Role of endogenous endonucleases and tissue site in transfection and CpG-mediated immune activation after naked DNA injection

Human Gene Therapy

Volumn 10, Issue 15, 1999, Pages 2461-2480

  Barry, Mary E ^a,b   Pinto González, Dasein ^b   Orson, Frank M ^b   McKenzie, Gregory J ^b   Petry, George R ^a   Barry, Michael A ^a,b,c  

^a CENTER FOR CELL AND GENE THERAPY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c The NanoCarbon Center and Welch Institute for Advanced Materials   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE;

ANIMAL CELL; ARTICLE; DNA DEGRADATION; ENDOSOME; ENZYME ACTIVE SITE; ENZYME ACTIVITY; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION; GENE INSERTION; GENETIC TRANSFECTION; HOST CELL; IMMUNE RESPONSE; MOUSE; NONHUMAN; REPORTER GENE;

ANIMALS; BASE SEQUENCE; CALCIUM; CELL LINE; CPG ISLANDS; DNA; DNA PRIMERS; ENDONUCLEASES; FEMALE; IMMUNITY, CELLULAR; INTERFERON TYPE II; MICE; MICE, INBRED BALB C; MUSCLES; SKIN; SPLEEN; TRANSFECTION;

ANIMALIA;

EID: 2442761730     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950016816     Document Type: Article

References (53)

