PEGylated DNA/transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

Gene Therapy

Volumn 6, Issue 4, 1999, Pages 595-605

  Ogris, M ^a   Brunner, S ^a   Schuller S ^a   Kircheis, R ^b   Wagner, E ^a,b  

^a UNIVERSITY OF VIENNA   (Austria)

^b BOEHRINGER INGELHEIM RCV GMBH AND CO KG   (Austria)

Author keywords

Erythrocyte interaction; In vivo gene transfer; Plasma interaction; Polyethylene glycol; Polyethylenimine

Indexed keywords

COMPLEMENT COMPONENT C3; FIBRINOGEN; FIBRONECTIN; IMMUNOGLOBULIN M; LIPOSOME; MACROGOL; PLASMA PROTEIN; POLYETHYLENE; POLYETHYLENEIMINE; TRANSFERRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ERYTHROCYTE AGGREGATION; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; MOUSE; NONHUMAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PROTEIN BINDING; REPORTER GENE; SURFACE CHARGE; TOXICITY; TUMOR;

ANIMALS; BIOPHYSICS; BLOOD PROTEINS; CELL LINE; DNA; ERYTHROCYTES; FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; LUCIFERASES; MICE; MICE, INBRED STRAINS; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; TRANSFECTION;

ANIMALIA;

EID: 0032938324     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300900     Document Type: Article

References (49)

