PEG grafted polylysine with fusogenic peptide for gene delivery: High transfection efficiency with low cytotoxicity

Journal of Controlled Release

Volumn 79, Issue 1-3, 2002, Pages 283-291

  Lee, Haeshin ^a   Jeong, Ji Hoon ^a   Park, Tae Gwan ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Fusogenic peptide; KALA; Poly(ethylene glycol); Polylysine; Transfection

Indexed keywords

NANOPARTICLE; PEPTIDE; PEPTIDE KALA; POLYETHYLENE GLYCOL POLYLYSINE DNA COMPLEX; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; DNA TRANSFECTION; DRUG COATING; DRUG FORMULATION; DRUG SYNTHESIS; GENE DELIVERY SYSTEM; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN AGGREGATION; SURFACE CHARGE;

CELL LINE; CHEMISTRY, PHARMACEUTICAL; DNA-BINDING PROTEINS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; GENE THERAPY; PEPTIDES; POLYETHYLENE GLYCOLS; POLYLYSINE; SOLVENTS; TRANSFECTION;

EID: 0037133097     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00002-0     Document Type: Article

References (29)

1. Synthetic DNA delivery system
2. Nomenclature for synthetic gene delivery systems
3. Non-viral approaches to gene therapy
4. Polylysine-based transfection systems utilizing receptor-mediated delivery
5. In vitro gene expression in smooth muscle cells using a terplex system
6. Characterization of a targeted gene carrier, lactose-polyethylene glycol-grafted poly-L-lysine, and its complex with plasmid DNA
7. Lactose-poly(ethylene glycol)-grafted poly-L-lysine as hepatoma cell-targeted gene carrier
8. Polyethylene glycol-grafted poly-L-lysine as polymeric gene carrier
9. Water soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(L-lysine) block copolymers
10. Remarkable increase in nuclease resistance of plasmid DNA through supra-molecular assembly with poly(ethylene glycol)-poly(L-lysine) block copolymer
11. Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferring-polylysine-DNA complexes: Toward a synthetic virus-like gene-transfer vehicle
12. Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA
13. Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers
14. The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems
15. Effect of membrane-active agents in gene delivery
16. Application of membrane-active peptides for non-viral gene delivery
17. Binding of cationic a-helical peptides to plasmid DNA and their gene transfer abilities into cells
18. Protamine sulfate enhanced lipid-mediated gene transfer
19. Chloroquine and amphipathic peptide helices show synergistic transfection in vitro
20. Rhinovirus mediated endosomal release of transfection complexes
21. A novel DNA-peptide complex for efficient gene transfer and expression in mammalian cells
22. The influence of membrane-active peptides and helper lipids on lipospermine/DNA complex mediate gene transfer
23. Polycation-DNA complexes for gene delivery: A comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids
24. Poly(DMAEMA-NVP)-b-PEG-galactose as gene delivery vector for hepatocytes
25. Use of PEG conjugated fusogenic peptide for enhancing transfection efficiency of polyethylenimine/DNA complexes
26. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
27. Poly(amidoamine)s with potential as drug carriers: Degradation and cellular toxicity
28. DNA transfection using linear poly(ethylenimine) prepared by controlled acid hydrolysis of poly(2-ethyl-2-oxazoline)