1. ACSADI, G., JIAO, S., JANI, A., DUKE, D., WILLIAMS, P., CHONG, W., and WOLFF, J.A. (1991). Direct gene transfer and expression into rat heart in vivo. New Biol. 3, 71-81.
2. ANDERSSON, S., DAVIS, D.N., DAHLBACK, H., JÖRNVALL, H., and RUSSELL, D.W. (1989). Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J. Biol. Chem. 264, 8222-8229.
3. ARONICA, E.M., GORTER, J.A., GROOMS, S., KESSLER, J.A., BENNETT, M.V., ZUKIN, R.S., and ROSENBAUM, D.M. (1998). Aurintricarboxylic acid prevents GLUR2 mRNA down-regulation and delayed neurodegeneration in hippocampal CA1 neurons of gerbil after global ischemia. Proc. Natl. Acad. Sci. U.S.A. 95, 7115-7120.
4. BAKER, K.P., BARON, W.F., HENZEL, W.J., and SPENCER, S.A. (1998). Molecular cloning and characterization of human and murine DNase II. Gene 215, 281-289.
5. BALLAS, K.K., RASMUSSEN, W.L., and KRIEG, A.M. (1996). Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157, 1840-1845.
6. BARRY, M.A., and EASTMAN, A. (1993). Identification of deoxyribonuclease II as an endonuclease involved in apoptosis. Arch. Biochem. Biophys. 300, 440-450.
7. BARRY, M.A., and JOHNSTON, S.A. (1996). Biological features of genetic immunization. Vaccine 15, 788-791.
8. BASSEL-DUBY, R., HERNANDEZ, M.D., GONZALEZ, M.A., KRUEGER, J.K., and WILLIAMS, R.S. (1992). A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter. Mol. Cell. Biol. 12, 5024-5032.
9. BERNARDI, G., and GRIFFE, M. (1964). Studies on acid deoxyribonuclease. II. Isolation and characterization of spleen-acid deoxyribonuclease. Biochemistry 3, 1419-1426.
10. CHACE, J.H., HOOKER, N.A., MILDENSTEIN, K.L., KRIEG, A.M., and COWDERY, J.S. (1997). Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12. Clin. Immunol. Immunopathol. 84, 185-193.
11. COEN, D.M. (1992). Quantitation of rare DNAs by PCR. In Short Protocols in Molecular Biology. (John Wiley & Sons, New York) pp. 15-10-15-12.
12. COONROD, A., LI, F.Q., and HORWITZ, M. (1997). On the mechanism of DNA transfection: Efficient gene transfer without viruses. Gene Ther. 4, 1313-1321.
13. COTTEN, M., LÄNGLE-ROUAULT, F., KIRLAPPOS, H., WAGNER, E., MECHTLER, K., ZENKE, M., BEUG, H., and BIRNSTIEL, M.L. (1990). Transferrin-polycation-mediated introduction of DNA into human leukemic cells: Stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptors. Proc. Natl. Acad. Sci. U.S.A. 87, 4033-4037.
14. CURIEL, D.T., AGARWAL, S., WAGNER, E., and COTTEN, M. (1991). Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proc. Natl. Acad. Sci. U.S.A. 88, 8850-8854.
15. FELTQUATE, D.M., HEANEY, S., WEBSTER, R.G., and ROBINSON, H.L. (1997). Different T cell types and antibody isotypes generated by saline and gene gun DNA immunization. J. Immunol. 58, 2278-2284.
16. FYNAN, E.F., WEBSTER, R.G., FULLER, D.H., HAYNES, J.R., SANTORO, J.C., and ROBINSON, H.L. (1993). DNA vaccines: Protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc. Natl. Acad. Sci. U.S.A. 90, 11478-11482.
17. GIACONA, M.B., RUBEN, G.C., ICZKOWSKI, K.A., ROOS, T.B., PORTER, D.M., and SORENSON, G.D. (1998). Cell-free DNA in human blood plasma: Length measurements in patients with pancreatic cancer and healthy controls. Pancreas 17, 89-97.
18. GILBERT, M., BRIGIDO, L., MULLER, W.E., HANSEN, J.E., EZEKOWITZ, R.A., and MILLS, J. (1993). Screening for inhibitors of HIV gp120-CD4 binding using an enzyme-linked immunoabsorbent assay. J. Virol. Methods 42, 1-12.
19. HARLOW, E., and LANE, D. (1988). Immunizations. In Antibodies: A Laboratory Manual (Cold Spring Harbor Laboratories, Cold Spring Harbor, NY) pp. 108-109.
20. HOKE, G.D., DRAPER, K., FREIER, S.M., GONZALEZ, C., DRIVER, V.B., ZOUNES, M.C., and ECKER, D.J. (1991). Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection. Nucleic Acids Res. 19, 5743-5748.
21. JOHNSTON, S.A., RIEDY, M., DEVIT, M.J., SANFORD, J.C., MCELLIGOTT, S., and WILLIAMS, R.S. (1991). Biolistic transformation of animal tissue. In Vitro Cell. Dev. Biol. 27P, 11-14.
22. KLINMAN, D.M., YI, A.K., BEAUCAGE, S.L., CONOVER, J., and KRIEG, A.M. (1996). CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc. Natl. Acad. Sci. U.S.A. 93, 2879-2883.
23. KRIEG, A.M., YI, A.K., MATSON, S., WALDSCHMIDT, T.J., BISHOP, G.A., TEASDALE, R., KORETZKY, G.A., and KLINMAN, D.M. (1995). CpG motifs in bacterial DNA trigger direct B-cell activation. Nature (London) 374, 546-549.
24. KRIEG, A.M., MATSON, S., and FISHER, E. (1996). Oligodeoxynucleotide modifications determine the magnitude of B cell stimulation by CpG motifs. Antisense Nucleic Acid Drug Dev. 6, 133-139.
25. KRIESER, R.J., and EASTMAN, A. (1998). The cloning and expression of human deoxyribonuclease II: A possible role in apoptosis. J. Biol. Chem. 273, 30909-30914.
26. LECHARDEUR, D.E.A. (1999). Metabolic instability of plasmid DNA in the cytosol: A potential barrier to gene transfer. Gene Ther. 6, 482-497.
27. LECLERC, C., DERIAUD, E., ROJAS, M., and WHALEN, R.G. (1997). The preferential induction of a Th1 immune response by DNA-based immunization is mediated by the immunostimulatory effect of plasmid DNA. Cell. Immunol. 179, 97-106.
