Gene Ther. 3:21-33 (1992).
3. M. Manthorpe, F. Cornefert-Jensen, J. Hartikka, J. Feigner, A. Rundell, M, Margalith, and V. Dwarki. Gene therapy by intramuscular injection of plasmid DNA: studies on Firely Luciferase gene expression in mice. Hum. Gene Ther. 4:419-431 (1993).
4. M. Y. Levy, K. B. Meyer, L. Barren, and F. C. Szoka. Mechanism of gene uptake and expression in adult mouse skeletal muscle. Pharm. Res. 11:317 (1994).
5. C. M. Gorman, L. F. Moffat, and B. H. Howard. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051 (1982).
6. V. Buhler. Kollidon: Polyvinylpyrrolidone for the pharmaceutical industry. BASF Aktiengesellschaft Feinchemie, Ludwigshafen, 1993.
7. W. R. Gombotz, S. C. Pankey, D. Phan, R. Drager, K. Donaldson, K. P. Antonsen, A. S. Hoffman, and H. V. Raff. The stabilization of human IgM monoclonal antibody with poly(vinylpyrrolidone). Pharm. Res. 11:624-632 (1994).
8. L. D. Murphy and S. B. Zimmerman. Macromolecular crowding effects on the interaction of DNA with Escherichia coli DNA-binding proteins: a model for bacterial nucleoid stabilization. Biochim. Biophys. Acta. 1219:277-84 (1994).
9. Y. Galaev, N. Garg, and B. Mattiasson. Interaction of Cibacron blue with polymers: implications for polymer-shielded dye-affinity chromatography of phosphofructokinase from baker's yeast. J. Chromatogr. A. 684:45-54 (1994).
10. I. Matsubara, Y. E. Goldman, and R. M. Simmons. Changes in the lateral filament spacing of skinned muscle fibres when cross-bridges attach. J. Mol. iolM. 173:15-33 (1984).
11. G. D. Rieser, R. A. Sabbadini, and P. J. Paolini. The effects of chemical cross-linking agents on calcium-induced structural changes in skinned muscle fibers. Origin within thick filaments detected by optical diffraction methods. Biochim. et Biophy. Acta. 707:178-189 (1982).
12. 2+ release in skinned muscle fibres of the toad. J. Physiol. Lond. 464:629-48 (1993).
13. K. Tyml. Heterogeneity of microvascular flow in rat skeletal muscle is reduced by contraction and by hemodilution. Int. J. Micmcirc. Clin. Exp. 10:75-86 (1991).
14. M. Otagiri, T. Imai, H. Koinuma, and U. Matsumoto. Spectroscopic study of the interaction of coumarin anticoagulant drugs with polyvinylpyrrolidone. J. Pharm. Biomed. Anal. 7:929-35 (1989).
15. A. V. Kabanov and V. A. Kabanov. DNA complexes with polycations for the delivery of genetic material into cells. Bioconj. Chem. 6:7-20 (1995).
16. S. Keipert and R. Voigt. Interaction between macromolecular adjuvants and drugs. Improvement of the solubility characteristics of benzodiazepine derivatives with polyvinylpyrrolidone. Pharmazie 41:400-404 (1986).