Controlled release of plasmid DNA from a genetically engineered silk-elastinlike hydrogel

Pharmaceutical Research

Volumn 19, Issue 7, 2002, Pages 954-959

  Megeed, Z ^a   Cappello, J ^b   Ghandehari, H ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b Protein Polymer Technologies Inc   (United States)

Author keywords

Controlled release; Gene delivery; Genetically engineered polymers; Hydrogels; Silk elastinlike polymers

Indexed keywords

PLASMID DNA; POLYMER; BACTERIAL PROTEIN; BIOPOLYMER; ELASTIN; FIBROIN; FIBRONECTIN; HYBRID PROTEIN; SILK LIKE PROTEIN POLYMER; SILK-LIKE PROTEIN POLYMER;

ARTICLE; CALCULATION; CHEMICAL COMPOSITION; CONTROLLED DRUG RELEASE; DRUG DIFFUSION; DRUG RELEASE; GENE DELIVERY SYSTEM; GENETIC ENGINEERING; HYDROGEL; ION EXCHANGE; IONIC STRENGTH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RECOMBINANT DNA TECHNOLOGY; AMINO ACID SEQUENCE; DELAYED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; GENETICS; METHODOLOGY; MOLECULAR GENETICS; PLASMID; SILK;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; ELASTIN; GENETIC ENGINEERING; HYDROGELS; MOLECULAR SEQUENCE DATA; PLASMIDS; POLYMERS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; BIOPOLYMERS; FIBROINS; FIBRONECTINS; RECOMBINANT FUSION PROTEINS; SILK;

EID: 0035997328     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016406120288     Document Type: Article

References (20)

1. Degradable poly(β-amino esters): Synthesis, characterization, and self-assembly with plasmid DNA
2. A cationic lipid emulsion/DNA complex as a physically stable and serum-resistant gene delivery system
3. Comparitive gene transfer efficiency of low molecular weight polylysine DNA-condensing peptides
4. Controlled DNA delivery systems
5. DNA delivery from polymer matrices for tissue engineering
6. Controlled release of plasmid DNA
7. Formulation and in vitro transfection efficiency of poly (d,l-lactide-co-glycolide) microspheres containing plasmid DNA for gene delivery
8. Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle
9. Interaction of processes on different length scales in a bioelastomer capable of performing free energy conversion
10. Design and biosynthesis of elastin-like artificial extracellular matrix proteins containing periodically spaced fibronectin cs5 domains
11. In-situ self-assembling protein polymer gel systems for administration, delivery, and release of drugs
12. Genetically engineered protein polymers
13. Reversible hydrogels from self-assembling artificial proteins
14. A unified mathematical model for diffusion from drug-polymer composite tablets
15. Calculation of the dimensions of drug-polymer devices based on diffusion parameters
16. Solution behavior and self-assembly of complexes from poly(α-methylstyrene)-block-poly(n-ethyl-4-vinyl-pyridinium) cations and aerosol OT anions
17. Effect of electrostatic interactions on polylysine release rates from collagen matrices and comparison with model predictions
18. Swelling characteristics of silk-elastinlike hydrogels
19. Diffusion in polyelectrolyte hydrogels: Application of an obstruction-scaling model to solute diffusion in calcium alginate