Prospects for cationic polymers in gene and oligonucleotide therapy against cancer

Advanced Drug Delivery Reviews

Volumn 54, Issue 5, 2002, Pages 715-758

  Merdan, Thomas ^a,b   Kopeček, Jindrich ^b   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Cationic polymers; Gene therapy; Non viral gene delivery; Polyethylenimine; Subcellular trafficking; Targeting

Indexed keywords

GENES; MEDICAL IMAGING; POLYMERS; TISSUE; TOXICITY;

OLIGONUCLEOTIDE THERAPY;

DRUG DOSAGE;

1,2 DIMYRISTYLOXYPROPYL 3 DIMETHYLHYDROXYETHYLAMMONIUM BROMIDE; 3BETA [N (N',N' DIMETHYLAMINOETHANE)CARBAMOYL]CHOLESTEROL; ANTIBODY CONJUGATE; ANTISENSE OLIGONUCLEOTIDE; CANCER VACCINE; CELLFECTIN; CGP 69846A; CHITOSAN DERIVATIVE; DENDRIMER; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; EXGEN 500; FOLIC ACID; FOMIVIRSEN; GENE EXPRESSION MODULATOR 231; GTI 2040; IMIDAZOLE DERIVATIVE; ISIS 2503; ISIS 3521; LIPOFECTAMINE; LIPOFECTIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MACROGOL; OBLIMERSEN; P53 TUMOR SUPPRESSOR PROTEIN POLYETHYLENEIMINE CONJUGATE; PLASMID DNA; PLASMID DNA POLYETHYLENEIMINE CONJUGATE; POLYETHYLENEIMINE; POLYFECT; POLYLYSINE; POLYLYSINE DNA COMPLEX; POLYMER; STARBURST; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BIODEGRADABILITY; BYSTANDER EFFECT; CANCER; CELL TYPE; CLINICAL TRIAL; COMPLEX FORMATION; COVALENT BOND; DRUG SAFETY; ENDOSOME; GENE EXPRESSION; GENE REPLACEMENT THERAPY; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; IMMUNOGENICITY; IONIZATION; LUNG METASTASIS; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEAR PORE COMPLEX; PRIORITY JOURNAL; REVIEW; VACCINATION;

ANIMALS; CATIONS; CLINICAL TRIALS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GENE EXPRESSION; GENE THERAPY; HUMANS; NEOPLASMS; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; POLYMERS; RNA, CATALYTIC; TISSUE DISTRIBUTION;

EID: 0037072576     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(02)00046-7     Document Type: Review

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