1. Chonn A, Semple SC, Cullis PR. Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes. J Biol Chem 1992; 267: 18759-18765.
2. Senior J et al. Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles. Biochim Biophys Acta 1991; 1062: 77-82.
3. Mori A, Klibanov AL, Torchilin VP, Huang L. Influence of the steric barrier activity of amphipathic poly(ethyleneglycol) and ganglioside GM1 on the circulation time of liposomes and on the target binding of immunoliposomes in vivo. FEBS Lett 1991; 284: 263-266.
4. Torchilin VP et al. Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo. Biochim Biophys Acta 1994; 1195: 181-184.
5. Woodle MC, Engbers CM, Zalipsky S. New amphipatic polymer-lipid conjugates forming long-circulating reticuloendothelial system-evading liposomes. Bioconjug Chem 1994; 5: 493-496.
6. Boussif O et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995; 92: 7297-7301.
7. Abdallah B et al. A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Hum Gene Ther 1996; 7: 1947-1954.
8. Ferrari S et al. ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo. Gene Therapy 1997; 4: 1100-1106.
9. Kircheis R et al. Coupling of cell-binding ligands to polyethylenimine for targeted gene transfer. Gene Therapy 1997; 4: 409-418.
10. Zanta MA, Boussif O, Adib A, Behr JP. In vitro gene delivery to hepatocytes with galactosylated polyethylenimine. Bioconjug Chem 1997; 8: 839-844.
11. Dunlap DD, Maggi A, Soria MR, Monaco L. Nanoscopic structure of DNA condensed for gene delivery. Nucleic Acids Res 1997; 25: 3095-3101.
12. Goula D et al. Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system. Gene Therapy 1998; 5: 712-717.
13. Ogris M et al. The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Therapy 1998; 5: 1425-1433.
14. Wolfert MA et al. Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers. Hum Gene Ther 1996; 7: 2123-2133.
15. Cotten M et al. Adenovirus polylysine DNA conjugates. In: Dracopoli NC et al (eds). Current Protocols in Human Genetics. John Wiley and Sons: New York, 1996, pp 12.3.1-12.3.33.
16. Needham D, McIntosh TJ, Lasic DD. Repulsive interactions and mechanical stability of polymer-grafted lipid membranes. Biochim Biophys Acta 1992; 1108: 40-48.
17. Plank C, Mechtler K, Szoka FJ, Wagner E. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum Gene Ther 1996; 7: 1437-1446.
18. Wagner E, Curiel D, Cotten M. Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis. Adv Drug Del Rev 1994; 14: 113-136.
19. Allen TM, Hansen C. Pharmacokinetics of stealth versus conventional liposomes: effect of dose. Biochim Biophys Acta 1991; 1068: 133-141.
20. Papahadjopoulos D. Fate of liposomes in vivo: a brief introductory review. J Liposome Res 1996; 6: 3-17.
21. Absolom DR. Opsonins and dysopsonins: an overview. Meth Enzymol 1986; 132: 281-318.
22. Park YS, Huang L. Effect of chemically modified GM1 and neo-glycolipid analogs of GM1 on liposome circulation time: evidence supporting the dysopsonin hypothesis. Biochim Biophys Acta 1993; 1166: 105-114.
23. Semple SC, Chonn A, Cullis PR. Influence of cholesterol on the association of plasma proteins with liposomes. Biochemistry 1996; 35: 2521-2525.
24. Semple SC, Chonn A. liposome blood protein interactions in relation to liposome clearence. J Liposome Res 1996; 6: 32-60.
25. Moghimi SM et al. Coating particles with a block co-polymer (poloxamine-908) suppresses opsonization but permits the activity of dysopsonins in the serum. Biochim Biophys Acta 1993; 1179: 157-165.
26. Litzinger DC, Huang L. Amphipathic poly(ethylene glycol) 5000-stabilized dioleoylphosphatidylethanolamine liposomes accumulate in spleen. Biochim Biophys Acta 1992; 1127: 249-254.
27. Torchilin VP et al. Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium. FASEB J 1992; 6: 2716-2719.
28. Blume G et al. Specific targeting with poly(ethylene glycol)-modified liposomes: coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times. Biochim Biophys Acta 1993; 1149: 180-184.
29. Maruyama K et al. Immunoliposomes bearing polyethyleneglycol-coupled Fab′ fragment show prolonged circulation time and high extravasation into targeted solid tumors in vivo. FEBS Lett 1997; 413: 177-180.
30. Gerlowski LE, Jain RK. Microvascular permeability of normal and neoplastic tissues. Microvasc Res 1986; 31: 288-305.
31. Unezaki S et al. Direct measurement of the extravasation of polyethyleneglycol-coated liposomes into solid tumor tissue by in vivo fluorescence microscopy, Int J Pharmaceutics 1996; 144: 11-17.
32. Sadzuka Y, Hirotsu S, Hirota S. Effect of liposomalization on the antitumor activity, side-effects and tissue distribution of CPT-11. Cancer Lett 1998; 127: 99-106.
33. Schwartz B et al. Lipospermine based gene transfer into the newborn mouse brain is optimized by a low lipospermine/DNA charge ratio. Hum Gene Ther 1995; 6: 1515-1524.
34. Li S, Rizzo MA, Bhattacharya S, Huang L. Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery. Gene Therapy 1998; 5: 930-937.
35. Tang MX, Szoka FC. The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Therapy 1997; 4: 823-832.
36. McLean JW et al. Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice. Am J Physiology Heart Circ Physiol 1997; 42: H387-H404.
37. Liu Y et al. Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery. Nat Biotechnol 1997; 15: 167-173.
38. Li S, Huang L. In vivo gene transfer via intravenous administration of cationic lipid protamine DNA (LPD) complexes. Gene Therapy 1997; 4: 891-900.
39. Templeton NS et al. Improved DNA: liposome complexes for increased systemic delivery and gene expression. Nat Biotechnol 1997; 15: 647-652.
40. Litzinger DC et al. Fate of cationic liposome and their complex with oligonucleotide in vivo. Biochim Biophys Acta 1996; 1281: 139-149.
41. Liu F, Qi H, Huang L, Liu D. Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration. Gene Therapy 1997; 4: 517-523.
42. Goula D et al. Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Therapy 1998; 5: 1291-1295.
43. Plank C et al. The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J Biol Chem 1994; 269: 12918-12924.
44. Zauner W, Ogris M, Wagner E. Polylysine-based transfection systems utilizing receptor-mediated delivery. Adv Drug Delivery Rev 1998; 30: 97-113.
45. Sebestyen MG et al. DNA vector chemistry: the covalent attachment of signal peptides to plasmid DNA. Nat Biotechnol 1998; 16: 80-85.
46. Plank C et al. Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand. Bioconjug Chem 1992; 3: 533-539.
47. Bloom H, Beier H, Gross HS. Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels. Electrophoresis 1987; 8: 93-99.
48. Miller J, Schätzel B, Vincent J. The determination of very small electrophoretic mobilities in polar and nonpolar colloidal dispersions using phase analasys light scattering. J Coll Intersci 1991; 143: 532-555.
49. Kircheis R et al. Polycation-based DNA complexes for tumor-targeted gene delivery in vivo. J Gene Med 1999 (in press).