The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes

Gene Therapy

Volumn 4, Issue 8, 1997, Pages 823-832

  Tang, M X ^a   Szoka, F C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Compaction; DNA; Gene delivery; Polyamidoamine dendrimer; Polyethylenimine; Toroid

Indexed keywords

DENDRIMER; DNA; POLYETHYLENEIMINE; POLYLYSINE; POLYMER;

ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; DNA BINDING; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; ELECTRON MICROSCOPY; IONIC STRENGTH; LIGHT SCATTERING; PRIORITY JOURNAL; STOICHIOMETRY;

EID: 0030775528     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300454     Document Type: Article

References (41)

1. Wu GY, Wu CH. Evidence for targeted gene delivery to Hep G2 hepatoma cells in vitro. Biochemistry 1988; 27: 887-892.
2. Gottschalk S, Cristiano RJ, Smith LC, Woo SL. Folate receptor mediated DNA delivery into tumor cells: potosomal disruption results in enhanced gene expression. Gene Therapy 1994; 1: 185-191.
3. Plank C et al. The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J Biol Chem 1994; 17: 12918-12924.
4. Haensler J, Szoka FC Jr. Functionalization of polyamidoamine cascade polymers and their use for efficient transfection of cells in culture. Bioconj Chem 1993; 4: 372-379.
5. Wu GY et al. Incorporation of adenovirus into a ligand-based DNA carrier system results in retention of original receptor specificity and enhances targeted gene expression. J Biol Chem 1994; 269: 11542-11546.
6. Ferkol T, Kaetzel CS, Davis PB. Gene transfer into respiratory epithelial cells by targeting the polymeric immunoglobulin receptor. J Clin Invest 1993; 92: 2394-2400.
7. Michael SI, Curiel DT. Strategies to achieve targeted gene delivery via the receptor-mediated endocytosis pathway. Gene Therapy 1994; 1: 223-232.
8. Findeis MA, Wu CH, Wu GY. Ligand-based carrier systems for delivery of DNA to hepatocytes. Meth Enzymol 1994; 247: 341-351.
9. Boussif O et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995; 92: 7297-7301.
10. Tang MX, Redemann CT, Szoka FC Jr. In vitro gene delivery by degraded polyamidoamine dendrimers. Breconj Chem 1996; 7: 703-714.
11. Eickbush TH, Moudrianakis EN. A mechanism for the entrapment of DNA at an air-water interface. Biophys J 1977; 18: 275-288.
12. Zama M, Ichimura S. The study of the DNA structure in DNA-polylysine and DNA-polyarginine complexes: induced optical activities of bound dyes. Biochim Biophys Acta 1973; 294: 214-226.
13. Hiemenz PC. Principles of Colloid and Surface Chemistry, 2nd edn. Marcel Dekker: New York, 1986.
14. McGhee JD, von Hippel PH. Theoretical aspects of DNA-protein interactions: cooperative and non-cooperative binding of large ligands to a one-dimensional homogeneous lattice. J Mol Biol 1974; 86: 469-489.
15. Record MT Jr, Lohman TM, de Haseth P. Ion effects on ligand- nucleic acid interactions. J Mol Biol 1976; 107: 145-158.
16. Bloomfield VA. DNA condensation. Curr Opin Struct Biol 1996; 6: 334-341.
17. Tanford C. Physical Chemistry of Macromolecules. Wiley: New York, 1961.
18. Suh J, Paik H-J, Hwang BK. Ionization of poly(ethyleneimine) and poly(allylamine) at various pHs. Bioorg Chem 1994; 22: 318-327.
19. Stone AL, Epstein P. The aggregation of basic polypeptide residues bound to heparin. Biochim Biophys Acta 1977; 497: 298-306.
20. Arscott PG, Li A, Bloomfield VA. Condensation of DNA by trivalent cations. 1. Effects of DNA length and topology on the size and shape of condensed particles. Biopolymers 1990; 30: 619-630.
21. Plum GE, Arscott PG, Bloomfield VA. Condensation of DNA by trivalent cations. 2 Effects of cation structure. Biopolymers 1990; 30: 631-643.
22. Garcia-Ramirez M, Subirana JA. Condensation of DNA by basic proteins does not depend on protein composition. Biopolymers 1990; 34: 285-292.
23. Haynes M, Garrett RA, Gratzer WB. Structure of nucleic acid-poly base complexes. Biochemistry 1970; 9: 4410-4416.
24. Bram S, Beeman WW. On the cross-section structure of deoxyribonucleic acid in solution. J Mol Biol 1971; 55: 311-324.
25. Wagner E, Gotten M, Foisner R, Birnstiel ML. Transferrin-polycation DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells. Proc Natl Acad Sci USA 1991; 88: 4255-4259.
26. Wolfert MA et al. Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers. Hum Gene Ther 1996; 7: 2123-2133.
27. Wolfert MA, Seymour LW. Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of polyelectrolyte complexes formed with DNA. Gene Therapy 1996; 3: 269-273.
28. Kabanov VA et al. Complex of DNA with oppositely charged ionic surfactants: solution behaviour in water and low polarity organic solvents. Abstracts 8th International Symposium on Recent Advances in Drug Delivery, Salt Lake City, 21-24 February 1997, p 250.
29. Hud NV et al. Identification of the elemental packing unit of DNA in mammalian sperm cells by atomic force microscopy. Biochem Biophys Res Commun 1993; 193: 1347-1354.
30. Braunlin WH, Strick TJ, Record MT Jr. Equilibrium dialysis studies of polyamine binding to DNA. Biopolymers 1982; 21: 1301-1314.
31. Latt SA, Sober HA. Protein-nucleic acid interactions. II. Oligopeptide-polyribonucleotide binding studies. Biochemistry 1967; 6: 3293-3306
32. Olins DE, Olins AL, Von Hippet PH. Model nucleoprotein complexes: studies on the interaction of cationic homopolypeptides with DNA. J Mol Biol 1967; 24: 157-176.
33. Bratby J. Coagulation and Flocculation. Uplands Press: London, 1980.
34. Gregory J. Rate of flocculation of latex particles by cationic polymers. J Coll Int Sci 1973; 42: 448-456.
35. Tsuboi M, Matsuo K. Interactions of poly-L-lysine with nucleic acids. J Mol Biol 1967; 15: 256-267.
36. Moore S, Stein WH. Photometric ninhydrin method for use in the chromatography of amino acids. J Biol Chem 1948; 176: 367-388.
37. DeWet JR et al. Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol 1987; 7: 725-737.
38. McGregor GR, Caskey CT. Construction of plasmids that express E. coli β-galactosidase in mammalian cell lines. Biotechniques 1978; 7: 1116-1122.
39. Baguley BC, Denny WA, Atwell GJ, Cain BF. Potential antitumor agents. 34 Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the aniline ring. J Med Chem 1981; 24: 170-177.
40. Lohman TM, Overman LB. Two binding modes in Escherichia coli single strand binding protein-single stranded DNA complexes. J Biol Chem 1985; 260: 3594-3603.
41. Halfman CJ, Nishida T. Method for measuring the binding of small molecules to proteins from binding-induced alterations of physical-chemical properties. Biochemistry 1972; 11: 3493-3498