Controllable delivery of non-viral DNA from porous scaffolds

Journal of Controlled Release

Volumn 86, Issue 1, 2003, Pages 157-168

  Jang, Jae Hyung ^a   Shea, Lonnie D ^a  

^a Northwestern University   (United States)

Author keywords

Microspheres; Non viral DNA; Poly (lactide co glycolide); Tissue engineering

Indexed keywords

COPOLYMER; MICROSPHERE; POLYGLACTIN; RECOMBINANT DNA; RESOMER; DNA; POLYMER;

ARTICLE; CONTROLLED DRUG RELEASE; DNA INTEGRATION; DRUG DELIVERY SYSTEM; EMULSION; GENE TRANSFER; LEACHING; MOLECULAR WEIGHT; NONVIRAL GENE DELIVERY SYSTEM; PARTICULATE MATTER; POROSITY; PRESSURE; PRIORITY JOURNAL; STEM CELL; SUSTAINED RELEASE PREPARATION; TISSUE ENGINEERING; DRUG EFFECT; METHODOLOGY;

DNA; DRUG DELIVERY SYSTEMS; MICROSPHERES; POLYMERS; POROSITY;

EID: 0037426720     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00369-3     Document Type: Article

References (48)

1. Murphy W.L., Mooney D.J. Controlled delivery of inductive proteins, plasmid DNA and cells from tissue engineering matrices. J. Periodontal Res. 34:(7):1999;413-419.
2. Richardson T.P., Peters M.C., Ennett A.B., Mooney D.J. Polymeric system for dual growth factor delivery. Nat. Biotechnol. 19:(11):2001;1029-1034.
3. Blesch A., Lu P., Tuszynski M.H. Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair. Brain Res. Bull. 57:(6):2002;833-838.
4. Bottaro D.P., Liebmann-Vinson A., Heidaran M.A. Molecular signaling in bioengineered tissue microenvironments. Ann. N.Y. Acad. Sci. 961:2002;143-153.
5. Gittens S.A., Uludag H. Growth factor delivery for bone tissue engineering. J. Drug Target. 9:(6):2001;407-429.
6. Bonadio J., Goldstein S.A., Levy R.J. Gene therapy for tissue repair and regeneration. Adv. Drug Del. Rev. 33:1998;53-69.
7. Langer R. Drug delivery and targeting. Nature. 392:(6679 Suppl.):1998;5-10.
8. T. Segura, L.D. Shea, In: S. Stupp (ed.), Materials for Non-Viral Gene Delivery, Ann. Rev. Mater. Sci., 2001, pp. 25-36.
9. Fang J., Zhu Y.Y., Smiley E., Bonadio J., Rouleau J.P., Goldstein S.A., McCauley L.K., Davidson B.L., Roessler B.J. Stimulation of new bone formation by direct transfer of osteogenic plasmid genes. Proc. Natl. Acad. Sci. USA. 93:(12):1996;5753-5758.
10. Bonadio J., Smiley E., Patil P., Goldstein S. Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nat. Med. 5:(7):1999;753-759.
11. Shea L.D., Smiley E., Bonadio J., Mooney D.J. DNA delivery from polymer matrices for tissue engineering. Nat. Biotechnol. 17:(6):1999;551-554.
12. Nof M., Shea L.D. Drug-releasing scaffolds fabricated from drug-loaded microspheres. J. Biomed. Mater. Res. 59:(2):2002;349-356.
13. Tseng W.C., Haselton F.R., Giorgio T.D. Mitosis enhances transgene expression of plasmid delivered by cationic liposomes. Biochim. Biophys. Acta. 1445:(1):1999;53-64.
14. Griffith L.G., Naughton G. Tissue engineering - current challenges and expanding opportunities. Science. 295:(5557):2002;1009-1014.
15. Ando S., Putnam D., Pack D.W., Langer R. PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization. J. Pharm. Sci. 88:(1):1999;126-130.
16. Murphy W.L., Dennis R.G., Kileny J.L., Mooney D.J. Salt fusion: an approach to improve pore interconnectivity within tissue engineering scaffolds. Tissue Eng. 8:(1):2002;43-52.
17. Harris L.D., Kim B.S., Mooney D.J. Open pore biodegradable matrices formed with gas foaming. J. Biomed. Mater. Res. 42:(3):1998;396-402.
18. Murphy W.L., Peters M.C., Kohn D.H., Mooney D.J. Sustained release of vascular endothelial growth factor from mineralized poly(lactide-co-glycolide) scaffolds for tissue engineering. Biomaterials. 21:(24):2000;2521-2527.
19. Whitaker M.J., Quirk R.A., Howdle S.M., Shakesheff K.M. Growth factor release from tissue engineering scaffolds. J. Pharm. Pharmacol. 53:(11):2001;1427-1437.
20. Pandit A.S., Wilson D.J., Feldman D.S. Fibrin scaffold as an effective vehicle for the delivery of acidic fibroblast growth factor (FGF-1). J. Biomater. Appl. 14:(3):2000;229-242.
21. 2. J. Controlled Release. 66:(2-3):2000;177-185.
22. Klugherz B.D., Jones P.L., Cui X., Chen W., Meneveau N.F., DeFelice S., Connolly J., Wilensky R.L., Levy R.J. Gene delivery from a DNA controlled-release stent in porcine coronary arteries. Nat. Biotechnol. 18:(11):2000;1181-1184.
