Gene delivery of vaccines for infectious disease

Current Opinion in Molecular Therapeutics

Volumn 3, Issue 4, 2001, Pages 375-384

  Clark, K R ^a   Johnson, P R ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

DNA vaccines; Genetic immunization; Infectious disease; Vaccine; Viral vectors

Indexed keywords

CYTOKINE; DNA VACCINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; OLIGONUCLEOTIDE; PLASMID DNA; POLYPEPTIDE; RNA; TUMOR NECROSIS FACTOR ALPHA; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ADENOVIRUS; ALPHA VIRUS; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DNA VECTOR; DRUG DELIVERY SYSTEM; DRUG SAFETY; ELECTROPORATION; EXPERIMENTAL ANIMAL; GENE EXPRESSION; GENE REPLICATION; GENE SILENCING; GENE TARGETING; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IN VIVO STUDY; INFECTION; MOUSE; NONHUMAN; PLANT; POXVIRUS; PROTEIN DOMAIN; RAT; SKIN; SUICIDE GENE; TARGET CELL;

ADENOVIRIDAE; ANIMALS; DENDRITIC CELLS; DEPENDOVIRUS; ELECTROPORATION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; INFECTION CONTROL; VACCINATION; VACCINES, DNA;

EID: 0034879346     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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2. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
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6. Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells
7. Encapsulation of plasmid DNA in biodegradable poly(D,L-lactic-coglycolic acid) microspheres as a novel approach for immunogene delivery
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10. Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization
11. Gene transfer into muscle by electroporation in vivo
12. Muscle transfection by electroporation with high-voltage and short-pulse currents provides high-level and long-lasting gene expression
13. Electropermeabilization of skeletal muscle enhances gene transfer in vivo
14. Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: Superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells
15. Long-term production of erythropoietin after electroporation-mediated transfer of plasmid DNA into the muscles of normal and uremic rats
16. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo
17. Enhancing B- and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer
18. Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice
19. Generating and regulating immune responses through cutaneous gene delivery
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24. Immunization via hair follicles by topical application of naked DNA to normal skin
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39. Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles
40. Recombinant RNA replicons derived from attenuated Venezuelan equine encephalitis virus protect guinea pigs and mice from Ebola hemorrhagic fever virus
41. A striking property of recombinant poxviruses: Efficient inducers of in vivo expansion of primed CD8(+) T-cells
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54. Evaluation of a recombinant Listeria monocytogenes expressing an HIV protein that protects mice against viral challenge
55. Unique immunogenicity of hepatitis B virus DNA vaccine presented by live-attenuated Salmonella typhimurium
56. Protective efficacy against tuberculosis of ESAT-6 secreted by a live Salmonella typhimurium vaccine carrier strain and expressed by naked DNA
57. Mucosal immunization with Salmonella typhimurium expressing Lassa virus nucleocapsid protein cross-protects mice from lethal challenge with lymphocytic choriomeningitis virus
58. Sindbis virus-induced silencing of dengue viruses in mosquitoes
59. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
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