Size-dependency of nanoparticle-mediated gene transfection: Studies with fractionated nanoparticles

International Journal of Pharmaceutics

Volumn 244, Issue 1-2, 2002, Pages 105-115

  Prabha, Swayam ^a   Zhou, Wen Zhong ^a   Panyam, Jayanth ^a   Labhasetwar, Vinod ^a,b  

^a 986025 University of Nebraska Medical Center ^*  (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Biodegradable polymers; Cellular uptake; Gene therapy; Non viral vectors

Indexed keywords

DNA; LUCIFERASE; NANOPARTICLE; POLYGLACTIN; POLYLACTIC ACID;

ANIMAL CELL; ARTICLE; BIOCOMPATIBILITY; BIODEGRADATION; CELL STRAIN COS7; CONTROLLED STUDY; DRUG FORMULATION; EVAPORATION; FRACTIONATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MEMBRANE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL;

BIOCOMPATIBLE MATERIALS; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; ELECTROPHORESIS, AGAR GEL; GENE THERAPY; LACTIC ACID; PARTICLE SIZE; PLASMIDS; POLYGLYCOLIC ACID; POLYMERS; TECHNOLOGY, PHARMACEUTICAL; TRANSFECTION;

EID: 0037026269     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00315-0     Document Type: Article

References (38)

