Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery

Angewandte Chemie - International Edition

Volumn 42, Issue 27, 2003, Pages 3153-3158

  Anderson, Daniel G ^a   Lynn, David M ^b   Langer, Robert ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

DNA; Gene therapy; High throughput screening; Polycations; Polymers

Indexed keywords

FLUORESCENCE; GENES; POLYMERS; PROTEINS;

TRANSFECTION POTENTIAL;

SYNTHESIS (CHEMICAL);

DNA; GREEN FLUORESCENT PROTEIN; LUCIFERASE; POLYCATION; POLYETHYLENEIMINE; POLYMER;

ANIMAL CELL; ARTICLE; AUTOMATION; CONTROLLED STUDY; DEGRADATION; DRUG SCREENING; DRUG SYNTHESIS; FIBROBLAST; GENE THERAPY; GENETIC TRANSFECTION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PLASMID VECTOR;

ANIMALS; AUTOMATION; CATIONS; CERCOPITHECIDAE; COS CELLS; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; GENE THERAPY; MOLECULAR STRUCTURE; POLYMERS; TRANSFECTION;

EID: 0042311016     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200351244     Document Type: Article

References (18)

1. http://www.wiley.co.uk/genetherapy/clinical/2002.
2. N. Somia, I. M. Verma, Nat. Rev. Genet. 2000, 1, 91.
3. F. D. Ledley, Hum. Gene Ther. 1995, 6, 1129.
4. D. Luo, W. M. Saltzman, Nat. Biotechnol. 2000, 18, 33.
5. J. Fominaya, W. Wels, J. Biol. Chem. 1996, 271, 10560.
6. J. J. Schwartz, S. Zhang, Curr. Opin. Mol. Ther. 2000, 2, 162.
7. O. Boussif, F. Lezoualch, M. A. Zanta, M. D. Mergny, D. Scherman, B. Demeneix, J. P. Behr, Proc. Natl. Acad. Sci. USA 1995, 92, 7297.
8. A. V. Kabanov, P. L. Felgner, L. W. Seymour, Self-assembling complexes for gene delivery: from laboratory to clinical trial, Wiley, Chichester, New York, 1998.
9. Y. B. Lim, C. H. Kim, K. Kim, S. W. Kim, J. S. Park, J. Am. Chem. Soc. 2000, 122, 6524.
10. Y. B. Lim, S. M. Kim, H. Suh, J. S. Park, Bioconjugate Chem. 2002, 13, 952.
11. D. M. Lynn, R. Langer, J. Am. Chem. Soc. 2000, 122, 10761.
12. D. M. Lynn, D. G. Anderson, D. Putnam, R. Langer, J. Am. Chem. Soc. 2001, 123, 8155.
13. S. Brocchini, Adv. Drug Delivery Rev. 2001, 53, 123.
14. J. E. Murphy, T. Uno, J. D. Hamer, F. E. Cohen, V. Dwarki, R. N. Zuckermann, Proc. Natl. Acad. Sci. USA 1998, 95, 1517.
15. S. Brocchini, K. James, V. Tangpasuthadol, J. Kohn, J. Am. Chem. Soc. 1997, 119, 4553.
16. C. L. Gebhart, A. V. Kabanov, J. Controlled Release 2001, 73, 401.
17. J. S. Remy, B. Abdallah, M. A. Zanta, O. Boussif, J. P. Behr, B. Demeneix, Adv. Drug Delivery Rev. 1998, 30, 85.
18. D. V. Schaffer, N. A. Fidelman, N. Dan, D. A. Lauffenburger, Biotechnol. Bioeng. 2000, 67, 598.