Chitosan-based vector/DNA complexes for gene delivery: Biophysical characteristics and transfection ability

Pharmaceutical Research

Volumn 15, Issue 9, 1998, Pages 1332-1339

  Erbacher, Patrick ^a   Zou, Shaomin ^a   Bettinger, Thierry ^a   Steffan, Anne Marie ^b   Remy, Jean Serge ^a  

^a CNRS   (France)

^b INSERM   (France)

Author keywords

Cationic polymer; Chitosan; Gene therapy; Gene transfer; Polyethylenimine

Indexed keywords

ARTICLE; BIOPHYSICS; DNA PROTEIN COMPLEX; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; HUMAN; HUMAN CELL; LIGHT SCATTERING; PARTICLE SIZE; PLASMID; POLYMERIZATION; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

BIOPOLYMERS; CHITIN; CHITOSAN; DNA; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HELA CELLS; HUMANS; LECTINS; POLYETHYLENEIMINE; TRANSFECTION;

EID: 0031722107     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011981000671     Document Type: Article

References (21)

1. F. D. Ledley. Pharmaceutical approach to somatic gene therapy. Pharm. Res. 13:1595-1614 (1996).
2. G. Y. Wu and C. H. Wu. Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. J. Biol. Chem. 262:4429-4432 (1987).
3. J. Haensler and F. C. Szoka Jr. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjugate Chem. 4:372-379 (1993).
4. O. Boussif, F. Lezoualc'h, M. A. Zanta, M. D. Mergny, D. Scherman, B. Demeneix, and J. P. Behr. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. USA 92:7297-7301 (1995).
5. M. X. Tang and F. C. Szoka. The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther. 4:823-832 (1997).
6. J. P. Behr, B. Demeneix, J. P. Loeffler, and J. Perez-Mutul. Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA. Proc. Natl. Acad. Sci. USA 89:6982-6986 (1989).
7. K. A. Mislick and J. D. Baldeschwieler. Evidence for the role of proteoglycans in cation-mediated gene transfer. Proc. Natl. Acad. Sci. USA 93:12349-12354 (1996).
8. F. Labat-Moleur, A. M. Steffan, C. Brisson, H. Perron, O. Feugeas, P. Furstenberger, F. Oberling, E. Brambilla, and J. P. Behr. An electron microscopy study into the mechanism of gene transfer with lipopolyamines. Gene Ther. 3:1010-1017 (1996).
9. K. Roy, H. Q. Mao, and K. W. Leong. DNA-chitosan nanospheres: transfection efficiency and cellular uptake. Proceed. Int'l. Symp. Control. Rel. Bioact. Mater. 24:673-674 (1997).
10. J. L. Murata, Y. Ohya, and T. Ouchi. Possibility of application of quaternary chitosan having pendant galactose residues as gene delivery tool. Carbohydrate Polymers 29:69-74 (1996).
11. M. Monsigny, C. Petit, and A. C. Roche. Colorimetric determination of neutral sugars by a recorcinol sulfuric acid micromethod. Anal. Biochem. 175:525-530 (1988).
12. M. A. Zanta, O. Boussif, A. Adib, and J. P. Behr. In vitro gene delivery to hepatocytes with galactosylated polyethylenimine. Bioconjugate Chem 8:839-844 (1997).
13. C. K. Goldman, L. Soroceanu, N. Smith, Y. Gillepsie, W. Shaw, S. Burgess, G. Bilbao, and D. T. Curiel. In vitro and in vivo gene delivery mediated by a synthetic polycationic amino polymer. Nature Biotech. 15:462-466 (1997).
14. M. Cotten, F. Längle-Rouault, H. Kirlapos, E. Wagner, K. Mechtler, M. Zenke, H. Beug, and M. L. Birnstiel. Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate tansferrin receptor levels. Proc. Natl. Acad. Sci. USA 87:4033-4037 (1990).
15. P. Midoux, C. Mendès, A. Legrand, J. Raimond, R. Mayer, M. Monsigny, and A. C. Roche. Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells. Nucleic Acids Res. 21:871-878 (1993).
16. A. S. Chuck, M. F. Clarke, and B. O. Palsson. Retroviral infection is limited by brownian motion. Human Gene Ther. 7: 1527-1534 (1996).
17. D. T. Curiel, S. Agarwal, E. Wagner, and M. Gotten. Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proc. Natl. Acad. Sci. USA 88:8850-8854 (1991).
18. C. Plank, K. Zatloukal, M. Cotten, K. Mechtler, and E. Wagner. Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetraantennary galactose ligand. Bioconjugate Chem. 3:533-539 (1992).
19. C. Planck, B. Oberhauser, K. Mechtler, C. Koch, and E. Wagner. The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer system. J. Biol. Chem. 269:12918-12924 (1994).
20. P. Erbacher, A. C. Roche, M. Monsigny, and P. Midoux. Putative role of chloroquine in gene transfer into a hepatoma cell line by DNA/lactosylated polylysine complexes. Exp. Cell Res. 225:186-194 (1996).
21. J. P. Behr. The proton sponge: a trick to enter cells the viruses did not think of. Chimia 51:27-30 (1997).