1. Ando S., Putnam D., Pack D.W., Langer R. PLGA microspheres containing plasmid DNA: Preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization. J. Pharm. Sci. 88:1999;126-130.
2. Bergan D., Galbraith T., Sloane D.L. Gene transfer in vitro and in vivo by cationic lipids is not significantly affected by levels of supercoiling of a reporter plasmid. Pharm. Res. 17:2000;967-973.
3. Bonadio J., Smiley E., Patil P., Goldstein S. Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nat. Med. 5:1999;753-759.
4. Cherng J.Y., Schuurmans-Nieuwenbroek N.M., Jiskoot W., Talsma H., Zuidam N.J., Hennink W.E., Crommelin D.J. Effect of DNA topology on the transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid complexes. J. Control. Release. 60:1999;343-353.
5. Clark K.R., Johnson P.R. Gene delivery of vaccines for infectious disease. Curr. Opin. Mol. Ther. 3:2001;375-384.
6. Cohen H., Levy R.J., Gao J., Fishbein I., Kousaev V., Sosnowski S., Slomkowski S., Golomb G. Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles. Gene Ther. 7:2000;1896-1905.
7. Dauty E., Remy J.S., Blessing T., Behr J.P. Dimerizable cationic detergents with a low cmc condense plasmid DNA into nanometric particles and transfect cells in culture. J. Am. Chem. Soc. 123:2001;9227-9234.
8. Davda J., Labhasetwar V. Characterization of nanoparticle uptake by endothelial cells. Int. J. Pharm. 233:2002;51-59.
9. Desai M.P., Labhasetwar V., Walter E., Levy R.J., Amidon G.L. The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm. Res. 14:1997;1568-1573.
10. Escriou V., Carriere M., Bussone F., Wils P., Scherman D. Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer. J. Gene Med. 3:2001;179-187.
11. Harvie P., Wong F.M., Bally M.B. Use of poly(ethylene glycol)-lipid conjugates to regulate the surface attributes and transfection activity of lipid-DNA particles. J. Pharm. Sci. 89:2000;652-663.
12. Hedley M.L., Curley J., Urban R. Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses. Nat. Med. 4:1998;365-368.
13. Joshi D.P., Lan-Chun-Fung Y.L., pritchard J.G. Determination of poly vinyl alcohol via its complex with boric acid and iodine. Anal. Chim. Acta. 104:1979;153-160.
14. Kataoka K., Harashima H. Gene delivery systems: viral vs. non-viral vectors. Adv. Drug Deliv. Rev. 52:2001;151.
15. Klugherz B.D., Jones P.L., Cui X., Chen W., Meneveau N.F., DeFelice S., Connolly J., Wilensky R.L., Levy R.J. Gene delivery from a DNA controlled-release stent in porcine coronary arteries. Nat. Biotechnol. 18:2000;1181-1184.
16. Kochanek S., Schiedner G., Volpers C. High-capacity 'gutless' adenoviral vectors. Curr. Opin. Mol. Ther. 3:2001;454-463.
17. Kreiss P., Cameron B., Rangara R., Mailhe P., Aguerre-Charriol O., Airiau M., Scherman D., Crouzet J., Pitard B. Plasmid DNA size does not affect the physicochemical properties of lipoplexes but modulates gene transfer efficiency. Nucleic Acids Res. 27:1999;3792-3798.
18. Labhasetwar V., Bonadio J., Goldstein S., Levy R.J. Gene transfection using biodegradable nanospheres: results in tissue culture and a rat osteotomy model. Colloids Surfaces B: Biointerfaces. 16:1999;281-290.
19. Lee H., Williams S.K., Allison S.D., Anchordoquy T.J. Analysis of self-assembled cationic lipid-DNA gene carrier complexes using flow field-flow fractionation and light scattering. Anal. Chem. 73:2001;837-843.
20. Li S., Huang L. Nonviral gene therapy: promises and challenges. Gene Ther. 7:2000;31-34.
21. Luo D., Woodrow-Mumford K., Belcheva N., Saltzman W.M. Controlled DNA delivery systems. Pharm. Res. 16:1999;1300-1308.
22. Maheshwari A., Mahato R.I., McGregor J., Han S., Samlowski W.E., Park J.S., Kim S.W. Soluble biodegradable polymer-based cytokine gene delivery for cancer treatment. Mol. Ther. 2:2000;121-130.
23. Mao H.Q., Roy K., Troung-Le V.L., Janes K.A., Lin K.Y., Wang Y., August J.T., Leong K.W. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J. Control. Release. 70:2001;399-421.
24. Müller R.H. Colloidal Carriers for Controlled Drug Delivery and Targeting. 1991;CRC press, Boca Raton.
25. Ohno T., Gordon D., San H., Pompili V.J., Imperiale M.J., Nabel G.J., Nabel E.G. Gene therapy for vascular smooth muscle cell proliferation after arterial injury. Science. 265:1994;781-784.
26. Panyam, J., Lof, J., O'Leary, E., Labhasetwar, V., 2002a. Efficiency of Dispatch® and Infiltrator® cardiac infusion catheters in arterial localization of nanoparticles in a porcine coronary model of restenosis. J. Drug Target, in press.
27. Panyam, J., Zhou, W.Z., Prabha, S., Sahoo, S.K., Labhasetwar, V., 2002b. Rapid endolysosomal escape of poly (D,L-lactide-co-glycolide) nanoparticles: Implications for drug and gene delivery. FASEB J., in press.
28. Perez C., Sanchez A., Putnam D., Ting D., Langer R., Alonso M.J. Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA. J. Control. Release. 75:2001;211-224.
29. Richardson T.P., Peters M.C., Ennett A.B., Mooney D.J. Polymeric system for dual growth factor delivery. Nat. Biotechnol. 19:2001;1029-1034.
30. Roy K., Mao H.Q., Huang S.K., Leong K.W. Oral gene delivery with chitosan - DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat. Med. 5:1999;387-391.
31. Rubanyi G.M. The future of human gene therapy. Mol. Aspects Med. 22:2001;113-142.
32. Sahoo, S.K., Panyam, J., Prabha, S., Labhasetwar, V., 2002. Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. J. Control, Release 82, 105-114.
33. Sakurai F., Inoue R., Nishino Y., Okuda A., Matsumoto O., Taga T., Yamashita F., Takakura Y., Hashida M. Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression. J. Control. Release. 66:2000;255-269.
34. Truong-Le V.L., August J.T., Leong K.W. Controlled gene delivery by DNA-gelatin nanospheres. Hum. Gene Ther. 9:1998;1709-1717.
35. Walter E., Moelling K., Pavlovic J., Merkle H.P. Microencapsulation of DNA using poly(DL-lactide-co-glycolide): stability issues and release characteristics. J. Control. Release. 61:1999;361-374.
36. Wang D., Robinson D.R., Kwon G.S., Samuel J. Encapsulation of plasmid DNA in biodegradable poly(D,L-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery. J. Control. Release. 57:1999;9-18.
37. Zambaux M.F., Bonneaux F., Gref R., Maincent P., Dellacherie E., Alonso M.J., Labrude P., Vigneron C. Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method. J. Control. Release. 50:1998;31-40.
38. Zauner W., Farrow N.A., Haines A.M. In vitro uptake of polystyrene microspheres: effect of particle size, cell line and cell density. J. Control. Release. 71:2001;39-51.