Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery

Journal of the American Chemical Society

Volumn 125, Issue 18, 2003, Pages 5316-5323

  Akinc, Akin ^a   Lynn, David M ^b   Anderson, Daniel G ^a   Langer, Robert ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b University of Wisconsin Madison   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; DEGRADATION; GENE TRANSFER; MONOMERS; PH EFFECTS; POLYESTERS;

SURFACE CHARGE;

SYNTHESIS (CHEMICAL);

ACRYLIC ACID DERIVATIVE; DNA; MONOMER; NAKED DNA; POLY(BETA AMINO ESTER) DERIVATIVE; POLYMER; UNCLASSIFIED DRUG;

ACIDITY; ADDITION REACTION; ANIMAL CELL; ARTICLE; BIOPHYSICS; COMPLEX FORMATION; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; DEGRADATION; DNA DETERMINATION; GENE DELIVERY SYSTEM; GENE LIBRARY; GENE TRANSFER; LYSOSOME; MATERIALS; MEASUREMENT; MOLECULAR PHYSICS; NONHUMAN; PH; POLYMERIZATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TRANSPORT KINETICS; ZETA POTENTIAL;

3T3 CELLS; ANIMALS; DNA; ELECTROSTATICS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HYDROGEN-ION CONCENTRATION; MICE; PARTICLE SIZE; POLYAMINES; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES; TRANSFECTION;

EID: 0038293017     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja034429c     Document Type: Article

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