23. Nam Y.S., Park T.G. Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation. J. Biomed. Mater. Res. 47:(1):1999;8-17.
24. Borden M., Attawia M., Laurencin C.T. The sintered microsphere matrix for bone tissue engineering: in vitro osteoconductivity studies. J. Biomed. Mater. Res. 61:(3):2002;421-429.
25. Hu Y., Grainger D.W., Winn S.R., Hollinger J.O. Fabrication of poly(alpha-hydroxy acid) foam scaffolds using multiple solvent systems. J. Biomed. Mater. Res. 59:(3):2002;563-572.
26. Sheridan M.H., Shea L.D., Peters M.C., Mooney D.J. Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery. J. Controlled Release. 64:(1-3):2000;91-102.
27. Mooney D.J., Baldwin D.F., Suh N.P., Vacanti J.P., Langer R. Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials. 17:(14):1996;1417-1422.
28. Sparacio D., Beckman E.J. Generation of microcellular biodegradable polymers in supercritical carbon dioxide. ACS: Polym. Preprints. 38:1997;422-423.
29. Dixon D.J., Johnston K.P. Formation of microporous polymer fibers and oriented fibrils by precipitation with a compressed fluid antisolvent. J. Appl. Polym. Sci. 50:1993;1929-1942.
30. 2 as a foaming agent. AIChE J. 41:1995;357.
31. Goel S.K., Beckman E.J. Generation of microcellular polymeric foams using supercritical carbon dioxide. 1. Effect of pressure and temperature on nucleation. Polym. Eng. Sci. 34:1994;1137.
32. 2. Cell. Polym. 12:1993;251.
33. Arora K.A., Lesser A.J., McCarthy T.J. Preparation and characterization of microcellular polystyrene foams processed in supercritical carbon dioxide. Macromolecules. 31:1998;4614.
34. Arora K.A., Lesser A.J., McCarthy T.J. Compressive behavior of microcellular polystyrene foams processed in supercritical carbon dioxide. Polym. Eng. Sci. 38:1998;2055.
35. Cooper A.I. Polymer synthesis and processing using supercritical carbon dioxide. J. Mater. Chem. 10:(2):2000;207-234.
36. Thies J., Muller B.W. Size controlled production of biodegradable microparticles with supercritical gases. Eur. J. Pharm. Biopharm. 45:1998;67-74.
37. Debenedetti P.G., Tom J.W., Yeo S.D., Lim G.B. Application of supercritical fluids for the production of sustained delivery devices. J. Controlled Release. 24:1993;27-44.
38. Bodmeier R., Wang H., Dixon D.J., Mawson S., Johnston K.P. Polymer microspheres prepared by spraying in compressed carbon dioxide. Pharm. Res. 12:(8):1995;1211-1217.
39. Yoon J.J., Park T.G. Degradation behaviors of biodegradable macroporous scaffolds prepared by gas foaming of effervescent salts. J. Biomed. Mater. Res. 55:(3):2001;401-408.
40. Holy C.E., Dang S.M., Davies J.E., Shoichet M.S. In vitro degradation of a novel poly(lactide-co-glycolide) 75/25 foam. Biomaterials. 20:(13):1999;1177-1185.
41. Bessho K., Carnes D.L., Cavin R., Ong J.L. Experimental studies on bone induction using low-molecular-weight poly(D,L-lactide-co-glycolide) as a carrier for recombinant human bone morphogenetic protein-2. J. Biomed. Mater. Res. 61:(1):2002;61-65.
42. Luo D., Woodrow-Mumford K., Belcheva N., Saltzman W.M. Controlled DNA delivery systems. Pharm. Res. 16:(8):1999;1300-1308.
43. Hsu Y.Y., Hao T., Hedley M.L. Comparison of process parameters for microencapsulation of plasmid DNA in poly(D,L-lactic-co-glycolic) acid microspheres. J. Drug Target. 7:(4):1999;313-323.
44. Cohen H., Levy R.J., Gao J., Fishbein I., Kousaev V., Sosnowski S., Slomkowski S., Golomb G. Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles. Gene Ther. 7:(22):2000;1896-1905.
45. Walter E., Moelling K., Pavlovic J., Merkle H.P. Microencapsulation of DNA using poly(D,L-lactide-co-glycolide): stability issues and release characteristics. J. Controlled Release. 61:(3):1999;361-374.
46. Schwendeman S.P. Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems. Crit. Rev. Ther. Drug Carrier Syst. 19:(1):2002;73-98.
47. Zhu G., Mallery S.R., Schwendeman S.P. Stabilization of proteins encapsulated in injectable poly(lactide-co-glycolide). Nat. Biotechnol. 18:(1):2000;52-57.
48. Capan Y., Woo B.H., Gebrekidan S., Ahmed S., DeLuca P.P. Influence of formulation parameters on the characteristics of poly(D,L-lactide-co-glycolide) microspheres containing poly(L-lysine) complexed plasmid DNA. J. Controlled Release. 60:(2-3):1999;279-286.