28. LEVY, M.Y., BARRON, L.G., MEYER, K.B., and SZOKA, F.C., JR. (1996). Characterization of plasmid DNA transfer into mouse skeletal muscle: Evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Ther. 3, 201-211.
29. LEW, D.E.A. (1995). Cancer gene therapy using plasmid DNA: Pharmacokinetic study of DNA following injection in mice. Hum. Gene Ther. 6, 553-564.
30. MAIER, M., BLEICHER, K., KALTHOFF, H., and BAYER, E. (1995). Enzymatic degradation of various antisense oligonucleotides: Monitoring and fragment identification by MECC and ES-MS. Biomed. Peptides Proteins Nucleic Acids 1, 235-242.
31. MANTHORPE, M., CORNEFERT-JENSEN, F., HARTIKKA, J., FELGNER, J., RUNDELL, A., MARGALITH, M., and DWARKI, V. (1993). Gene therapy by intramuscular injection of plasmid DNA: Studies on firefly luciferase gene expression in mice. Hum. Gene Ther. 4, 419-431.
32. MESSINA, J.P., GILKESON, G.S., and PISETSKY, D.S. (1991). Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J. Immunol. 147, 1759-1764.
33. PAN, C.Q., and LAZARUS, R. A. (1997). Engineering hyperactive variants of human deoxyribonuclease I by altering its functional mechanism. Biochemistry 36, 6624-6632.
34. PEITSCH, M.C., IRMLER, M., FRENCH, L.E., and TSCHOPP, J. (1995). Genomic organisation and expression of mouse deoxyribonuclease I. Biochem. Biophys. Res. Commun. 207, 62-68.
35. RAZ, E., CARSON, D.A., PARKER, S.E., PARR, T.B., ABAI, A.M., AICHINGER, G., GROMKOWSKI, S.H., SINGH, M., LEW, D., YANKAUCKAS, M.A., BAIRD, S.M., and RHODES, G.H. (1994). Intradermal gene immunization: The possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. Natl. Acad. Sci. U.S.A. 91, 9519-9523.
36. ROMAN, M., MARTIN-OROZCO, E., GOODMAN, J.S., NGUYEN, M.D., SATO, Y., RONAGHY, A., KORNBLUTH, R.S., RICHMAN, D.D., CARSON, D.A., and RAZ, E. (1997). Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nature Med. 3, 849-854.
37. ROSS, G.F., BRUNO, M.D., UYEDA, M., SUZUKI, K., NAGAO, K., WHITSETT, J.A., and KORFHAGEN, T.R. (1998). Enhanced reporter gene expression in cells transfected in the presence of DMI-2, an acid nuclease inhibitor. Gene Ther. 5, 1244-1250.
38. 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate. Mol. Pharmacol. 45, 932-943.
39. SATO, Y., ROMAN, M., TIGHE, H., LEE, D., CORR, M., NGUYEN, M.D., SILVERMAN, G.J., LOTZ, M., CARSON, D.A., and RAZ, E. (1996). Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273, 352-354.
40. STRAUSS, W.M. (1992). Preparation of genomic DNA from mammalian tissue. In Short Protocols in Molecular Biology (John Wiley & Sons, New York) pp. 2-8-2-9.
41. TAKESHITA, H., YASUDA, T., NAKAJIMA, T., HOSOMI, O., NAKASHIMA, Y., and KISHI, K. (1997). Mouse deoxyribonuclease I (DNase I): Biochemical and immunological characterization. cDNA structure and tissue distribution. Biochem. Mol. Biol. Int. 42, 65-75.
42. TIDD, D.M., and WARENIUS, H.M. (1989). Partial protection of oncogene, anti-sense oligodeoxyribonucleotides against serum nuclease degradation using terminal methylphosphate groups. Br. J. Cancer 60, 343-350.
43. WAGNER, E., ZATLOUKAL, K., COTTEN, M., KIRLAPPOS, H., MECHTLER, K., CURIEL, D.T., and BIRNSTIEL, M.L. (1992). Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proc. Natl. Acad. Sci. U.S.A. 89, 6099-6103.
44. WANG, Y., XIANG, Z., PASQUINI, S., and ERTL, H.C. (1997). Immune response to neonatal genetic immunization. Virology 228, 278-284.
45. WILLIAMS, R.S., JOHNSTON, S.A., RIEDY, M., DEVIT, M.J, MCELLIGOTT, S.G., and SANFORD, J.C. (1991). Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. Proc. Natl. Acad. Sci. U.S.A. 88, 2726-2730.
46. WINKELMANN, R.K., ZOLLMAN, P.E., and BALDES, E.J. (1963). Squamous cell carcinoma produced by ultraviolet light in hairless mice. J. Invest. Dermatol. 40, 217-224.
47. WOLFF, J.A., MALONE, R.W., WILLIAMS, P., CHONG, W., ACSADI, G., JANI, A., and FELGNER, P.L. (1990). Direct gene transfer into mouse muscle in vivo. Science 247, 1465-1468.
48. WOLFF, J.A., LUDTKE, J.J., ACSADI, G., WILLIAMS, P., and JANI, A. (1992). Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum. Mol. Genet. 1, 363-369.
49. YAMANAKA, M.E.A. (1974). Purification and properties of acid deoxyribonucleases of human gastric mucosa and cervix uteri. J. Biol. Chem. 249, 3884-3889.
50. YASUDA, T., TAKESHITA, H., IIDA, R., NAKAJIMA, T., HOSOMI, O., NAKASHIMA, Y., and KISHI, K. (1998). Molecular cloning of the cDNA encoding human deoxyribonuclease II. J. Biol. Chem. 273, 2610-2616.
51. YI, A.K., TUETKEN, R., REDFORD, T., WALDSCHMIDT, M., KIRSCH, J., and KRIEG, A.M. (1998). CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J. Immunol. 160, 4755-4761.
52. ZHAO, Q., MATSON, S., HERRERA, C.J., FISHER, E., YU, H., and KRIEG, A.M. (1993). Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphosphonate oligonucleotides. Antisense Res. Dev. 3, 53-66.
53. ZHAO, Q., SONG, X., WALDSCHMIDT, T., FISHER, E., and KRIEG, A.M. (1996). Oligonucleotide uptake in human hematopoietic cells is increased in leukemia and is related to cellular activation. Blood 88, 1788-1795.