Preliminary characterization of novel amino acid based polymeric vesicles as gene and drug delivery agents

Bioconjugate Chemistry

Volumn 11, Issue 6, 2000, Pages 880-891

  Brown, M D ^a,b   Schatzlein, A ^b   Brownlie, A ^a   Jack, V ^a   Wang, W ^c   Tetley, L ^b   Gray, A I ^a   Uchegbu, I F ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CHEMICAL AND PHYSICAL PROPERTIES; CHLOROQUINE; COVALENT BOND; DOXORUBICIN; DRUG DELIVERY SYSTEM; ELECTRON MICROSCOPY; ENCAPSULATION; GENE TRANSFER; IN VITRO CULTURE; METHOXYPOLYETHYLENE GLYCOL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PALMITOYLATION; POLYMER; TRINITROBENZENESULFONIC ACID; TUMOR CELL LINE;

CELL CULTURE; CONTROLLED DRUG DELIVERY; DNA; ENCAPSULATION; ETHYLENE; ETHYLENE GLYCOL; GENE EXPRESSION; GENE TRANSFER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TARGETED DRUG DELIVERY;

AMINO-ACIDS; AMPHIPHILIC POLYMERS; AMPHIPHILICS; COVALENT ATTACHMENT; DNA COMPLEX; IN-VITRO; NON-VIRAL GENE DELIVERY; PARENT POLYMERS; POLY-L-LYSINE; POLYMERIC VESICLES;

AMINO ACIDS;

EID: 0033652541     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc000052d     Document Type: Article

References (54)

1. Introduction
2. Engineering liposomes for drug delivery: Progress and problems
3. Nonionic surfactant vesicles (niosomes) in drug delivery
4. Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis
5. Polymeric chitosan-based vesicles for drug delivery
6. Cationic liposome-mediated gene transfer
7. Gene therapy - Promises, problems and prospects
8. Viral vector systems for gene therapy
9. Lipidic vector systems for gene transfer
10. Efficient gene-transfer into mammalian primary endocrine-cells with lipopolyamine-coated DNA
11. Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block copolymers
12. Polycation-DNA complexes for gene delivery: A comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids
13. Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly(ethylene glycol)-phospholipid conjugates for efficient in vivo gene delivery
14. Evidence for the role of proteoglycans in cation-mediated gene transfer
15. Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer
16. Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery
17. Polylysine-based transfection systems utilizing receptor-mediated delivery
18. Factors controlling the efficiency of cationic lipid mediated transfection in vivo via intravenous administration
19. Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly(ethylene glycol)-phospholipid conjugates for efficient in vivo gene delivery
20. Liposomes for sustained drug release in vivo
21. A branched monomethoxypoly(ethylene glycol) for protein modification
22. An improved 2,4,6-trinitrobenzenesulfonic acid method for the determination of amines
23. Use of ethidium bromide for spearation and determination of nucleic acids of various conformational forms and measurement of their associated enzymes
24. Transfection of folate-polylysine DNA complexes: Evidence for lysosomal delivery
25. Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis
26. Glycosylated polylysine DNA complexes: Gene-transfer efficiency in relation with the size and the sugar substitution level of glycosylated polylysines and with the plasmid size
27. Efficient gene transfer by histidylated polylysine/pDNA complexes
28. Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells
29. The encapsulation of bleomycin within chitosan based polymeric vesicles does not alter its biodistribution
30. Increased liver uptake of liposomes and improved targeting efficacy by labeling with asialofetuin in rodents
31. The reduction of the positive charges of polylysine by partial gluconoylation increases the transfection efficiency of polylysine/DNA complexes
32. Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes
33. Liposomes for the sustained drug release in vivo
34. Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery
35. Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers
36. Poly(ethylene glycol)-block-poly(L-lysine) dendrimer: Novel linear polymer/dendrimer block coplymer forming a spherical water-soluble polyionic complex with DNA
37. Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery
38. Interbilayer transfer of phospholipid-anchored macromolecules via monomer diffusion
39. Insertion of poly(ethylene glycol) derivatized phospholipid into preformed liposomes results in prolonged in vivo circulation time
40. Lipophilic polylysines mediate efficient DNA transfection in mammalian-cells
41. A new nonviral DNA delivery vector: The terplex system
42. Nomenclature for synthetic gene delivery systems
43. DNA transfection mediated by cationic liposomes containing lipopolylysine: Characterization and mechanism of action
44. Structural and fusogenic properties of cationic liposomes in the presence of plasmid DNA
45. Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery
46. Influence of cholesterol on the association of plasma proteins with liposomes
47. Interaction of positively charged liposomes with blood: Implications for their application in vivo
48. Physicochemical properties and in vitro toxicity of cationic liposome cDNA complexes
49. Improved DNA: Liposome complexes for increased systemic delivery and gene expression
50. Nonviral gene therapy: The promise of genes as pharmaceutical products
51. Liposome-cell interactions in vitro: Effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomes