Pharmaceutical and biological properties of poly(amino acid)/DNA polyplexes

Journal of Drug Targeting

Volumn 7, Issue 2, 1999, Pages 143-156

  Lucas, P ^a   Milroy, D A ^a   Thomas, B J ^a   Moss, S H ^a   Pouton, C W ^a  

^a University of Bath   (United Kingdom)

Author keywords

DNA condensation; Gene delivery; Polycation; Polylysine; Transfection

Indexed keywords

ARGININE; ELECTROLYTE; LYSINE; ORNITHINE; POLYARGININE; POLYCATION; POLYLYSINE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; GENE TARGETING; GENE TRANSFER; GENETIC TRANSFECTION; MELANOMA CELL; MOLECULAR WEIGHT; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; POLYMERIZATION; PRIORITY JOURNAL; ZETA POTENTIAL;

EID: 0032727028     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869909085498     Document Type: Article

References (44)

1. Alton, E.W., Middleton, P.G., Caplen, N.J., Smith. S.N., Steel, D.M., Munkonge, F.M., Jeffery, P.K., Geddes, D.M., Hart, S.L., Williamson, R., Fasold, K.I., Miller, A.D., Dickinson, P., Stevenson, B.J., Maclachlan, G., Dorin, J.R. and Porteous, D.J. (1993). Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice. Nat. Genet., 5, 135-142.
2. Behr, J.P., Dorin, J.R., Demeinex, B., Loeffler, J.P. and Perez-Mutul, J. (1989). Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coatcd DNA. Proc. Natl. Acad. Sci. USA, 86, 6982-6986.
3. Bloomfield, V.A. (1996). DNA condensation. Curr. Opinion Struct. Biol., 6, 334-341.
4. Bond, C.V. and Wold, B. (1987). Poly-L-ornithine-mediated transformation of mammalian cells. Mol. Cell. Biol., 7, 2286-2293.
5. Boussif, O., Lezoualch, F., Zanta, M.A., Mergny, M.D., Scherman, D., Demeneix, B. and Behr, J.-P. (1995). A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethyleneimine. Proc. Natl. Acad. Sci. USA, 92, 7297-7301.
6. Caplan, N.J., Alton, E.W., Middleton, P.G., Dorin, J.R., Stevenson, B.J., Gao, X., Durham, S.R., Jeffery, P.K., Hodson, M.E., Coutelle, C., Huang, L., Porteous, D.J., Williamson, R. and Geddes, D.M. (1995). Liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nat. Med., 1, 39-46.
7. Carroll, D. (1972a). Optical properties of deoxyribonucleic acid polylysine complexes. Biochemistry, 11. 421-426.
8. Carroll, D. (1972b). Complexes of polylsyine with polyuridylic acid and other polynucleotides. Biochemistry, 11, 426-433.
9. Cheng, P.-W. (1996). Receptor ligand-facililated gene transfer: enhancement of liposome-mediated gene transfer and expression by transferrin. Hum. Gene Ther., 7, 275-282.
10. Cotten, M., Laengle-Rouault, F., Kirlappos, H., Wagner, E., Michtler, K., Zenke, M., Beug, H. and Birnstiel, M.L. (1990). Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. Proc. Natl. Acad. Sci. USA, 87, 4033-4037.
11. Felgner, P.L., Barenholtz, Y., Behr, J.-P., Cheng, S.H., Cullis, P., Huang, L., Jessee, J.A., Seymour, L., Szoka, F., Thierry, A.R., Wagner, E. and Wu, G. (1997). Nomenclature for synthetic gene delivery systems. Hum. Gene Ther., 8, 511-512.
12. Gao, X. and Huang, L. (1996). Potentiation of cationic liposome-mediated gene delivery by polycations. Biochemistry, 35, 1027-1036.
13. Gershon, H., Ghirlando, R., Guttman, S.B. and Minsky, A. (1993). Mode of formation and structural features of DNA cationic liposome complexes used for transfection. Biochemistry, 32, 7143-7151.
14. Gill, D.R., Southern, K.W. Mofford, K.A. Seddon, T., Huang, L., Sorgi, F., Thomson, A., Macvinish, L.J., Ratcliff, R., Bilton, D., Lane, D.J., Littlewood, J.M., Webb, A.K., Middleton, P.G., Colledge, W.H., Cuthbert, A.W., Evans, M.J., Higgins, C.F. and Hyde, S.C. (1997). A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis. Gene Ther., 4, 199-209.
15. Gottschalk, S., Sparrow, J.T., Hauer, J., Mims, M.P., Leland, F.E., Woo, S.L.C. and Smith, L.C. (1996). A novel DNA/peptide complex for efficient gene transfer and expression in mammalian cells. Gene Ther., 3, 448-457.
16. Haensler, J. and Szoka. F.C. (1993). Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug. Chem., 4, 372-379.
17. Hofland, H.E.J., Shephard, L. and Sullivan, S.M. (1996). Formulation of stable cationic lipid/DNA complexes for gene transfer. Proc. Natl. Acad. Sci. USA, 93, 7305-7309.
18. Hud, N.V., Downing, K.H. and Balhorn, R. (1995). A constant radius of curvature model for the organization of DNA in toroidal condensates. Proc. Natl. Acad. Sci. USA, 92, 3581-3585.
19. Kabanov, A.V. and Kabanov, V.A. (1995). DNA complexes with polycations for the delivery of genetic material into cells. Bioconj. Chem., 6, 7-20.
20. Kukowska-Latallo, J.F., Bielinska, A.U., Johnson, J., Spindler, R., Tomalia, D.A. and Baker, J.R. (1996). Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers. Proc. Natl. Acad. Sci. USA, 93, 4897-4902.
21. Ledley, F.D. (1995). Nonviral gene therapy: the promise of genes as pharmaceutical products. Hum. Gene Ther., 6, 1129-1144.
22. Liu, F., Qi, H., Huang, L. and Liu, D. (1997). Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration. Gene Ther., 4, 517-523.
23. MacGregor, G.R., Nolan, G.P., Fiering, S., Roederer, M. and Herzenberg, L.A. (1991) Use of E. culi lacZ (β-galactosidase) as a reporter gene. Methods Mol. Biol. 7, 217-235.
24. Monsigny, M., Roche, A.C., Midoux, P. and Mayer, R. (1994). Glycoconjugates as carriers for specific delivery of therapeutic drugs and genes. Adv. Drug Del. Rev., 14, 1-24.
25. Plank, C. Oberhauser, B., Mechtler, K., Koch, C. and Wagner, E. (1994). The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J. Biol. Chem., 269, 12919-12924.
26. Plank, C., Mechtler, K., Szoka, F.C. and Wagner, E. (1996). Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum. Gen Ther., 7, 1437-1446.
27. Pouton, C.W., Lucas, P., Thomas, B.J., Uduchi, A.N., Milroy, D.A. and Moss, S.H (1998) Polycation DNA complexes for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids. J. Controlled Rel., 53, 289-299.
28. Pouton, C.W. (1998). Nuclear uptake of macromoleeules and supramolecular complexes. Adv. Drug Delivery Rev., 34, 51-64.
29. Reimer, D.L., Zhang, Y., Kong, S., Wheeler, J.J., Graham, R.W. and Bally, M.B. (1995). Formation of novel hydrophobic complexes between cationic lipids and plasmid DNA. Biochemistry, 34, 12877-12883.
30. Szala, S., Missol, E., Sochanik, A. and Strozyk, M. (1996). The use of cationic liposomes DC-CHOL/DOPE and DDAB/ DOPE for direct transfer of Escherschia coli cytosine deanminase gene into growing melanoma tumors. Gene Ther., 3, 1026-1031.
31. Tomlinson, E. and Rolland, A. (1996). Controllable gene therapy: pharmaceutics of non-viral gene delivery systems. J. Control. Rel., 39, 357-372.
32. Wagner, E., Zenke, M., Cotten, M., Beug, H. and Birnstiel, M.L. (1990). Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proc. Natl. Acad. Sci. USA, 87, 3410-3414.
33. Wagner, E., Zatloukal, K., Cotten, M., Kirlappos, H., Mechtler, K., Curiel, D.T. and Birnstiel, M.E. (1992a) Coupling of adenovirus to transferrin polylysine. DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proc. Natl. Acad. Sci. USA, 89, 6099-6103.
34. Wagner, E., Plank, C., Zatloukal, K., Cotten, M. and Birnstiel, M.L. (1992b). Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine/DNA complexes: towards a synthetic virus-like gene transfer vehicle. Proc. Natl. Acad. Sci. USA, 89, 7934-7938.
35. Wilke, M., Fortunati, E., Van Den Brock, M., Hoogeveen, A.T. and Scholte, B.J. (1996). Efficacy of a peptide-based gene delivery system depends on mitotic activity. Gene Ther., 3, 1133-1142.
36. Wolfert, M.A. and Seymour, L.W. (1996a). Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of polyelectrolyte complexes formed with DNA. Gene Ther., 3, 269-273.
37. Wolfert, M.A., Schacht, E.H., Toncheva, V., Ulbrich, K., Nazarova, O. and Seymour, L.W. (1996b). Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers. Hum. Gene Ther., 7, 2123-2133.
38. Wu, G.Y. and Wu, C. H. (1987). Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. J. Biol. Chem., 262, 4429-4432.
39. Wyman, T.B., Nicol, F., Zelphati, O., Scaria, P.V., Plank, C. and Szoka, F.C. (1997). Design, synthesis and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers. Biochemistry, 36, 3008-3017.
40. Xu, L., Pirollo, K.F. and Chang, E.H. (1997). Transferrin-liposome-mediated p53 sensitization of squamous cell carcinoma of the head and neck to radiation in vitro. Hum. Gene Ther., 8, 467-475.
41. Xu, Y. and Szoka, F.C. (1996). Mechanism of DNA release from cationic liposome DNA complexes used in cell transaction. Biochemistry, 35, 5616-5623.
42. Yang, J.-P. and Huang, L. (1996). Direct gene transfer to mouse melanoma by intratumor injection of free DNA. Gene Ther., 3, 542-548.
43. Yew, N.S., Wysokenski, D.M., Wang, K.X., Ziegler, R.J.. Marshall, J., McNeilly, D., Cherry, M., Osburn, W. and Cheng, S.H. (1997). Optimization of plasmid vactors for high-level expression in lung epithelial cells. Hum. Gene Ther., 8, 575-584.
44. Zabner, J., Fasbender, A.L., Moninger, T., Poellinger, K.A. and Welsh, M.J. (1995). Cellular and molecular barriers to gene transfer by a cationic lipid. J. Biol. Chem., 270, 18947-19007.