Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery

Gene Therapy

Volumn 6, Issue 4, 1999, Pages 643-650

  Dash, P R ^a   Read, M L ^a   Barrett, L B ^a   Wolfert, M A ^a   Seymour, L W ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

Albumin; Gene delivery; Intravenous; Polycation DNA complexes; Protein binding

Indexed keywords

ALBUMIN; ETHIDIUM BROMIDE; PHOSPHORUS 32; POLYELECTROLYTE; POLYLYSINE; SERUM ALBUMIN;

AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ARTICLE; BODY DISTRIBUTION; COMPLEMENT ACTIVATION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG PROTEIN BINDING; FLUORESCENCE ANALYSIS; GENE TARGETING; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; MOUSE; NONHUMAN; PLASMA CLEARANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TURBIDITY; ZETA POTENTIAL;

ALBUMINS; ANIMALS; DNA; ELECTROPHORESIS, AGAR GEL; FEMALE; GENE THERAPY; GENETIC VECTORS; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED BALB C; POLYLYSINE; PROTEIN BINDING; TRANSFECTION; TREATMENT FAILURE;

ANIMALIA;

EID: 0032959729     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300843     Document Type: Article

References (26)

1. Marshall E. Less hype, more biology needed for gene therapy. Science 1995; 270: 1751.
2. Friedmann T. Overcoming the obstacles to gene therapy. Scientific American 1997; June: 80-85.
3. Velu T. Gene transfer and therapy in Europe: research, development and clinical trials. Publication of the European Union: Brussels, 1996.
4. Seymour LW. Passive tumor targeting of soluble macromolecules and drug conjugates. Crit Rev Ther Drug Carrier Syst 1992; 9: 135-187.
5. Takakura Y, Hashida M. Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations and biodistribution. Pharm Res 1996; 13: 820-831.
6. Graham RW. Encapsulated transmembrane carrier systems for gene therapy. Proceedings of the Keystone Symposium on Synthetic Non-viral Gene Delivery Systems 1998; 135 (Abstr. 212).
7. Dash PR, Toncheva V, Schacht E, Seymour LW. Synthetic polymers for vectorial delivery of DNA: characterisation of polymer-DNA complexes by photon correlation spectroscopy, stability to nuclease degradation and disruption by polyanions in vitro. J Cont Release 1997; 48: 269-276.
8. Wolfert MA et al. Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers. Hum Gene Ther 1996; 7: 2123-2133.
9. Wolfert MA, Seymour LW. Chloroquine and amphipathic helices show synergistic transfection activity. Gene Therapy 1998; 5: 409-414.
10. Wolfert MA, Seymour LW. Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of polyelectrolyte complexes formed with DNA. Gene Therapy 1996; 3: 269-273.
11. Ward CM, Seymour LW. A novel assay for determination of polycation concentration using turbidometry. J Bioact Compat Polym 1998 (in press).
12. Li S, Huang L. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Therapy 1997; 4: 891-900.
13. Liu F, Qi H, Huang L, Liu, D. Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration. Gene Therapy 1997; 4: 517-523.
14. Plank C, Mchtler K, Szoka FC, Wagner E. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum Gene Ther 1996; 7: 1437-1446.
15. Chiou HC et al. Enhanced resistance to nuclease degradation of nucleic acids complexed to asialoglycoprotein-polylysine carriers. Nucleic Acids Res 1994; 22: 5439-5446.
16. Oja CD, Semple SC, Chonn A, Cullis P. Influence of dose on liposome clearance. Biochim Biophys Acta 1996; 1281: 31-37.
17. Semple SC, Chonn A, Cullis P. Influence of cholesterol on the association of plasma proteins with liposomes. Biochemistry 1996; 35: 2521-2525.
18. Boussif O et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo - polyethyleneimine. Proc Natl Acad Sci USA 1995; 92: 7297-7301.
19. Boussif O, Zanta MA, Behr JP. Optimised galenics improve in vitro gene transfer with cationic molecules up to a thousand fold. Gene Therapy 1996; 3: 1074-1080.
20. Semple SC, Chonn A, Cullis PR. Influence of cholesterol on the association of plasma proteins with liposomes. Biochemistry 1996; 35: 2521-2525.
21. Hu QR, Liu DX. Co-existence of serum-dependent mechanisms for liposome clearance and involvement of non-Kupffer cells in liposome uptake by mouse liver. Biochem Biophys Acta 1996; 1284: 153-161.
22. Kawabata K, Takakura Y, Hashida M. The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake. Pharm Res 1995; 12: 825-830.
23. Seymour LW et al. N-(2-hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose receptor: pharmacokinetics in DBA2 mice. Br J Cancer 1991; 63: 859-866.
24. Kooistra T, Duursma AM, Bouma JMW, Gruber M. Endocytosis and breakdown of ribonuclease oligomers by sinusoidal rat liver cells in vivo. Biochim Biophys Acta 1979; 587: 282-298.
25. Emancipator K, Elin RJ, Fleisher TA. Comparison of two automated nephelometers. J Clin Lab Anal 1992; 6: 399-404.
26. Merril CR. Gel staining techniques. Meths Enzymol 1990; 182: 477-488.