Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes

Science

Volumn 275, Issue 5301, 1997, Pages 810-814

  Rädler, Joachim O ^a,b   Koltover, Ilya ^b   Salditt, Tim ^b   Safinya, Cyrus R ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b University of California at Santa Barbara   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; LIPOSOME;

ARTICLE; DNA STRUCTURE; GENE THERAPY; INTERCALATION COMPLEX; MICROSCOPY; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

BACTERIOPHAGE LAMBDA; CATIONS; CHEMISTRY, PHYSICAL; DNA; DNA, VIRAL; FATTY ACIDS, MONOUNSATURATED; ISOELECTRIC POINT; LIGHT; LIPID BILAYERS; LIPOSOMES; MICROSCOPY, FLUORESCENCE; MICROSCOPY, INTERFERENCE; NUCLEIC ACID CONFORMATION; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PLASMIDS; QUATERNARY AMMONIUM COMPOUNDS; SCATTERING, RADIATION; X-RAY DIFFRACTION;

EID: 0031036238     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.275.5301.810     Document Type: Article

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50. We acknowledge useful discussions with R. Bruinsma, N. Dan, W. Gelbart, P. Pincus, J. Prost, T. Lubensky, and D. Lasic. Supported in part by NSF grant DMR-9624091, the Petroleum Research Fund (31352-AC7), and a Los Alamos CULAR grant STB/ UC:96-108. J.O.R. and T.S. acknowledge partial support by DFG (Ra 655/1-1) and DAAD scholarships, respectively. The Materials Research Laboratory at Santa Barbara is supported by the NSF under grant DMR-9632716. The synchrotron experiments were carried out at Stanford (SSRL) supported by the U.S. Department of Energy.